踝臂指数与冠状动脉复杂病变的相关性研究

目的探讨踝臂指数（ABI）与冠状动脉（冠脉）病变程度的关系。方法对纳入研究的185例患者收集其基本资料、测量ABI、行冠脉造影,ABI〈0．9者为研究组（52侧）,ABI≥0．9者为对照组（133例）,应用多变量Logistic回归分析两组ABI与冠心病危险因子及冠脉病变程度的相关性。结果两组的病变血管支数比较,两组3支病变、B2／C型复杂病变例数比较,差异均有统计学意义（P〈0．01）;多个心血管危险因子与ABI〈0．9存在相关性,ABI〈0．9是冠脉3支病变及B2／C型复杂病变的独立预测因子（OR值分别为3．845、3．012）。结论ABI〈0．9一定程度上能够预测冠脉复杂病变（3支病变及B2／C型复杂病变）。     

简易踝肱指数测量值与冠心病发病相关性研究

目的 探讨经冠状动脉造影证实的冠心病(CHD)人群踝肱指数(ABI)的临床意义.方法 对2006年6-9月间在本院门诊就诊的60名经冠状动脉造影或心电图临床证实心肌梗死的患者及63名经冠状动脉造影或心电图临床证实冠状动脉未发生病变的患者,采集一般临床资料,心血管危险因素,采用右侧肢体踝肱动脉收缩压之比的简易测定方法,计算ABI值进行相关性分析.结果 冠心病组ABI<0.9发生率较对照组差异有统计学意义(P<0.05),ABI<0.9发生率冠心病组/健康对照组:38.3/14.3%,其中经冠状动脉造影证实有3支以上冠状动脉病变的ABI<0.9发生率为:62.5%.结论 简易ABI测量可以作为基层很好的预测CHD高危患者的方法.     

联合踝臂指数和钙化积分判定老年冠脉3支病变的价值

目的 探讨联合应用踝臂指数（ankle-brachial index,ABI）和钙化积分(coronary artery calcium score,CACS)提高判定冠状动脉3支病变的价值。方法 选择连续96例行冠脉造影的老年患者,分别予ABI检测和64排CT检测CACS。结果 ABI<0.9、CACS>400判定冠脉3支病变敏感度分别为58％、64％,特异度分别为87％、86％,联合使用敏感度显著提高（85％）,特异度未明显降低（83％）。结论 ABI<0.9、CACS>400一定程度上能够判定老年人冠脉3支病变,联合使用判定价值更大。     

开展经皮冠状动脉成形术前后冠状动脉造影临床应用对比

目的:了解在开展冠状动脉成形水(PTCA)前后冠脉造影在年龄、性别、冠脉病变种类、冠脉粥样硬化情况及其造影适应症等方面的变化.方法:采用回顾性资料分析方法,比较上海中山医院开展PTCA前134例(A组)和开展PTCA后440例(B组)冠脉造影资料上述指标问的差别.结果:(1)60岁以上造影者B组明显高于A组(P<0.05),且B组年龄跨度大于A组.(2)急性心梗冠脉造影者乃明显高于A组(P<0.05),其中B组急诊冠脉造影占18.29%,心梗后早期冠脉造影占28.05%;陈旧性心梗A组明显高于B组(P<0.05).诊断性冠脉造影两组无差别(P>0.05).(3)冠脉病变A组以单支、简单的A型病变为主,B组以多支复杂的B型和C型多见(P<0.05).结论:开展PTCA之后冠脉造影例数显著增加,造影年龄跨度增加12岁,平均年龄上升6.7岁;60岁以上老年人所占比例提高26.05%,冠脉造影适应症较前扩大,但病变阳性率并未下降,冠脉病变趋向多支、复杂的B型和C型.     

测量踝臂指数对冠状动脉硬化程度和心血管事件的预测意义

目的研究踝臂指数(ABI)和冠状动脉硬化程度及预后的关系。方法选择2003年1月至6月在黑龙江省大庆市第一人民医院行选择性冠状动脉造影检查的住院患者111例,经冠状动脉造影证实有冠状动脉病变81例,冠状动脉正常30例。测量四肢血压后计算ABI。选择性冠状动脉造影(CAG),采用Gensini积分系统,对每支血管病变程度进行定量评定。对患者进行4年门诊随访。结果冠状动脉正常组(30例)的冠状动脉积分为0.43±10.85,ABI为1.14±0.21;单支病变组(33例)的冠状动脉积分为13.54±9.96,ABI为0.95±0.25;双支病变组(30例)的冠状动脉积分为24.26±11.26,ABI为0.96±0.29;三支病变组(18例)的冠状动脉积分为39.55±12.36,ABI为0.68±0.35。冠状动脉正常组和有冠状动脉病变组的ABI差异有显著性意义(P<0.01)。多元Logistic回归提示糖尿病病史增加、空腹血糖增高和冠状动脉积分增高与ABI呈负相关关系。ABI≥0.9组随访中有2例死亡,ABI<0.9组中有6例死亡(P=0.00367),ABI<0.9是冠心病死亡的预测因素。结论ABI是预测冠状动脉硬化程度和冠心病死亡的一种简单可靠的指标。     

踝臂指数与老老年患者冠状动脉狭窄程度的相关性研究

目的探讨老老年冠心病患者踝臂指数(ABI)与冠状动脉狭窄严重程度的相关性,评价ABI对冠状动脉狭窄严重程度的预测价值。方法连续入选78例冠状动脉造影的老老年患者(年龄≥80岁)进行研究,根据冠状动脉造影结果分为无病变者(8例)、单支病变患者(10例)、2支病变患者(14例)、3支或左主干病变患者(46例)。对所有患者进行ABI测量、病史采集及血液生化检测。结果 ABI与Gensini评分呈负相关;冠状动脉3支或左主干病变患者ABI显著降低,差异有统计学意义(P0.001),而无病变、单支病变、2支病变患者ABI差异无统计学意义;ABI对3支或左主干病变预测价值的ROC曲线下面积为(0.79±0.04,95% CI:0.69～0.85,P0.001);ABI≤0.9作为截断值预测3支或左主干病变具有较高的特异性(89.5%)和敏感性(53.6%)。结论老老年冠心病患者ABI与冠状动脉狭窄严重程度呈负相关,ARI≤0.9对预测冠状动脉3支和左主干病变具有较高的特异性和敏感性。     

踝臂指数与冠心病严重程度的相关性

目的研究踝臂指数(ABI)与冠心病严重程度的相关性并评价其预测价值。方法选择天津市咸水沽医院2011年10月至2013年7月以诊断和(或)治疗为目的而行冠状动脉造影的386例患者为研究对象,根据冠脉造影结果分为非冠心病组90例,单支病变组136例,双支病变组85例,三支病变组75例(左主干病变计入三支病变组),对比非冠心病组和冠心病组、单支病变组与双支病变组、轻度病变组和严重病变组的ABI差异。结果轻度病变组和严重病变组ABI存在显著差异,而非冠心病组和冠心病组、单支病变组与双支病变组ABI无明显差异。结论 ABI在严重冠心病和非严重冠心病患者间存在显著差异,ABI≤0.9对三支病变有很好的预测价值。     

踝臂指数对冠状动脉狭窄程度预测价值的临床分析

目的本研究目的是通过与冠状动脉造影和心脏CT冠脉成像结果的相关性分析,评价踝臂指数(ABI)对临床冠心病病人危险程度预测的意义。方法收集曾经做过冠状动脉造影或心脏CT冠脉成像的病人76例,运用Gensini积分系统,将各组病人冠状动脉病变程度进行评分。并对其进行踝臂指数测量,分析踝臂指数与冠状动脉病变程度的相关性。结果三支病变组ABI(0.81±0.18),与正常组ABI(1.07±0.16,P0.01)和单支病变组ABI(0.98±0.12,P0.05)之间有显著性差异,两支病变组ABI(0.87±0.20)明显低于正常组ABI(1.07±0.16),有显著差异,P0.05。病人ABI与Gensini评分呈明显负相关。结论 ABI是一种简单易行、无创的检查方法,对冠心病病人有较好的预测价值。     

眼底动脉硬化、肱-踝脉搏波传导速度及踝臂指数对冠状动脉病变的预测价值

目的探讨眼底动脉硬化程度、肱-踝脉搏波传导速度（BaPwv）及踝臂指数（ABI）与冠状动脉造影（CAG）结果的相关性,了解三者在预测冠心病方面的价值。方法将472例行CAG患者分为4组。分别为为冠状动脉正常组（66例）、单支病变组（138例）、双支病变组（174例）和左主干或多支病变组（94例）。对所有患者进行眼底照相、BaPwv及ABI检测,同时收集病史、心电图、彩色多普勒超声心动图及生化检查等指标,评价眼底动脉硬化程度、BaPwv及ABI对冠状动脉病变程度的预测意义。结果眼底动脉无硬化的病例中有86%的患者冠状动脉正常;眼底动脉硬化在Ⅱ级以上的病例中有71%的患者冠脉病变在双支以上。单支病变组、双支病变组、左主干或多支病变组患者BaPwv较冠脉正常组显著增高（P〈0.05）。BaPwv在单支病变组[（11.53±1.96）m/s]、双支病变组[（12.45±1.23）m/s]、左主干或多支病变组[（14.20±3.24）m/s]间差异有显著统计学意义（P〈0.05）综合眼底动脉硬化,BaPwv,ABI及其他危险因素后,发现眼底动脉硬化Ⅱ级以上[OR=11.82,95%CI（7.65～14.91）,P〈0.01]及BaPwv〉14m/s[OR=10.02,95%CI（5.85～12.14）,P〈0.01]是冠脉多支病变的强有力预测因子。结论眼底动脉硬化及BaPwv均可反应冠脉病变的支数;眼底动脉硬化Ⅱ级以上及BaPwv〉14m/s是预测冠状动脉病变程度的早期指标,是冠脉左主干或多支病变的强有力预测因子。     

脂蛋白相关磷脂酶A2水平与冠状动脉病变严重程度的关系

目的 探讨脂蛋白相关磷脂酶A2(Lp-PLA2)水平与冠状动脉(冠脉)病变严重程度的相关性.方法 检测344例疑诊为冠状动脉疾病(CAD)患者血浆Lp-PLA2,并行冠脉造影,以病变支数及评分评价冠脉病变程度,并分析与Lp-PLA2水平之间的关系.结果 无CAD者(冠脉评分=0分)与CAD者Lp-PLA2水平差异有统计学意义[(211±47)ng/ml与(245+59)ng/m1](u=5.99,P＜0.05);不同冠脉病变支数、冠脉评分与Lp-PLA2水平闻差异有统计学意义,3支病变和2支病变组均高于1支病变组[(254±66)ng/ml、(247+57)ng/ml和(230±50)ng/m1](F=9.98、H=29.09,均P＜0.05);在排除影响因素后,经多元逐步回归分析显示,Lp-PLA2是冠脉病变的危险因子.结论 血浆Lp-PLA2水平与冠状动脉病变呈正相关.     

青年冠心病患者心血管病危险因素与冠状动脉病变程度的相关性分析

目的 探讨青年冠心病患者心血管疾病危险因素与冠状动脉（冠脉）造影病变程度相关性.方法 疑似青年冠心病患者（≤45岁）行冠脉造影住院病例91例,经冠脉造影确诊冠心病患者67例,排除冠心病患者24例.冠脉造影病变程度由病变支数和病变Gensini总积分表示.危险因素包括性别、高血压病、吸烟、饮酒、2型糖尿病、血脂异常、肥胖.采用单因素和多因素分析.结果 （1）单因素分析显示,在病变程度不同的各组间比较,随各组中存在单个危险因素病例百分率的增加,冠脉造影病变支数和病变Gensini总积分随之增加.（2）多因素Logistic回归分析（前进法）显示,高LDL-C为冠脉造影诊断冠心病最显著的独立相关危险因素,其他危险因素依次为男性、吸烟、高血压病、2型糖尿病、低HDL-C、肥胖和饮酒.结论 高LDL-C是冠脉造影诊断冠心病最显著的独立相关危险因素,但其他危险因素如男性、吸烟、饮酒、2型糖尿病、低HDL-C、高血压病和肥胖亦不可忽视,各危险因素在不同性别中危险程度有所不同.     

Associations Between Plasma Kinin B1 Receptor Levels and the Presence and Severity of Coronary Artery Disease

Aim: Kinin B1 receptor (KB1R) was shown to be up-regulated in human carotid atherosclerotic lesions. Serum KB1R levels were also reported to be high in patients with stroke. However, KB1R deficiency increased atherosclerotic lesions. Therefore, the role of KB1R in atherosclerosis remains unclear. Moreover, no study has reported blood KB1R levels in patients with coronary artery disease (CAD). Methods: We measured plasma KB1R levels in 375 patients undergoing coronary angiography. The severity of CAD was represented as the numbers of ＞50% stenotic vessels and segments and the severity score. Results: CAD was found in 197 patients, of whom 89 had 1-vessel disease (1-VD), 62 had 2-VD, and 46 had 3-VD. Plasma KB1R levels were higher in 197 patients with CAD than in 178 without CAD (median 83.3 vs. 73.7 pg/mL, p ＜0.01). A stepwise increase in KB1R levels was found depending on the number of stenotic vessels: 77.1 in 1-VD, 87.8 in 2-VD, and 88.5 pg/mL in 3-VD ( p ＜0.025). A high KB1R level (＞90.0 pg/mL) was present in 30% of patients with CAD(-), 39% of 1-VD, 50% of 2-VD, and 48% of 3-VD ( p ＜0.025). KB1R levels correlated with the number of stenotic segments and the severity score (r=0.14 and r=0.17, p ＜0.01). In multivariate analysis, KB1R levels were an independent factor associated with CAD. Odds ratio for CAD was 1.62 (95%CI=1.02-2.58) for high KB1R level ＞90.0 pg/mL. Conclusion: Plasma KB1R levels in patients with CAD were high and were associated with the presence and severity of CAD independent of atherosclerotic risk factors.     

冠状动脉造影患者心血管病危险因素与冠状动脉病变程度的相关性分析

目的探讨心血管疾病危险因素与冠状动脉造影病变程度相关性。方法入选行冠状动脉造影住院病例920例,其中确诊冠心病患728例(占79．13％),排除冠心病患192例(占20．87％)。冠状动脉造影病变程度由病变支数,经造影是否诊断冠心病及病变Gensini总积分表示。危险因素包括性别、年龄、高血压病、吸烟、2型糖尿病、血脂异常、高尿酸。采用单因素和多因素分析。结果(1)单因素分析显示,在病变程度不同的各组间比较,随各组中存在单个危险因素病例百分率的增加,冠状动脉造影病变支数和病变Gensini总积分随之增加。(2)多因素Logistic回归分析(前进法)显示,高LDL-C为冠状动脉造影诊断冠心病最显的独立相关危险因素(OR=2．816,95％可信区间1．903,4．167,P=0．001),其他危险因素依次为男性、吸烟、2型糖尿病、低HDL-C、高血压病、高尿酸血症和增龄。性别分组后分别经多因素Logistic回归(前进法)分析显示,男性组中高LDL-C为冠状动脉造影诊断冠心病最显的独立相关的危险因素(OR=2．965,95％可信区间1．880,4．676,P=0．009)。女性分组中吸烟(OR=2．840,95％可信区间0．553,5．378,P=0．001)和高尿酸血症(OR=2．132,95％可信区间1．048,3．641,P=0．017)为冠状动脉造影诊断冠心病最显的独立相关的危险因素。结论高LDL-c是冠状动脉造影诊断冠心病最显的独立相关危险因素,在男性组中更为突出,但其他危险因素如男性、吸烟、2型糖尿病、低HDL-c、高血压病、高尿酸和增龄亦不可忽视,并且各危险因素在不同性别中危险程度有所不同,应该加以区别对待和重视。     

More coronary artery stenosis,more cerebral artery stenosis? A simultaneous angiographic study discloses their strong correlation

Cerebral artery stenosis (CAS) has the same pathogenesis as coronary artery disease (CAD), but the coexistence of these two diseases has been rarely reported. To detect coexistent CAS in CAD patients, we conducted a study of simultaneous coronary and cerebral angiography. Of the 663 consecutive newly diagnosed CAD patients who had not yet been explored to have CAS, 80 were admitted to undergo angiography of bilateral carotid and vertebral system during the same procedure. We defined significant vascular stenosis, either located intracranially or extracranially, as the lesions of diameter stenosis more than 50%. Association between carotid or vertebral stenosis and their potential risk factors were also analyzed. Of our patients, 18 (22.5%) had significant extracranial vascular stenosis, 14 (17.5%) suffered from intracranial stenosis, and 20 (25%) had both. Only 28 patients (35%) had no significant intracranial or extracranial stenosis. None of the demographic parameters as hypertension or diabetes showed significant differences between the cerebral patent group and the CAS group, except for the number of coronary stenotic vessels (1.71 ± 0.81 versus 2.69 ± 0.64, P < 0.001). The number of coronary stenotic vessels is correlated well to the number of cerebral stenotic lesions (r = 0.562, P < 0.001). Besides, 8 of the cerebral stenotic patients and 2 of the cerebral patent patients had ischemic stroke previously. We conclude the CAS is coexistent in more than half of the CAD patients in this study. Our study also implies a proportional increase in the severity of CAS to CAD severity.     

踝臂指数、颈动脉内中膜厚度对冠状动脉硬化早期预测价值

目的探讨踝臂指数（ABI）与颈动脉内中膜厚度（IMT）的相关性及其对冠心病的预测价值。方法随机选择150例行冠脉造影检查的患者行ABI、IMT测定,调查其年龄、性别、高血压史、糖尿病病史、吸烟史以及身高、体重,计算体重指数,并测量血压,化验血糖、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL—C）和高密度脂蛋白胆固醇（HDL—C）等指标。用SYNTAX积分评价冠状动脉的病变程度,分析在不同病变程度下ABI和IMT之间的相关性。分别用ABI和IMT预测冠心病,并比较两者诊断的可靠程度。结果①以SYNTAX评分判定,ABI除冠脉正常组和轻病变组间差异无统计学意义（p=O．126）外,其余各组间差异均有统计学意义（P〈0．01）,冠状动脉病变越严重,ABI越低。IMT除中、重病变组间差异无统计学意义（P=0．055）外,余各冠状动脉组问差异均有统计学意义（P〈0．05）,冠状动脉病变越严重,IMT值越大。②以SYNTAX积分为协变量,计算ABI与IMT的偏相关系数,两者为负相关（r=一0．499,P=0．000）。SYNTAX积分为分组变量情况下分析ABI和IMT的相关性,显示在冠脉有病变的情况下两者呈负相关。③分别作ABI、IMT预测冠心病的ROC曲线,ABI=0．95,预测冠心病的灵敏度为85．2％,特异度为75．3％;IMT=1．51mm,预测冠心病的灵敏度为77．4％,特异度为64．4％。结论ABI、IMT与冠状动脉硬化程度密切相关,冠脉病变患者ABI越低则IMT越厚。ABI和IMT两种检测方法均对冠状动脉病变程度的评估具有价值,且二者协同互补,可以改善无创检查的敏感性及特异性。ABI和IMT作为非侵入性检测,对筛查无症状冠心病患者及评估冠心病严重程度具有重要意义。     

稳定性冠心病患者循环内皮祖细胞与冠状动脉病变严重程度的分析

目的观察稳定性冠心病患者循环内皮祖细胞(EPCs)数量与冠状动脉病变严重程度的关系。方法对80例冠状动脉造影患者(排除急性冠状动脉综合征、心肌梗死)作病变严重程度及危险因素分析;以CD133/KDR作为EPCs标记物,用流式细胞仪检测患者的CD133/KDR双标记细胞数量。结果外周血EPCs数量与年龄、血清肌酐清除率(Ccr)、左室心肌重量指数(LVMI)呈负相关(P值分别=0.004,0.015,0.014);冠心病伴高血压患者较不伴高血压者EPCs数量显著减少(P=0.004)。冠状动脉造影阳性者EPCs数量较阴性者显著降低(P<0.01);EPCs数量与Gensini评分呈负相关(n=49,r=-0.305,P=0.039)。结论在稳定性冠心病患者循环EPCs数量与心血管危险因素及冠状动脉病变相关。     

老年人脂蛋白相关磷脂酶A2与冠心病冠状动脉病变程度及危险因素的关系

目的 观察老年人脂蛋白相关磷脂酶A2(Lp-PLA2)水平与冠心病冠状动脉造影病变程度及冠心病危险因素的关系. 方法 测定90例临床怀疑冠心病行冠状动脉造影老年患者Lp-PLA2、超敏C反应蛋白(hs-CRP),血脂等指标,根据冠状动脉造影结果以病变支数及Gensini积分评价冠状动脉病变程度,分析Lp-PLA2与冠心病的关系. 结果冠心病组Lp-PLA2水平较对照组明显升高[(352.7±129.0)μg/L与(204.0±59.7)μg/L,P<0.01].Lp-PLA2水平随着冠状动脉病变支数和Gensini积分的增加而升高.Lp-PLA2与年龄(r=0.25,P<0.05)、三酰甘油(r=0.33,P<0.01)、低密度脂蛋白胆固醇(r=0.27,P<0.05)、载脂蛋白B(r=0.36,P<0.01)呈正相关.在冠心病组,Lp-PLA2与年龄呈正相关(r=0.29,P<0.05).Stepwise回归分析结果显示Lp-PLA2与冠心病相关. 结论 冠心病患者Lp-PLA2水平升高,其水平的高低可能反映冠状动脉病变的严重程度.为冠心病的危险因素之一.     

维吾尔族和汉族冠心病危险因素与冠状动脉病变对照分析

目的：探讨新疆维吾尔族和汉族冠心病（CHD）患者危险因素及冠状动脉病变的差异。方法：连续收集经冠状动脉造影（CAG）确诊的冠心病住院患者268人，并将其分为维吾尔族CHD组（80例）和汉族CHD组（188例）。设计统一的调查表，分析对比两组CHD危险因素，冠状动脉病变特点和以超重为基础的危险因素聚集情况（高血压，糖尿病，高甘油三酯血症和低水平高密度脂蛋白4个危险因素）。结果：维吾尔族CHD组超重患者明显多于汉族组（P〈0．01），血高密度脂蛋白-胆固醇（HDL-C）水平降低患者明显多于汉族组（P〈0．05）；维吾尔族CHD组3个危险因素聚集患者明显多于汉族组（P〈0．05）；维吾尔族患者冠脉3支病变和狭窄程度为74％～99％者明显多于汉族组（P〈0．05）。结论：新疆维吾尔族CHD患者超重、低HDL-C者较汉族显著增多，且有多种危险因素者，冠状动脉病变范围、程度较汉族广而严重，需特别重视。     

Conventional risk factors of coronary artery disease in a tertiary care hospital of Chandigarh in Northern part of India

There are conflicting reports about the role of conventional risk factors in coronary artery disease from some of the studies in India. The present study tried to determine the association of conventional risk factors in patients with coronary artery disease (CAD) and correlate with findings on coronary angiography.

Material and methods

Study was conducted at the PGIMER in 1003 consecutive patients with angiographic proven coronary artery disease. They were assessed for cardiovascular risk factors like age, sex, history of smoking, diabetes, hypertension (physician diagnosed) and family history of CAD. Anthropometric data for height, weight, body mass index (BMI), waist circumference and waist hip ratio were recorded using standard methods. Lipid profile and blood sugar estimation was done.

Results

The mean age was 56 ± 10.8 years with 82.8% were males. Hypertension, diabetes mellitus, history of smoking, family history and dyslipidemia were present in 59.6%, 25.8%, 32%, 6.8%, and 56% respectively. Central obesity was seen in 75.6% of male (WHR > 0.90) and 88.3% of female (WHR > 0.80) patients. Single, double and triple vessel disease was present in 50.4%, 28.2% and 16% cases respectively. Types A, B and C lesions were seen in 32.7%, 41.3%, and 37.6% cases respectively. About two fifth (39.8%) cases presented with acute myocardial infarction, 22.4% with unstable angina/NSTEMI and 37.8% with chronic stable angina. Logistic regression analysis showed that diabetes, waist hip ratio and raised triglycerides were significantly associated with increasing severity of lesion. Further diabetes also showed significant association with increased vessel wall involvement. Health promotion programmes focusing on conventional risk factors and secondary prevention focusing on early diagnosis, management and lifestyle modifications may be the key interventions for prevention and control of CAD.     

2型糖尿病与冠状动脉病变程度的相关性分析

目的探讨冠状动脉病变程度与2型糖尿病(type 2 diabetes mellitus,T2DM)的相关性。方法收集9289例行诊断性冠状动脉造影疑诊冠状动脉疾病(coronary artery disease,CAD)的患者进行回顾性分析,以冠状动脉造影阳性(主要血管直径狭窄≥50%)作为诊断CAD的标准,确诊CAD者6119例(65.9%),未确诊CAD患者3170例(34.1%),其中合并T2DM的2150例(23.1%)患者作为观察组,未合并T2DM的7139例(76.9%)患者作为对照组。采用Gensini积分评价冠状动脉造影病变程度,并计数冠状动脉病变的支数。采用单因素方差分析及多因素回归分析评价糖尿病与冠状动脉狭窄程度间的关系。结果 2150例合并T2DM患者中确诊CAD患者1717例,占79.9%;7139例未合并T2DM患者中确诊CAD的患者4402例,占61.7%。糖尿病患者CAD患病率显著高于非糖尿病组(79.9%比61.7%,χ2=4.027,P<0.001),且冠状动脉病变程度更为严重,表现为患者平均病变支数更多(1.63±1.11比1.11±1.10,t=19.20,P<0.001)、Gensini积分更高(35.47±36.80比22.65±31.42,t=15.92,P<0.001);多因素Logistic回归分析显示糖尿病是CAD发生的的最强独立危险因素(OR值2.127,95%CI1.869～2.419,P<0.001)。结论糖尿病患者的CAD发病率明显高于非糖尿病组;糖尿病组患者冠状动脉狭窄程度更为严重;糖尿病与CAD发生的具有明显正相关性。