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Identification and Structural Analysis of New Nrf2 Activators by Mechanism‐Based Chemical Transformation of 15‐Deoxy‐Δ12, 14‐PGJ2 下载免费PDF全文
Dr. Kyeojin Kim Dr. Jong‐Min Park Prof. Nam‐Jung Kim Dr. Su‐Jung Kim Hyunyoung Moon Dr. Hongchan An Prof. Jeeyeon Lee Prof. Hyun‐Ju Park Prof. Young‐Joon Surh Prof. Young‐Ger Suh 《Chembiochem : a European journal of chemical biology》2016,17(20):1900-1904
Mechanism‐based chemical transformation of 15‐deoxy‐Δ12, 14‐PGJ2 (15d‐PGJ2) resulted in a series of new NF‐E2‐related factor‐2 (Nrf2) activators and detailed elucidation of the function of each electrophilic binding site. In addition, HO‐1 expression resulting from Nrf2 activation through enhanced dissociation of the Keap1–Nrf2 complex by the new activators was proved. 相似文献
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Ming-Yu Yen Min-Chien Hsiao Shu-Hang Liao Po-I Liu Han-Min Tsai Chen-Chi M. Ma Nen-Wen Pu Ming-Der Ger 《Carbon》2011,49(11):3597-3606
This study employed a solution-based method to prepare a 3-D hybrid material comprising graphene and acid-treated multi-walled carbon nanotubes (MWCNTs). The adsorption of MWCNTs on graphene reduces the π–π interaction between graphene sheets resulting from steric hindrance, providing a subsequent reduction in aggregation. Optimal proportions of MWCNTs to graphene (2:1) enabled the even distribution of individual MWCNTs deposited on the surface of the graphene. The hybrid 3-D material was incorporated within a TiO2 matrix and used as a working electrode in dye-sensitized solar cells (DSSCs). The hybrid material provides a number of advantages over electrodes formed of either MWCNTs or graphene alone, including a greater degree of dye adsorption and lower levels of charge recombination. In this study, DSSCs incorporating 3-D structured hybrid materials demonstrated a conversion efficiency of 6.11%, which is 31% higher than that of conventional TiO2-based devices. 相似文献
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Juan Manuel Balderas-López Witoon Prinyawiwatkul Gerónimo Arámbula-Villa Francisco Hernández-Rosas Otto Raul Leyva-Ovalle Eric Pascal Houbron José Andrés Herrera-Corredor 《International Journal of Food Science & Technology》2019,54(3):705-714
Removing solid lime particles (SLP) may help to prevent polluting characteristics of corn cooking wastewater (nejayote). The objective of this study was to evaluate the polluting characteristics of nejayote and characteristics of nixtamal, masa and tortilla using SLP-free solutions (SLPF) for the nixtamalisation process. Two SLPF treatments: calcium hydroxide (CHYDROX) and calcium oxide (COXIDE) were compared against traditional nixtamalisation (TRADNIX). Polluting characteristics including pH, settleable solids, total hardness, alkalinity and chemical oxygen demand (COD) reduced by 29.5% and 24.3%, 61.9% and 63.3%, 46.3% and 54.7%, 43.3% and 55.1%, 41.1% and 67.7% in CHYDROX and COXIDE, respectively, compared to TRADNIX. Masas and tortillas from SLPF treatments were whiter than those from TRADNIX. Moisture in SLPF tortillas was lower by 4.3–6.3% compared to TRADNIX. Tortillas from SLPF treatments had higher maximum tensile strength (0.04–0.08 N mm−2) than TRADNIX. Removing SLP is a viable strategy for preventing pollution from the nixtamalisation process. 相似文献
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M. Alpaslan E. Boydak M. Hayta S. Gerçek M. Simsek 《Journal of the American Oil Chemists' Society》2001,78(9):933-935
The effect of row space (RS) and irrigation (IR) on total protein, total oil, and fatty acid composition of Harran-grown sesame
seed was studied. Total oil content of sesame varied from 46.4 to 51.5%. The oil and protein contents were significantly different
among treatments (P<0.01) in 1998 and 1999. IR affected oil content significantly (P<0.01) in both years, and RS had no significant effect. The protein content was significantly influenced by RS and IR at P<0.05 and P<0.01, respectively. RS 70 cm had the highest protein content followed by RS 60, 50, and 40 cm, respectively. IR every 24th
day resulted in the highest level of protein, followed by 18th-, 12th-, and 6th-day irrigation, respectively. Correlation
coefficients between protein and oil content were −0.34 in 1998 and −0.59 in 1999. RS (P<0.05) and IR (P<0.01) influenced oleic and linoleic acid contents significantly. Interactions of RS and IR were also found to be significant
(P<0.05) over the oleic and linoleic acid levels. 相似文献
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This paper examines the global impacts of a policy that internalizes the external costs (related to air pollution damage, excluding climate costs) of electricity generation using a combined energy systems and macroeconomic model. Starting point are estimates of the monetary damage costs for SO2, NOX, and PM per kWh electricity generated, taking into account the fuel type, sulfur content, removal technology, generation efficiency, and population density. Internalizing these externalities implies that clean and advanced technologies increase their share in global electricity production. Particularly, advanced coal power plants, natural gas combined cycles, natural gas fuel cells, wind and biomass technologies gain significant market shares at the expense of traditional coal- and gas-fired plants. Global carbon dioxide emissions are lowered by 3% to 5%. Sulfur dioxide emissions drop significantly below the already low level. The policy increases the costs of electricity production by 0.2 (in 2050) to 1.2 € cent/kWh (in 2010). Gross domestic product losses are between 0.6% and 1.1%. They are comparatively high during the initial phase of the policy, pointing to the need for a gradual phasing of the policy. 相似文献
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Ben van Berkel Caroline Bos Astrid Piber Nuno Almeida Ger Gijzen Cynthia Markhoff Luis Etchegorry Ramon van der Heijden Marcin Koltunski Fernie Lai Patrik Noome 《城市环境设计》2010,(1):24-27
这一体育场的设计灵感来源于中国古代蹴鞠的色彩层次和叠加的构造。设计将观众的集体精神、建筑的公共领域和城市内涵交织在一起。主体育场将观众席、广播电视中心、管理区、贵宾休息室、运动员设施和公共大厅安置在一个分层次的空间中,这一空间延伸到地表层,在双层停车设施上部提供户外的公共空间。 相似文献
40.
Ben van Berkel Astrid Piber Ger Gijzen Marc Herschel Marianthi Tatari Sander Versluis Jorg Lonkwitz Tom Minderhoud Constantin Boincean Amsterdam 《城市环境设计》2010,(1):64-69
该大楼有20层,包含55个公寓,在楼中可以眺望啥德逊河、东河和曼哈顿的天际线。
该大楼有一个戏剧性、极富装饰性的立面,灵感来自Tribeca的19世纪的铸铁建筑和当代时尚。闪闪发光的黑色金属横带将包装的墙面扭曲,划分了阳台、平台和遮阳篷的位置,同时体现了立面的框架感。 相似文献