| 槲皮素长循环纳米脂质体的制备与质量评价 |
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| 引用本文： | 蔡华,王刚,常明泉,杨光义,曾南,叶方.槲皮素长循环纳米脂质体的制备与质量评价[J].安徽医药,2011,15(4):426-428. |
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| 作者姓名： | 蔡华 王刚 常明泉 杨光义 曾南 叶方 |
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| 作者单位： | 湖北医药学院附属太和医院药学部,湖北,十堰,442000;湖北医药学院附属太和医院药学部,湖北,十堰,442000;成都中医药大学,四川,成都,610075;成都中医药大学,四川,成都,610075 |
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| 基金项目： | 湖北省教育厅优秀中青年基金 |
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| 摘 要： | 目的 制备槲皮素长循环纳米脂质体,并进行质量评价.方法 采用乳化蒸发-低温固化法制备槲皮素长循环纳米脂质体;以形态、粒径、包封率和载药量等作为纳米脂质体质量评价指标.结果 采用乳化蒸发-低温固化法制备的槲皮素长循环纳米脂质体平均粒径为172.63 nm,包封率为85.90%,载药量为23.55%.结论 该试验制备的槲皮...
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| 关 键 词： | 槲皮素 长循环纳米脂质体 制备 质量评价 |
Preparation of long circulating nanoliposomes of quercetin and quality evaluation |
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| CAI Hua,WANG Gang,CHANG Ming-quan,et al.Preparation of long circulating nanoliposomes of quercetin and quality evaluation[J].Anhui Medical and Pharmaceutical Journal,2011,15(4):426-428. |
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| Authors: | CAI Hua WANG Gang CHANG Ming-quan |
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| Affiliation: | CAI Hua1,WANG Gang1,2,CHANG Ming-quan1,et al(1.Department of Pharmacy,Taihe Affiliated Hospital of Hubei Medical College,Shiyan,Hubei 442000,2.Chendu TCM School,Chendu,Sichuan 610075) |
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| Abstract: | Aim To prepare long circulating nano-liposomes of quercetin(QUE-LCL)and to evaluate the quality.Methods QUE-LCL was prepared by emulsification evaporation-low temperature solidification method.Drug loading,encapsulation efficiency,mean diameter and span of dispersity were used as evaluation index of nano-liposomes.Results The mean diametre of QUE-LCL was 172.63 nm,the entrapment efficiency was 85.90% and the drug loading rate was 23.55%.Conclusion Preparation of QUE-LCL is good with high drug entrapment eff... |
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| Keywords: | quercetin long circulating nano-liposomes preparation quality evaluation |
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