多柔比星磁性葡聚糖微球的制备及特性检测

目的:制备多柔比星磁性葡聚糖微球并检测其特性。方法:采用吸附法制备多柔比星磁性葡聚糖微球。高倍显微镜观察微球粒径大小及形态,紫外分光光度法检测微球中多柔比星的含量,测定微球磁吸附率,计算求和值 S,确定最佳投料比(药物:载体),绘制药物微球体外释放曲线。结果:制备的多柔比星磁性葡聚糖微球最佳投料比为1:15,磁吸附率为100%。微球外形圆整,分散性好。多柔比星30 min 释放28%;60min 释放45%;6h 释放65%。结论:制备的多柔比星磁性葡聚糖微球缓释性好,磁响应性强,可作为一种治疗顽固性疼痛的靶向神经损毁剂。

Preparation and Characteristics Test of Adriamycin Magnetic Sephadex Microspheres for as a Neurolytic Drug

Objective:To study the preparation and characteristics of adriamycin magnetic sephadex microspheres.Method:Adri- amycin magnetic sephadex microspheres were prepared by adsorptive process.The mieropheres were observed by high power micro- scope,and the diameter of microspheres was measured,the content of adriamycin was measured by the method of ultraviolet speetro- photometer.The magneto-adsorption rate was observed.The value of S was calculated.The optimal ratio of drug and carrier was de- fined.The release curve of mierospheres drug was drawed in vitro.Result:The optimal ratio of adriamycin magnetic sephadex micro- spheres was 1:15.The magneto-adsorption rate of the mierospheres was 100%.The outline of microspbere was regular.The dispersivi- ty and fluidity were perfect.The percent of drug release from adriamyein magnetic sephadex mierospheres was about 28% during the first 30 min,45% during 60 min,and 65% during 6 hours.Conclusion:The prepared adriamycin magnetic sephadex microspheres has good properties of drug-targeting and drug sustain releasing,and could he a kind of targeting-neurolytic drug for the relief of intrac- table pain.