| 负载顺铂的泊洛沙姆温敏凝胶用于小鼠宫颈癌的局部化疗 |
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| 引用本文： | 王通,柳时,张秀英.负载顺铂的泊洛沙姆温敏凝胶用于小鼠宫颈癌的局部化疗[J].应用化学,2017,34(10):1127-1133. |
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| 作者姓名： | 王通 柳时 张秀英 |
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| 作者单位： | 东北农业大学兽医学院兽医药理学与毒理学实验室 哈尔滨 150030;中国科学院长春应用化学研究所,高分子物理和化学国家重点实验室 长春 1300223;辽宁大成农牧实业有限公司 沈阳 110000 |
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| 基金项目： | 国家自然科学基金(81602715)资助项目 |
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| 摘 要： | 为了探讨载有顺铂的温敏凝胶对小鼠宫颈癌的局部化疗作用,制备了载有顺铂的泊洛沙姆温敏凝胶,并通过流变学、体外溶蚀、体外释放等技术手段表征其结构和性能,采用鼠源宫颈癌U14细胞制备了原位宫颈/阴道癌模型,将载药凝胶灌注入荷瘤鼠阴道,评价载药凝胶对小鼠宫颈/阴道癌的抑制作用。结果表明,载有顺铂的泊洛沙姆温敏凝胶经阴道给药后对小鼠宫颈/阴道癌的抑瘤率可达到63.1%,可有效抑制小鼠宫颈癌的生长,而系统安全性则远远高于静脉注射顺铂。因此,载有顺铂的温敏凝胶有可能成为一种新型的宫颈癌治疗剂型。
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| 关 键 词： | 顺铂 温敏凝胶 宫颈癌 泊洛沙姆 |
| 收稿时间： | 2017-02-28 |
Application of Cisplatin-loaded Thermosensitive Hydrogel in Local Chemotherapy of Cervical Cancer in Mice |
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| WANG Tong,LIU Shi,ZHANG Xiuying.Application of Cisplatin-loaded Thermosensitive Hydrogel in Local Chemotherapy of Cervical Cancer in Mice[J].Chinese Journal of Applied Chemistry,2017,34(10):1127-1133. |
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| Authors: | WANG Tong LIU Shi ZHANG Xiuying |
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| Affiliation: | Veterinary Pharmacology and Toxicology Laboratory,College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China;State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;DaCheng Farm(Liaoning) Limited Company,Shenyang 110000,China |
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| Abstract: | To explore the application of cisplatin-loaded thermosensitive hydrogel in the treatment of the cervical cancer in mice, cisplatin-loaded poloxamer thermosensitive hydrogel was prepared and characterized. The mouse uterine cervical cancer cell line U14 was injected into submucosa nearby the cervix in female mice. Drug-loaded hydrogel was infused into the vagina of tumor-bearing mice and the inhibitory effect was evaluated. The results show that the tumor inhibition rate is as high as 63.1% by vaginal administration of cisplatin-loaded poloxamer hydrogel, which presents a new formulation for the local drug delivery via vagina against cervical cancer. |
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| Keywords: | cisplatin thermosensitive hydrogel cervical cancer poloxamer |
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