国产辛伐他汀治疗原发性高胆固醇血症的临床观察

目的：比较国产及进口辛伐他汀治疗原发性高胆固醇血症的疗效及安全性。方法：选择原发性高胆固醇血症患34例，随机入选国产（试验组）和进口（对照组）辛伐他汀组。每日晚餐后服用辛伐他汀10mg共持续8周，分别观察用药前、用药后4周和8周时血清胆固醇、甘油三酯、高密度脂蛋白胆固醇水平及不良反应情况。结果：用药8周后试验组和对照组血清胆固醇水平分别下降26．23％和17．87％，甘油三酯水平分别下降16．80％和17．25％，高密度脂蛋白胆固醇水平分别升高6．64％和6．74％。两组均无明显不良反应发生。结论：国产辛伐他汀治疗原发性高胆固醇血症的疗效肯定且较安全，可作为同类进口药物的替代产品。     

舒降之治疗老年人高胆固醇血症的疗效和安全性

目的：探讨舒降之（辛伐他汀）治疗老年人高胆固醇血症的临床疗效和安全性。方法：30例老年高胆固醇血症患者连续服小剂量舒降之（5－10mg/d)8周，治疗期间在第4周和第8周监测血脂、空腹血糖、肝功能、肾功能、肌酸激酶等。结果：血脂改善总有效率总胆固醇（TC）为87％（26／30），甘油三酯（TG）及高密度脂蛋白胆固醇（HDL－C）均为53％（16／30），低密度脂蛋白胆固醇（LDL－C）为93％（28／30）。治疗前后实验室检查结果差异无显著性（P＞0．05）。结论：小剂量舒降之治疗老年高胆固醇血症有效且安全。     

茶色素治疗冠心病52例临床研究

７５例冠心病患者分为二组，一组５２例 给予口服茶色素胶囊（茶色素治疗组），另一组２３例给予口服γ－月见草胶丸（对照组），服药１月后观察到治疗组患有胸痛、胸闷、心悸、气急，头晕等症状明显缓解，有效率为９６．１５％、９４．２３％、７８．８％、７１．１５％和８６．５４％。心电图提出心肌缺血征象明显改善，总有效率为６５．３８％。对血清总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白（ＨＤＬ）、低密度脂蛋白     

茶色素治疗血脂代谢紊乱的临床观察

观察茶色素治疗血脂代谢紊乱的疗效。方法：２４６例血脂代谢紊乱病人口服茶色素胶囊一个月。结果：高甘油三脂血症者有效率５７．５％,改善幅度１７．８ｍｍｏｌ／Ｌ。高胆固醇血症者有效率３７．６％,幅度８．０ｍｍｏｌ／Ｌ。     

普罗布考治疗高胆固醇血症的近期临床疗效观察

目的：评价普罗布考片（Probucol)应用于高胆固醇血症患者的有效性和安全性。方法：80例高胆固醇血症患者入选本研究（其中33例患者同时有高甘油三酯血症）,连续服用普罗布考片4周,每天2次,每次500mg,用药后4周测定血清总胆固醇（TC）,高密度脂蛋白（HDL－C）,甘油三酯（TG）及低密度脂蛋白（LDL－C）,结果：服用普罗布考片4周后,患者TC下降25．3％（P＜0．001）,LDL－C下降30．8％（P＜0．001）,HDL－C下降13．2％（P＜0．05）。伴有高甘油三酯血症患者的TG下降7．4％（P＞0．05）,在本研究中,除有2例患者因为腹泻而退出研究,没有发现其他严重的副作用,结论：普罗布考片可以安全,有效的降低高胆固醇患者的TC,LDL－C和HDL－C。     

茶色素对高脂血症的治疗作用

观察茶色素对高脂血症的治疗作用。４５例高因症患者口服茶色素１２５ｍｇ／次，每日３次，疗程１个月，自身对照。茶色素有明显降低血脂作用；降低血清总胆固醇的有效率为６６．７％。降低甘油三脂的总有效率为６１．１％，提高高密度脂蛋白胆固醇的有效率为６０．０％，降低低密度脂蛋白脂白胆因醇的有效率为７２．２％。血液 变学变化提示茶色素具有凝，促纤溶，防止血小板粘附与聚集等多种药得作用。     

阿托伐他汀40mg治疗原发性高血压合并高胆固醇血症疗效观察

目的：观察每日服用阿托伐他汀（立普妥）40mg的降脂疗效及耐受性。方法：取110例原发性高血压合并高胆固醇血症患者,每晚服用立普妥40mg,疗程8周。结果：立普妥40mg可降低血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL—C）、分别降低30．3％、28．3％及35．1％（P均〈0．01）,降低TC的总有效率为87．2％,降低TG的总有效率为65．8％。升高高密度脂蛋白胆固醇（HDL—C）的总有效率为51％。结论：每晚服用立普妥40mg降脂疗效确切,安全性、耐受性良好。     

辛伐他汀治疗老年高脂血症的疗效和安全性

目的观察辛伐他汀治疗老年高脂血症，特别是高胆固醇血症的疗效和安全性。方法选取58名老年高脂血症患者应用辛伐他汀20mg／d治疗，每3个月检查血脂、血尿常规、肝肾功能、肌酸激酶等生化指标1次．随访至少24个月，观察其调脂疗效和不良反应。结果辛伐他汀能使总胆固醇（TC）平均下降26．30％，低密度脂蛋白胆固醇（LDL—C）平均下降28．63％，甘油三酯（TG）平均下降16．38％，高密度脂蛋白胆固醇（HDL—C）平均上升8．16％；在随访期间，未发现有明显的不良反应出现。结论辛伐他汀有明显降低TC、LDL—C的作用，对TG也有一定降低作用，HDL—C则有一定升高作用；该药长期应用具有良好的安全性。     

高甘油三酯合并低HDL血症患者PGI_2生物活性的研究

为探讨甘油三酯（TG）升高、高密度脂蛋白（HDL）降低与前列环素（PGI2）生物活性改变间的相互关系，选择65例高TG合并低HDL血症患者，以PGI2对二磷酸腺苷（ADP）诱导的血小板聚集的抑制率作为PGI2生物活性的指标，观察了其对PGI2生物活性的影响。结果发现，高TG合并低HDL血症时血小板聚集抑制率在10、20、50min时分别为（69．8±21．5）％、（47．5±25．0）％、（26．7±23．3）％，而对照组分别为（77．2±17．3）％、（60．7±26．1）％、（36．0±15．6）％，P＜0．05或＜0．01，表明高TG合并低HDL血症时对PGI2生物活性的稳定作用明显降低（P＜0．01）。提示HDL对PGI2的稳定作用是由于其延长了PGI2的半寿期，而高TG血症可能通过使HDL降低而间接地影响PGI2的生物活性。     

茶色素治疗高脂血症172例疗效观察

目的 评价茶色素不同剂量、不同疗程治疗高脂血症，尤其是高脂胆固醇血症（TC）和混合型高脂血症的疗效及安全性以及对甲襞微循环的影响。方法 172例患者随机分为A组和30例，服茶色素125mg1日3次，治疗1月；B组48例服茶色素125mg,1日3次，治疗2月；C组57例，服茶色素250mg,1日3次，治疗1月；D组37例，服茶色素250mg,1日3次治疗2月。结果 茶色素对各类高脂血症患者均有降脂作用（P＜0．05），并有改善甲襞微循环积分值的作用（P＜0．01）；不同剂量、不同疗程降脂疗效不尽相同，随疗程延长或剂量增加疗效有所提高。结论 茶色素有明显降低TC和升高HDL－C作用，同时有一定降低TG和LDL－C作用，并有改善甲襞微循环积分值的作用。适用于高脂血症，尤其是高脂固醇血症和混合型高脂血症的治疗。推荐剂量250mg,1日3次，疗程2个月以上。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…