基于MURA编码孔成像测量Pu部件对称性的数值模拟分析

通过分析MURA编码孔成像技术的原理,实现了MLEM重建算法的源物体图像重建。使用数值模拟方法,分析了413keV单能γ面源的MURA编码板成像全过程,通过对比分析重建源物体分布与实际源物体分布,验证了重建算法及程序的正确性。并通过MNCP程序模拟假想的Pu部件模型,在编码孔成像过程中,像平面上射线投影强度分布、直接重建及简单扣本底重建源物体分布,从而论证了MURA编码孔成像测量Pu部件对称性的可行性。数值模拟结果表明,编码孔成像测量Pu部件对称性与小孔成像相比,在保护敏感信息和提高射线利用效率方面,具备一定的优势。     

高能γ光子成像针孔准直器的解析设计方法

在对高辐射环境进行射线源分布成像时,需要为γ相机设计专门的用于高能光子成像的针孔准直器。为了简化针孔准直器的设计过程,使用几个新的解析公式来描述准直器各参数与性能间的关系。首先,采用解析方法推导了更通用的有效孔径公式、角分辨率公式和几何相对效率公式;然后,与采用蒙特卡罗方法模拟计算得到的数值进行比较。结果表明,解析方法提供的计算结果在一定范围内准确可靠。因此,本工作使用的针孔准直器解析设计方法简单方便,物理图像清晰,具有一定的实用价值。     

多针孔成像近地太空核爆X射线测量方法研究

根据X射线多针孔成像的原理,搭建了地面模拟成像装置进行X射线成像实验,获得了像素能量沉积(灰度值)与X射线强度、像素位置与入射角之间的关系,验证了采用多针孔成像技术探测近地太空核爆的可行性,为今后采用编码孔成像技术探测近地太空核爆提供基础。     

高分辨率小动物SPECT成像系统的设计与性能评估

为实现低成本、高分辨率的小动物单光子发射断层成像(SPECT),设计了一种基于临床探测器和针孔准直器的小动物SPECT成像系统。综合考虑视野尺寸、空间分辨率和绝对探测效率等指标,分别给出了单针孔和七针孔准直器的两种最优化设计方案,并通过对比两种设计方案在全视野范围内的平均空间分辨率和探测效率,对成像性能进行了评估。结果表明,与单孔准直器相比采用七针孔准直器设计可同时获得更高的空间分辨率和探测效率。经蒙特卡罗模拟成像实验验证,该七针孔准直器在临床探测器上可达0.5mm级的超高空间分辨率,且成本远低于采用专用探测器的现有小动物SPECT系统。     

X射线源针孔成像系统优化设计研究

为提高X射线源针孔成像系统的性能,对成像能区为10~100 keV的X射线源针孔成像系统进行了优化设计研究。综合应用了理论分析和蒙特卡罗模拟的方法,首先根据X射线波长、准直器角响应和X射线穿透效应对针孔成像的不同影响结果设计了可有效控制成像分辨率和成像面积变化的船底型准直器,随后用蒙特卡罗方法对使用该准直器的针孔成像系统进行了模拟验证。结果表明,对于100 keV以下的X射线,经船底型准直器后,成像的空间分辨率和亮斑亮度较稳定,能得到相对准确的X射线源定位、定量信息。     

CMGA:一个利用钚的94-104keVγ和X射线非破坏分析其同位素丰度的软件

钚样品γ能谱94-104 keV能区中有22条X及γ射线可用来提供其同位素丰度信息.本文介绍我们开发的用来解析该能区的CMGA1.0(China Multiple Group Analysis,Version 1.0)软件.利用该软件分析当前我们所能取得的唯一的具有质谱分析结果的样品.其240Pu/(239Pu 240Pu)多次测量的平均值与质谱法给出的对应数值之比为1.004,相对标准偏差为1.4%.     

γ成像数值模拟与初步实验分析

基于Geant4模拟开发平台,对γ成像系统进行了被动式成像数值模拟,并用γ相机对标准密封γ点源进行辐射成像实验,初步分析了便携式γ射线成像系统的成像特点.结果表明:该系统成像效果与源强、距离、时间等密切相关,源强越强,距离越近,清晰成像所需时间也就越短,且可以准确定位γ放射源,精确热点分布定位.     

~(238)Pu低能光子源衰变γ能谱识别

利用同轴P型高纯锗探测器,对X荧光分析的~(238)Pu低能光子源进行γ能谱分析,并对~(233)Pa、~(224)Ra、~(212)Pb、~(212)Bi及~(208)Tl的特征γ射线进行分析,确定上述核素的来源。其中,~(233)Pa是生产~(238)Pu的原料237 Np的衰变产物,~(224)Ra、~(212)Pb、~(212)Bi及~(208)Tl均为生产~(238)Pu的副产物~(236)Pu的衰变子核。能量为350、440、844、1 014、1 130、1 266、1 368、1 454keV的γ射线是α粒子轰击源封装材料引起原子核库伦激发或γ射线照射周边环境引起核激发产生。进行效率刻度后,使用γ能谱法计算各放射性核素的活度,并根据放射性平衡计算各放射性核素的质量。通过对~(238)Pu源γ能谱的分析,建立计算放射性同位素活度与质量的方法。     

γ针孔照相测量放射性污染分布

介绍了一种测量设备γ放射性表面污染的新方法。利用γ射线的直线传播和与物质相互作用的特性，采用针孔成像原理，以＾２３８Ｕ作为针孔材料，通过模拟计算得到针孔的设计参数，并据此制作一视场角为６０°的针孔相机。利用此相机分别对γ污染源和污染设备成像，经计算机处理，将此二幅图像叠加起来，可以清楚地知识污染源在设备上的位置及其在相机处产生的剂量水平。该方法具有直观、清晰、工作人员受辐射剂量少的优点，测量结果可     

点源γ光子穿越特定形状屏蔽层的Monte Carlo计算与模拟

采用Monte Carlo方法对点源γ光子穿越球壳形屏蔽层的问题进行了蒙特卡罗计算与模拟,并用VC 编写了软件对光子运行过程进行模拟,通过对模拟结果γ能谱的分析,显示模拟结果能较好地反映实际光子的运动过程。利用所编软件对不同材料不同厚度的介质进行模拟,可得出厚度为4cm的铅做介质对光子的屏蔽效果较好。     

Monte-Carlo simulation of pinhole collimator of a small field of view gamma camera for small animal imaging

Needs in scintimammography applications,especially for small animal cardiac imaging,lead to develop a small field of view,high spatial resolution gamma camera with a pinhole collimator.However the ideal pinhole collimator must keep a compromise between spatial resolution and sensitivity.In order to design a pinhole collimator with an optimized sensitivity and spatial resolution,the spatial resolution and the geometric sensitivity response as a function of the source to collimator distance has been obtained by means of Monte-Carlo simulation for a small field of view gamma camera with a pinhole collimator of various-hole diameters.The results show that the camera with pinhole of 1 mm,1.5 mm and 2 mm diameter has respectively spatial resolution of 1.5 mm,2.25 mm and 3 mm and geometric sensitivity of 0.016%,0.022% and 0.036%,while the source to collimator distance is 3 cm.We chose the pinhole collimator with hole diameter size of 1.2 mm for our the gamma camera designed based on the wade-off between sensitivity and resolution.     

Pinhole collimator design for nuclear survey system

A conventional knife-edge collimator, which is widely used in gamma camera for medical diagnosis, is not suitable for nuclear imaging system because many scattering radiations near the pinhole aperture happen and blur image. A new pinhole collimator, which shapes a channeled aperture for reducing image degradation induced by the scattering radiations, is introduced and its characteristics are analyzed by Monte Carlo simulation. Resolutions defined as the full-width at half-maximum (FWHM) of point spread function and efficiencies are calculated about several pinhole diameters from 4 to 8 mm and channel heights from 2 to 10 mm. For this calculation, we assumed that ¹³⁷Cs radiation sources with 662 keV mono-energies enter into our designed collimator at the 1 m distance from the detector plane. The efficiencies and resolutions of the channeled collimator are compared with those of the conventional collimator. By comparison results, it is verified that the new collimator takes advantage more than the conventional collimator. The optimum channel height and diameter of the pinhole collimator from simulation results are also proposed and designed. We finally acquired nuclear image mounting this collimator in the nuclear survey system.     

Characteristics of parallel-hole and pinhole collimators for nuclear medicine imaging

In this paper,the spatial resolution and geometry sensitivity of parallel- and pin-hole collimators in compact gamma camera are presented,and quantitatively compared by GEANT4 code in Monte-Carlo library.The results show that the geometry sensitivity for pinhole collimator rapidly drops with increasing the gamma source-to- collimator distance(SCD);and for parallel-hole collimator,mildly.Meanwhile,the spatial resolution for pin-hole collimator mildly deteriorates;and for parallel-hole collimator,severely.The pin-hole collimator for close imaging objects has higher geometry sensitivity than parallel-hole collimator.Our findings are helpful for setting compact gamma camera collimators in nuclear medicine imaging.     

区域γ辐射定向监测仪准直器的设计

为区域γ辐射分布定向监测实验相机系统设计了一个针孔准直器。应用针孔准直器的解析公式,根据探测器内在分辨率和实验相机系统的预期分辨率,考虑探测器尺寸,确定了相机的焦距及准直器的张角;然后根据预期角分辨率计算有效孔径,得出孔径和孔深的范围;再利用蒙特卡罗方法模拟面源入射,在各种孔径和孔深组合中,挑选出透射和散射光子份额最小的组为最优组,对应孔径和孔深参数即为最优参数。     

Development of a low-energy high resolution X-ray camera for high-energy gamma photon background environments

Although a high-energy gamma camera can obtain images of ¹³⁷Cs distribution by detecting the 662-keV gamma photons, its spatial resolution is reduced because high-energy gamma photons penetrate the edge of the pinhole collimator. To solve this problem, we developed a low-energy X-ray camera that detects the characteristic X-ray photons (32–37 keV) that are emitted from ¹³⁷Cs to obtain high resolution images. We used a 45 × 45 × 1-mm-thick NaI(Tl) scintillator that was encapsulated in 0.1-mm-thick aluminum and optically coupled to a 2-inch square, position sensitive photomultiplier tube (Hamamatsu Photonics, PSPMT:H12700 MOD) as an imaging detector. The imaging detector was encased in a 2-cm-thick tungsten alloy container and a pinhole collimator was attached to its camera head. The spatial resolution and sensitivity were ～5 mm full-width at half-maximum and ～0.6 cps/MBq for the 1.5-mm pinhole collimator 10 cm from the collimator surface, respectively. We administered 5 MBq of ¹³⁷Cs to a soybean seedling, imaged the distribution of radionuclides for six hours, and successfully obtained a high resolution image of it with our developed X-ray camera. We believe our camera will be a powerful tool for such ¹³⁷Cs imaging in plants.     

高分辨micro-SPECT成像系统针孔准直器的优化设计

为了最大限度地减少γ射线在针孔准直器上的透射和散射效应,采用蒙特卡罗方法对单光子发射计算机断层(SPECT)成像系统使用的针孔准直器进行优化.模拟计算结果与实验测试得到的系统灵敏度和空间分辨率曲线相符,达到了高分辨小动物成像的要求.     

基于LaBr3(Ce)晶体耦合SiPM阵列的可变角分辨率伽玛相机的设计与研制

编码孔径成像技术由于探测效率高、信噪比高、角分辨率好、成像质量稳定可靠等优点而广泛应用于核安全、核设施的去污及退役的测量、核医学等领域。建立通过改变编码准直器和探测器之间距离进而实现可变角分辨的伽玛成像系统。整个成像系统主要由编码准直器、位置灵敏探测(position sensitive detector, PSD)、数据采集卡以及图像重建系统组成。该成像系统的编码准直器采用修正均匀冗余阵列(modified uniformly redundant array, MURA)编码方式,为了保障对较高能量射线的探测能力,编码准直器的材料采用含钨量90%的钨铜合金,PSD通过LaBr₃(Ce)晶体耦合SiPM阵列组成,重建算法采用的是直接互卷积算法,快速高效。测试结果显示,整个位置灵敏探测器的平均能量分辨率为4.96%(662 keV);该辐射成像系统可以准确地对Am-241、Cs-137、Co-60进行清晰成像,并通过改变编码准直器和探测器之间的距离成功分辨出两个Cs-137点源的位置。     

Quantification of the Multiplexing Effects in Multi-Pinhole Small Animal SPECT: A Simulation Study

Our goal is to study the trade-off between image degradation and improved detection efficiency and resolution from allowing multiplexing in multi-pinhole (MPH) SPECT, and to determine the optimal pinhole number for MPH design. We used an analytical 3D MPH projector and two digitized phantoms: the mouse whole body (MOBY) phantom and a hot sphere phantom to generate noise-free and noisy projections, simulating pinhole collimators fitted with pre-studied pinhole patterns. We performed three schemes to achieve different degrees of multiplexing: 1. Fixed magnification and detection efficiency; 2. Fixed detection efficiency and changed magnification; 3. Fixed magnification and changed detection efficiency. We generated various noisy data sets by simulating Poisson noise using differently scaled noise-free projections and obtained 20 noise realizations for each setting. All datasets were reconstructed using 3D MPH ML-EM reconstruction method. We analyzed the quantitative accuracy by the normalized-mean-square-error. We evaluated the image contrast for the hot sphere phantom simulation, and also the image noise by the average normalized-standard-deviation of certain pixels for different degrees of multiplexing. Generally, no apparent artifacts were observed in the reconstructed images, illustrating the effectiveness of reconstructions. Bias increased for increased degree of multiplexing. Contrast was not significantly affected by multiplexing in the specific simulation scheme (1). Scheme (2) showed that excessive multiplexing to improve image resolution would not improve the overall trade-off of bias and noise compared to no multiplexing. However, scheme (3) showed that when comparing to no multiplexing, the trade-off improved initially with increased multiplexing by allowing more number of pinholes to improve detection efficiency. The trade-off reached a maximum and decreased with further multiplexing due to image degradation from increased bias. The optimal pinhole number was 7 for a compact camera with size of 12 cm × 12 cm and 9 for a standard gamma camera with size of 40 cm × 40 cm in this scheme. We conclude that the gains in improved detection efficiency and resolution by increased multiplexing are offset by increased image degradations. All the aforementioned factors must be considered in the optimum MPH collimator design for small animal SPECT imaging.