| 奥沙利铂联合氟尿嘧啶和亚叶酸钙治疗晚期结直肠癌的疗效观察 |
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| 引用本文： | 洪辉斌,徐洁平,姚伟.奥沙利铂联合氟尿嘧啶和亚叶酸钙治疗晚期结直肠癌的疗效观察[J].中国医药指南,2011,9(22):7-8. |
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| 作者姓名： | 洪辉斌 徐洁平 姚伟 |
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| 作者单位： | 广东省汕头市第二人民医院药剂科,广东汕头,515011 |
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| 摘 要： | 目的探讨奥沙利铂、5-氟脲嘧啶和亚叶酸钙联合治疗晚期结直肠癌的疗效及不良反应。方法 40例晚期结直肠癌患者均采用奥沙利铂联合5-氟尿嘧啶和亚叶酸钙治疗,治疗方案为:奥沙利铂130mg/m2静脉滴注4h,第1天;亚叶酸钙200mg/m2静脉滴注2h,第1～5天(在静脉滴注5-氟尿嘧啶之前),5-氟尿嘧啶400mg/m2静脉滴注4～6 h,平均用药4周期,2周期后进行疗效评价。结果 40例晚期结直肠癌患者中,完全缓解(CR)4例(10%),部分缓解(PR)18例(45%),稳定(SD)10例(25%),进展(PD)8例(20%),总有效率(ORR)为55%。不良反应为厌食疲乏、皮肤色素沉着、神经毒性、手足综合症、腹泻、恶心呕吐、肝功损害、白细胞下降,多数患者能耐受。结论奥沙利铂联合5-氟尿嘧啶和亚叶酸钙治疗晚期结直肠癌的疗效肯定,毒副反应小,患者能耐受,值得推广。
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| 关 键 词： | 奥沙利铂 亚叶酸钙 5-氟尿嘧啶 化疗 晚期结直肠癌 |
The Efficacy of Oxaliplatin Combined with Fluorouracil and Leucovorin for Treatment of Advanced Colorectal Cancer |
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| HONG hu-bin,XU Jie-ping,YAO Wei.The Efficacy of Oxaliplatin Combined with Fluorouracil and Leucovorin for Treatment of Advanced Colorectal Cancer[J].Guide of China Medicine,2011,9(22):7-8. |
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| Authors: | HONG hu-bin XU Jie-ping YAO Wei |
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| Affiliation: | HONG hu-bin,XU Jie-ping,YAO Wei(Department of Pharmacy,Shantou Second People's Hospital,Shantou 515011,China) |
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| Abstract: | Objective To evaluate the efficacy and toxicity of combination therapy of oxaliplatin,5-fluorouracil and leucovorin(OXA-LV5FU2) in advanced colorectal cancer.Method Total of 40 patients were received the combination therapy of oxaliplatin,5-fluorouracil and leucovorin,OXA 130mg/m2 iv 4hr d1,LV 200mg/m2 iv 2hr followed by 5-Fu 400mg/m2 iv 4-6hr d1-5 were given,for a mean of 4 cycles.It was estimated the effect after treated two cycles.Results In all of the patients,4 patients achieved CR(10%),18 PR(45%),10 S... |
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| Keywords: | Oxaliplatin(OXA) Leucovorin(LV) 5-fluorouracil(5-FU) Chemotherapy Advanced colorectal cancer |
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