人血丙种球蛋白治疗重症手足口病48例

目的:探讨人血丙种球蛋白对重症手足口病(神经系统受累期)早期治疗的临床体会,为重症手足口病的临床治疗提供参考。方法:回顾性总结分析我院在2012年8月至2013年9月期间收治的96例重症手足口病患者的临床病例资料,随机分为治疗组和对照组各48例,两组均用利巴韦林、甲基泼尼松龙和甘露醇治疗,治疗组加人血丙种球蛋白进行治疗,比较两组患者的临床治疗效果及死亡率。结果:治疗组和对照组临床疗效及死亡率差异有显著统计学意义(P0.01)。结论:早期应用人血丙种球蛋白治疗重症手足口病疗效好,住院天数缩短,死亡率明显下降。     

Perceptual Embodiment of Prosthetic Limbs by Transcutaneous Electrical Nerve Stimulation

Objectives: In able‐bodied participants, it is possible to induce a sense of perceptual embodiment in an artificial hand using a visual‐tactile illusion. In amputee patients, electrical stimulation of sensory afferents using transcutaneous electrical nerve stimulation (TENS) has been shown to generate somatic sensations in an amputee's phantom limb(s). However, the effects of TENS on the perceptual embodiment of an artificial limb are not known. Our objective was to investigate the effects of TENS on the perceptual embodiment of an artificial limb in fully intact able‐bodied participants. Materials and Methods: We used a modified version of the rubber hand illusion presented to 30 able‐bodied participants (16 women, 14 men) to convey TENS paresthesia to an artificial hand. TENS electrodes were located over superficial radial nerve on the lateral aspect of the right forearm (1 cm proximal to the wrist), which was hidden from view. TENS intensity was increased to a strong non‐painful TENS sensation (electrical paresthesia) was felt beneath the electrodes and projecting into the fingers of the hand. The electrical characteristics of TENS were asymmetric biphasic electrical pulsed waves, continuous pulse pattern, 120 Hz pulse frequency (rate), and 80 µs pulse duration (width). Results: Participants reported significantly higher intensities of the rubber hand illusion during the two TENS conditions (mean = 5.8, standard deviation = 1.9) compared with the two non‐TENS conditions (mean = 4.9, standard deviation = 1.7), p < 0.0005. Conclusions: Our findings provide initial evidence that TENS paresthesia can be projected into an artificial limb, and this can enhance the sense of perceptual embodiment of an artificial hand. Further exploratory studies involving an amputee population are warranted.     

2011—2012年麻城市手足口病流行病学特征分析

目的：了解2011—2012年湖北省麻城市手足口病流行特征及其变化。方法：采用描述性流行病学方法对2011—2012年麻城市手足口病疫情监测资料进行统计分析。结果：2011—2012年麻城市共报告手足口病3299例。年均发病率为141．81／10万，无手足口病重症及死亡病例；全市各乡镇均有病例报告；报告病例中≤3岁儿童占85．40．4；男女性别比为1．98：1；病例主要集中在散居儿童；全年有两个发病高峰，且10—12月发病高峰明显高于4—7月发病高峰，2011年10-12月发病报告病例数占当年病例总数的71．14％，2012年占61．49％。结论：麻城市手足口病的发生存在明显的年龄、性别和季节差异，2011—2012年季节分布表现为双高峰，和流行优势病原体变化等因素有关。     

2011年成都市手足口病疫情

目的 为掌握成都市手足口病流行规律,有针对性提出防治措施建议.方法 通过国家疫情网收集2011年手足口病疫情信息,通过qRT - PCR方法实施病原体检测.结果 成都市2011年手足口病报告发病18284例,其中重症283例,死亡3例,年报告发病率125.22/10万,病死率低于全国平均水平,无暴发疫情发生.四季均发病,呈双峰流行,5岁以下儿童是主要发病人群,病原体优势毒株由EV71向CoxA16转变的趋势.结论 2011年成都市手足口病总体发病水平较高,但病死率低,无暴发疫情,早期预警和治疗可有效预防暴发和降低病死率.