辛伐他汀治疗老年高脂血症的疗效和安全性

目的观察辛伐他汀治疗老年高脂血症，特别是高胆固醇血症的疗效和安全性。方法选取58名老年高脂血症患者应用辛伐他汀20mg／d治疗，每3个月检查血脂、血尿常规、肝肾功能、肌酸激酶等生化指标1次．随访至少24个月，观察其调脂疗效和不良反应。结果辛伐他汀能使总胆固醇（TC）平均下降26．30％，低密度脂蛋白胆固醇（LDL—C）平均下降28．63％，甘油三酯（TG）平均下降16．38％，高密度脂蛋白胆固醇（HDL—C）平均上升8．16％；在随访期间，未发现有明显的不良反应出现。结论辛伐他汀有明显降低TC、LDL—C的作用，对TG也有一定降低作用，HDL—C则有一定升高作用；该药长期应用具有良好的安全性。

Efficacy and safety of simvastatin in treatment of hyperlipidemia in elder patients

Objective] To evaluate the efficacy and safety of simvastatin in hyperlipidemia of elder patients, especially in hypercholesterolemia. Methods] 58 elder patients with hyperlipidemia were treated with simvastatin 20 mg/d, serum lipids, blood routine, urine routine, liver function, kidney function and CK were measured once every 3 months during at least two years. Results] The simvastatin has reduced the levels of total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C) and triglycerides(TG) in average 26.30%, 28.63% and 16.38% respectively. The level of high-density lipoprotein cholesterol (HDL-C) was elevated in average 8.16%. The adverse reactions of simvastatin were not obvious during the follow-up. Conclusions] Simvastatin significantly reduces TC and LDL-C, reduces TG and slightly increases HDL-C. A good safety was observed after long time application of simvastatin.