3.0TMR胃癌扩散加权成像——单序列分次屏气与分序列单次屏气比较研究

目的 比较3.0 T MR单序列分次屏气与分序列单次屏气在胃癌扩散加权成像(diffusion weighted imaging,DWI)的信噪比(SNR)、对比噪声比(CNR)、表观扩散系数(ADC)值和伪影等方面的差异.资料与方法 对经胃镜病理证实的18例胃癌患者行术前MR DWI检查,均行单序列分次屏气与分序列单次屏气两次扫描,比较两种检查方法的SNR、CNR、ADC值及伪影等影响图像质量的因素,以及胃癌与正常胃壁ADC值之间的差异.结果 18例胃癌DWI图像上均显示为高信号,两种检查方法间正常胃壁及癌肿ADC测量差异无统计学意义(P＞0.05),而单次屏气DWI的SNR、CNR明显高于分次屏气扫描,单次屏气胃腔内自由水以及背景噪声信号强度明显低于分次屏气扫描,差异均有统计学意义(P＜0.05);单次屏气法DWI图像的呼吸运动及并行采集空间敏感性编码技术(ASSET)伪影明显减轻;胃癌ADC值与正常胃壁ADC值间比较差异有统计学意义(t=- 10.167,P＜0.001),胃癌组明显低于正常胃壁组ADC值.结论 3.0 T MR胃癌DWI中单次屏气图像质量明显优于分次屏气扫描,胃癌ADC值明显低于正常胃壁ADC值,具有很好的临床应用价值.     

小视野DWI在乳腺癌中的应用研究

目的 探讨小视野扩散加权成像(rFOV DWI)序列在乳腺癌中的应用价值.方法 25例乳腺癌分别行单次激发平面回波扩散加权成像(SS-EPI DWI)和rFOV DWI检查,比较两种序列的图像质量分级、表观扩散系数(ADC)值.结果 在其他技术参数相同的条件下,25例rFOV DWI图像质量平均评级为4.96,SS-EPI DWI为4.04,差异有显著统计学意义(Z=-4.413,P＜0.01).25例乳腺癌rFOV DWI平均ADC值1.084×10-3mm2/s,SS-EPI DWI平均ADC值1.211×10-3mm2/s,差异有显著统计学意义(t=4.856,P＜ 0.01).结论 rFOV DWI具有图像分辨率高、变形小的优势,可以在乳腺癌诊断中发挥重要作用.     

前列腺和精囊磁共振扩散成像中EPI与SSFSE序列的比较

目的比较回波平面成像（EPI）与单次激发快速自旋回波（SSFSE）扩散成像序列测量前列腺和精囊的表观扩散系数（ADC）值. 资料与方法选择40例无前列腺和精囊疾病的男性,使用EPI和SSFSE扩散成像序列,行前列腺和精囊局部的磁共振扩散成像检查.两种脉冲序列的扩散敏感梯度（b）值均取1 000s/mm2.在工作站上测量前列腺中央带和外周带、精囊、膀胱、盆腔脂肪、直肠内气体的ADC值.对两种脉冲序列测得的组织ADC值使用配对t检验进行比较. 结果 EPI序列40名受检者中32例（80%）获得可测量ADC值的图像,SSFSE序列40例（100%）获得可测量ADC值的图像.两种扩散成像序列测得的膀胱、直肠内气体和盆腔脂肪的ADC值无统计学差异（P〉0.05）,而两种扩散成像序列测得的前列腺中央带、外周带、精囊的ADC值有统计学差异（P〈0.01）.EPI序列测得上述组织的ADC值较小. 结论不同扩散成像序列测得的前列腺中央带、外周带和精囊的ADC值有差异.     

Gd- DTPA对肝脏、脾脏及肾脏1.5T MR弥散加权成像的影响

目的:探讨钆喷酸葡胺(Gd-DTPA)在1.5T MR机对正常肝脏、脾脏、肾脏弥散加权成像(DWI)的影响.方法:30例健康体检者在1.5T MR机做上腹部MRI.除常规MR平扫和增强外,在增强前和增强后7min采用b值=500 s/mm2单次激发自旋回波平面成像序列(SE- EPI)分别行DWI扫描.测量增强前后肝脏、脾脏、肾脏在DWI上的信噪比(SNR)、脾脏-肝脏对比噪声比(CNR)、信号强度值和ADC值,并进行统计分析.结果:30例健康体检者检查结果均正常.正常肝脏、脾脏DWI的SNR、CNR、信号强度值、ADC值增强后7min与增强前比较差异无统计学意义(P＞0.05),肾脏DWI SNR、信号强度值、ADC值增强后7min较增强前降低,差异有统计学意义(P＜0.05).结论:Gd-DTPA增强后7min对肝脏、脾脏DWI的图像质量和ADC值无明显影响,而肾脏DWI的图像质量和ADC值降低.     

磁共振表观扩散系数对良恶性前列腺疾病的定量分析

目的 研究ADC值测量对前列腺增生、前列腺炎和前列腺癌的诊断作用.方法 收集经病理证实45例前列腺疾病患者,其中前列腺炎10例、前列腺癌13例、良性前列腺增生22例、10例健康志愿者.取病理前1个月内均行前列腺MRI 、DWI检查,采用单次激发EPI序列,b值为0 s/mm2 和 800 s/mm2.并测定血清PSA值.结果 腺体增生为主型、间质增生为主型、前列腺炎、前列腺癌和健康志愿者的ADC值分别为(1.91±0.15)×10-3 mm2/s、(1.37±0.14)×10-3 mm2/s、(1.89±0.19)×10-3 mm2/s、(1.17±0.17)×10-3 mm2/s 、(2.11±0.28)×10-3 mm2/s,组间有统计学差异(F=49.032,P=0.00 ,one-way ANOVA),两两比较(LSD)除前列腺炎组和腺体增生为主型良性前列腺增生组没有统计学差异外(P＞0.05),其余各组间两两比较有统计学差异( P＜0.05).结论 ADC值可以定量评价不同类型的前列腺增生、前列腺炎和前列腺癌,可以区分前列腺良、恶性疾病.     

MR扩散加权成像评估前列腺癌细胞密度的应用价值

目的 探讨磁共振扩散加权成像(DWI)及表观扩散系数(ADC)评价前列腺癌(PCa)细胞密度的价值.方法 使用Siemens Sonata 1.5 T高场强超导MR成像设备和腹部相控阵线圈,采用EPI序列对38例资料完整的前列腺癌病人行DWI检查.根据常规HE染色病理图片记录前列腺癌细胞密度.ADC与细胞密度相关性分析用Pearson相关分析.结果 PCa、前列腺增生区和正常外周带的平均ADC值分别为(49.32±12.68)×10-5 mm2/s,(86.73±26.75)×10-5 mm2/s,(126.25±27.21)×10-5mm2/s,差异有统计学意义(P＜0.05).PCa细胞密度平均值为12.9%,ADC值与细胞密度存在负相关性(r=-0.646,P＜0.05).结论 细胞密度是影响组织扩散特性的重要因素,ADC值能较好反映组织微观结构特点.     

联合PWI与DWI评价前列腺癌生物学特性的应用价值

目的:探讨联合磁共振灌注成像和扩散加权成像评价前列腺癌(PCa)生物学特性的临床应用价值。方法:49例经组织病理学证实的PCa患者,使用GE Echospeed 1.5T超导MR成像仪,均采用单次激发EPI序列行MR灌注成像(PWI)和扩散加权成像(DWI)。通过GE4.2工作站进行数据处理,以闭孔内肌作为灌注指标的内参照,计算不同兴趣区的相对负增强积分(rNEI),对比分析表观扩散系数(ADC)与rNEI的相关性。结果:PCa、前列腺增生(BPH)及正常外周带(PZ)的ADC值分别为2.282×10-3、2.559×10-3和2.892×10-3mm2/s,rNEI分别为6.44、3.01和1.29。PCa的rNEI、ADC值与BPH和PZ存在明显差异(P<0.05)。PCa的rNEI与ADC值大小存在负相关关系(r=-0.31,P=0.04),与PCa的Gleason评分、PSA及TNM分期存在正相关关系(P<0.05)。结论:DWI和PWI能从不同角度反映前列腺癌生物学特性,前列腺癌的rNEI与ADC有相关性,从影像学角度反映了组织灌注水平与微观结构的内在关系。     

磁共振弥散加权成像、T2加权成像及动态增强联合运用对前列腺癌的诊断价值

目的 探讨磁共振弥散加权成像(DWI)、T2加权像(T2WI)及动态增强(DCE)联合应用对前列腺癌的诊断价值.方法 100例前列腺疾病中前列腺癌49例和非癌病例51例(包括46例前列腺增生、3例外周带炎症及2例前列腺结核).所有病例在常规MR检查基础上加扫DCE及DWI序列,DWI的b值为800 s/mm2.比较T2WI、DCE、DWI及三者联合诊断前列腺癌的敏感性;统计分析前列腺组织与非癌组织的ADC值是否存在差异.结果 在DWI图像上,前列腺癌多呈明显高信号,6例局限于中央带前列腺癌得到正确诊断.前列腺癌组织的平均ADC值为(0.96±0.22)×10-3mm2/s,前列腺增生组织的平均ADC值为(1.56±0.23)×10-3mm2/s,两者之间有统计学差异(P＝0.001),但ADC值有小部分重叠.T2WI、DCE、DWI及三者联合诊断前列腺癌的敏感性分别为85.7%、87.8%、93.9%、100%.结论 T2WI、DCE及DWI三者联合应用可以弥补各自的缺点,提高前列腺癌诊断的敏感性.     

The effect of using Gd-DTPA as contrast medium on diffusion weighted imaging for extrahepatic cholangiocarcinoma

目的:探讨对比剂钆喷替酸葡甲胺(Gd-DTPA)对肝外胆管癌磁共振扩散加权成像(DWI)图像质量及表观扩散系数(ADC)的影响.方法:回顾性分析经病理证实并被DWI检出的57例肝外胆管癌患者的DWI图像资料,比较静脉注射对比剂Gd-DTPA增强前后及不同b值条件下肝外胆管癌病灶信噪比(SNR)、病灶与正常肝脏间对比信噪比(CNR)及ADC值的差异.结果:同一b值条件下,增强前后病灶SNR、CNR、ADC值的差异均无统计学意义(P＞0.05);增强前后肝外胆管癌病灶SNR、CNR及ADC值均随着b值的增大而降低,其差异均有统计学意义(P＜0.05).结论:肝外胆管癌病灶的DWI图像质量及ADC值不受Gd-DTPA影响,所以选择合适b值的增强后DWI序列是可行的.     

DWI评价TURP手术对前列腺不同组织影响的初步研究

目的:应用EPI-DWI评价TURP手术对前列腺不同组织弥散特性的影响,对DWI在疗效观察中的应用进行初步探讨。方法:分析46例经病理组织学证实的的前列腺癌病例,其中10例为TURP手术组,对照组为36例。使用GE E-cho-speed 1.5 T超导成像仪,联合应用盆腔相控阵线圈和直肠内表面线圈,DWI采用单次激发EPI进行扫描。标出前列腺癌、BPH和正常前列腺周围带的感兴趣区,计算其大小及体积及X、Y和Z轴三个方向计算ADC值,并由工作站处理产生ADC图。结果:前列腺癌TURP手术组分级、分期及大小体积高于非手术组(P<0.05)。前列腺相同组织的ADCx值在手术组与非手术组之间无显著差异(P值分别>0.05)。结论:TURP手术有促进前列腺癌进展的可能性;DWI及ADC值能准确地对TURP手术后前列腺癌做出诊断,但不能用于TURP术后评价。     

Diffusion-weighted imaging of normal and malignant prostate tissue at 3.0T

PURPOSE: To measure the apparent diffusion coefficient (ADC) of normal and malignant prostate tissue at 3.0T using a phased-array coil and parallel imaging, and determine the utility of ADC values in differentiating tumor from normal peripheral zone (PZ). MATERIALS AND METHODS: ADC values were calculated for 49 patients (tumor and PZ) with evidence of prostate cancer. Additionally, for nine asymptomatic volunteers, ADC values were determined for apparently normal central gland and PZ. A single-shot EPI diffusion-weighted imaging (DWI) technique with b = 0 and 500 seconds/mm2 was employed. RESULTS: ADC values were significantly lower for tumor (1.38 +/- 0.32 x 10(-3) mm2/second) than for patient PZ (1.95 +/- 0.50 x 10(-3) mm2/second, P < 0.001) and volunteer PZ (1.60 +/- 0.25 x 10(-3) mm2/second, P = 0.031). A considerable overlap of ADC values was noted between patient tissue types. CONCLUSION: DWI of the prostate at 3.0T in conjunction with a phased-array coil and parallel imaging allows ADC calculation of the prostate. ADC values were lower for tumors compared to normal-appearing PZ; however, there was considerable intersubject variability.     

Age-related and zonal anatomical changes of apparent diffusion coefficient values in normal human prostatic tissues

PURPOSE: To identify age-related changes and differences in the diffusion of water molecules within the prostate, through diffusion-weighted imaging (DWI) of the prostate gland in healthy adult Japanese men. MATERIALS AND METHODS: A total of 114 healthy male volunteers (mean age, 55 years; range, 24-81 years) underwent DWI of the prostate with a single-shot echo-planar imaging (EPI) sequence using b-factors of 0 and 1000 seconds/mm(2). Apparent diffusion coefficient (ADC) values of six locations in the peripheral zone (PZ) and two locations in the central gland (CG) were measured and correlations between region and age were examined. RESULTS: ADC values measured within both PZ and CG regions of the prostate showed a uniform distribution, and no significant differences were found between evaluated regions. However, mean ADC values were 1.64 +/- 0.27 x 10(-3) mm(2)/second for PZ and 1.26 +/- 0.12 x 10(-3) mm(2)/second for CG, representing a significant difference. In addition, significant positive correlations were identified between ADC values for both PZ and CG regions and subject age (r = 0.526, P < 0.0001; r = 0.190, P = 0.0431, respectively). CONCLUSION: ADC values within both PZ and CG regions of the prostate increase with age, and this must be taken into consideration when using DWI in the diagnosis of prostate cancer.     

Diffusion-weighted imaging of the spine with a non-carr-purcell-meiboom-gill single-shot fast spin-echo sequence: initial experience

BACKGROUND AND PURPOSE: To prospectively evaluate the signal-to-noise ratio (SNR) improvement in diffusion-weighted imaging (DWI) of the spine with the use of a newly developed non-Carr-Purcell-Meiboom-Gill (non-CPMG) single-shot fast spin-echo (SS-FSE) sequence and its effect on apparent diffusion coefficient (ADC) measurements. MATERIALS AND METHODS: Twenty-four patients were enrolled after written informed consent. DWI of the spine was obtained with an echo-planar imaging (EPI)-based sequence followed by a non-CPMG SS-FSE technique. SNR and ADC values were measured over a lesion-free vertebral corpus. A quality score was assigned for each set of images to assess the image quality. When a spinal lesion was present, contrast-to-noise ratio (CNR) and ADC were also measured. Student t tests were used for statistical analysis. RESULTS: Mean SNR values were 5.83 +/- 2.2 and 11.68 +/- 2.87 for EPI and non-CPMG SS-FSE DWI, respectively. SNR values measured in DWI using parallel imaging were found to be significantly higher (P < .01). Mean ADCs of the spine were 0.53 +/- 0.15 and 0.35 +/- 0.15 x 10(-3) mm(2)/s for EPI and non-CPMG SS-FSE DWI, respectively. Quality scores were found to be higher for the non-CPMG SS-FSE DWI technique (P < .05). Overall lesion CNR was found to be higher in DWI with non-CPMG SS-FSE. CONCLUSION: The non-CPMG SS-FSE technique provides a significant improvement to current EPI-based DWI of the spine. A study including a larger number of patients is required to determine the use of this DWI sequence as a supplementary tool to conventional MR imaging for increasing diagnostic confidence in spinal pathologic conditions.     

ADC mapping by means of a single-shot spiral MRI technique with application in acute cerebral ischemia.

Diffusion-weighted MRI based on single-shot echo planar imaging (EPI) has been established as a useful tool to study acute cerebral ischemia. However, EPI is prone to spatial distortion and ghosting artifacts. In this study, a pulse sequence for diffusion-weighted imaging (DWI) based on a single-shot spiral readout is presented. Using this technique, multislice apparent diffusion coefficient (ADC) mapping can be performed in an interleaved fashion with the same temporal resolution as EPI. Other advantages associated with ADC mapping by the single-shot spiral method include minimal ghosting artifacts, reduced spatial distortion, and capability to scan in arbitrary planes. This technique has been successfully tested in five normal volunteers and three stroke patients. It has been demonstrated that the single-shot spiral technique is capable of producing high quality DWI and ADC trace maps (128 x 128) in the axial, sagittal, and coronal planes, which facilitate clinical diagnosis.     

正常胰腺小视野高分辨DWI研究

目的:对比研究正常胰腺小视野扩散加权成像(rFOV DWI)和单次激发平面回波成像(SS-EPI)图像质量、ADC值及临床应用价值。方法:对20例胰腺健康志愿者分别行上腹部自由呼吸触发的SS-EPI DWI和rFOV DWI检查(b=600s/mm2)。从形态学方面,分别计算两种方法获得的胰腺头、体及尾部的ADC值,并进行统计学分析。结果:①rFOV DWI及SS-EPI DWI图像分辨力分别为0.55mm×0.55mm和1.56mm×1.56mm。②SS-EPI DWI获得正常胰腺头、体及尾部ADC值分别为(1.61±0.37)×10-3、(1.93±0.43)×10-3和(1.77±0.36)×10-3 mm2/s;rFOV DWI获得正常胰腺头、体及尾部ADC值分别为(1.10±0.48)×10-3、(1.21±0.38)×10-3和(1.11±0.34)×10-3 mm2/s。符号秩检验表明两种方法获得的胰腺头、体及尾部ADC值间差异无统计学意义(s=5,P=0.700>0.05)。③Wilcoxon秩和分析表明SS-EPI DWI获得的胰腺头、体及尾部ADC值间差异具有统计学意义(χ2=6.226,P=0.045<0.05),而rFOV DWI获得的胰腺头、体及尾部ADC值间差异无统计学意义(χ2=1.970,P=0.373>0.05)。结论:rFOV DWI较SS-EPI DWI图像分辨力高,且胰腺组织及总管显示更为清楚;统计学分析表明rFOV DWI获得的胰腺ADC均值不随胰腺形态学区域发生显著变化,具有较好的稳定性,而SS-EPI DWI获得的ADC均值在胰头部最小,胰体部最大,且差异具有统计学意义;较高分辨力和稳定的ADC测量值,将使rFOV DWI在胰腺疾病早期及准确诊断等方面发挥重要作用。     

Diffusion-weighted imaging of the sellar region: A comparison study of BLADE and single-shot echo planar imaging sequences

Purpose

The purpose of this study is to compare BLADE diffusion-weighted imaging (DWI) with single-shot echo planar imaging (EPI) DWI on the aspects of feasibility of imaging the sellar region and image quality.

Methods

A total of 3 healthy volunteers and 52 patients with suspected lesions in the sellar region were included in this prospective intra-individual study. All exams were performed at 3.0 T with a BLADE DWI sequence and a standard single-shot EP-DWI sequence. Phantom measurements were performed to measure the objective signal-to-noise ratio (SNR). Two radiologists rated the image quality according to the visualisation of the internal carotid arteries, optic chiasm, pituitary stalk, pituitary gland and lesion, and the overall image quality. One radiologist measured lesion sizes for detecting their relationship with the image score.

Results

The SNR in BLADE DWI sequence showed no significant difference from the single-shot EPI sequence (P > 0.05). All of the assessed regions received higher scores in BLADE DWI images than single-shot EP-DWI.     

Diffusion‐weighted imaging of the liver: Comparison of navigator triggered and breathhold acquisitions

Purpose

To compare a free breathing navigator triggered single shot echoplanar imaging (SS EPI) diffusion‐weighted imaging (DWI) sequence with prospective acquisition correction (PACE) with a breathhold (BH) DWI sequence for liver imaging.

Materials and Methods

Thirty‐four patients were evaluated with PACE‐DWI and BH DWI of the liver using b‐values of 0, 50, and 500 s/mm². There were 29 focal liver lesions in 18 patients. Qualitative evaluation was performed on a 3‐point scale ( 1 - 3 ) by two independent observers (maximum score 9). Quantitative evaluation included estimated SNR (signal to noise ratio), lesion‐to‐liver contrast ratio, liver and lesion apparent diffusion coefficients (ADCs), and coefficient of variation (CV) of ADC in liver parenchyma and focal liver lesions (estimate of noise contamination in ADC).

Results

PACE‐DWI showed significantly better image quality, higher SNR and lesion‐to‐liver contrast ratio when compared with BH DWI. ADCs of liver and focal lesions with both sequences were significantly correlated (r = 0.838 for liver parenchyma, and 0.904 for lesions, P < 0.0001), but lower with the BH sequence (P < 0.02). There was higher noise contamination in ADC measurement obtained with BH DWI (with a significantly higher SD and CV of ADC).

Conclusion

The use of a navigator echo to trigger SS EPI DWI improves image quality and liver to lesion contrast, and enables a more precise ADC quantification compared with BH DWI acquisition. J. Magn. Reson. Imaging 2009;30:561–568. © 2009 Wiley‐Liss, Inc.     

Readout-segmented EPI for rapid high resolution diffusion imaging at 3 T

Readout mosaic segmentation has been suggested as an alternative approach to EPI for high resolution diffusion-weighted imaging (DWI). In the readout-segmented EPI (RS-EPI) scheme, segments of k-space are acquired along the readout direction. This reduces geometric distortions due to the decrease in readout time. In this work, further distortion reduction is achieved by combining RS-EPI with parallel imaging (PI). The performance of the PI-accelerated RS-EPI scheme is assessed in volunteers and patients at 3T with respect to both standard EPI and PI-accelerated EPI. Peripherally cardiac gated and non-gated RS-EPI images are acquired to assess whether motion due to brain pulsation significantly degrades the image quality. Due to the low off-resonance of PI-driven RS-EPI, we also investigate if the eddy currents induced by the diffusion gradients are low enough to use the Stejskal-Tanner diffusion preparation instead of the twice-refocused eddy-current compensated diffusion preparation to reduce TE. It is shown that non-gated phase corrected DWI performs equally as well as gated acquisitions. PI-driven DW RS-EPI images with substantially less distortion compared with single-shot EPI are shown in patients-allowing the delineation of structures in the lower parts of the brain. A twice-refocused diffusion preparation was found necessary to avoid blurring in the DWI data. This paper shows that the RS-EPI scheme may be an important alternative sampling strategy to EPI to achieve high resolution T2-weighted and diffusion-weighted images.     

MR背景抑制扩散加权成像在乳腺癌的应用

目的 探讨MR扩散加权成像(DWI)结合短时间反转恢复回波成像(STIR-EPI)背景抑制(BS)技术在乳腺癌成像的技术参数及其可行性.方法 回顾性分析26例乳腺癌的MR DWIBS测得各组织的表观扩散系数(ADC),利用三维最大强度投影(3D-MIP)重组及黑白反转技术,观察病变显示效果.观察乳腺痛DWI及DWIBS两种方法的显示率.对乳腺各组织的ADC值进行随机区组设计的方差分析,在乳腺癌与良性病变ADC值的比较中,采用t检验.对两种成像方法乳腺癌的显示率进行配对资料X2检验.结果 在扩散敏感因子(b)=800 mm2/s的图像中,乳腺癌多表现为高信号,其ADC值分别为:肿瘤实质(0.93±0.25)×10-3 mm2/s、瘤内坏死灶(2.06±0.17)×10-3 mm2/s、正常腺体(1.92±0.23)×10-3 mm2/s、转移性淋巴结(1.10 ± 0.14)×10-3mm2/s,各种组织间两两比较,差异具有统计学意义(P值均＜0.01).DWIBS经MIP重组及黑白反转技术,病变周围组织信号被抑制,得到类正电子发射体层成像(PET)图像.在乳腺癌中,DWIBS对肿瘤实质(92.3/)及转移性淋巴结(88.4/)的显示率要高于DWI序列(分别为57.6/和42.3/),差异有统计学意义(x2值分别为8.307、12.235,P均＜0.05).乳腺癌与良性病变ADC值分别为(1.092±0·17)×10-3和(2.154±0.53)×10-3mm2/s,差异有统计学意义(t=8.626,P＜0.05).结论 MRDWIBS在显示病灶方面有一定优势,应用DWI结合ADC值对乳腺癌的诊断具有临床应用前景.     

MRI联合DWI在强直性脊柱炎诊断中的价值

目的探讨MRI联合DWI对强直性脊柱炎(AS)的诊断价值。资料与方法搜集经修订纽约标准确诊的31例AS病例和25例正常对照组,两组均行两侧骶髂关节常规MRI横断位和冠状位抑脂T2WI、T1WI联合SE/EPI扩散加权成像(DWI)横断位扫描(b值0,600 s/mm2),观察两组骶髂关节的信号改变,测量表观扩散系数(ADC)值并作统计学检验。结果 31例病例组中的24例双侧或单侧骶髂关节面下骨质抑脂T2WI呈高信号,29例DWI呈高信号,25例对照组骶髂关节面下骨质T2WI、DWI均呈等信号,测量ADC值,病变组为(0.993±0.169)×10-3mm2/s,对照组为(0.649±0.395)×10-3mm2/s,病变组ADC值明显高于对照组(t=4.14,P<0.001),两者间差异有统计学意义。结论 MRI联合DWI对AS早期诊断有重要的临床价值。