普罗布考治疗高胆固醇血症的近期临床疗效观察

目的：评价普罗布考片（Probucol)应用于高胆固醇血症患者的有效性和安全性。方法：80例高胆固醇血症患者入选本研究（其中33例患者同时有高甘油三酯血症），连续服用普罗布考片4周，每天2次，每次500mg，用药后4周测定血清总胆固醇（TC），高密度脂蛋白（HDL－C），甘油三酯（TG）及低密度脂蛋白（LDL－C），结果：服用普罗布考片4周后，患者TC下降25．3％（P＜0．001），LDL－C下降30．8％（P＜0．001），HDL－C下降13．2％（P＜0．05）。伴有高甘油三酯血症患者的TG下降7．4％（P＞0．05），在本研究中，除有2例患者因为腹泻而退出研究，没有发现其他严重的副作用，结论：普罗布考片可以安全，有效的降低高胆固醇患者的TC，LDL－C和HDL－C。

Recent clinical efficacy of probucol in treating hypercholesteromic patients

Objective TO assess the efficacy and safety of probucol on hypercholesterolema Methods 80 hypercholesteromic patients(33 patients in concomitant with hypertrigly ceridemia)were selected for this study They were given probucol 500mg Bid for 4weeks Serum total cholesterol (TC),triglyceride(TG),high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol(LDL-C) were measured at 4 weeks after the treatment Results 4 weeks later,TC was decreased by 25 3%,(P<0 001);LDL-C was decreased by 30 8%,(P<0 001);HDL-C by 13 2%(P<0 05) In patients with hypertriglyceridemia,TGwas decreased by 7 4%(P>0 05),In this study,only two patients withdrew from the study because of moderate diarrhea,no other serious adverse effects were found Conclusion Probucol is an efficient and safe agent to decrease serum TC,LDL-C and HDL-C in hypercholesteromic patients