| 托吡酯达稳态时对丙戊酸钠药动学的影响 |
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| 引用本文： | 何继红,许飞,孙红斌.托吡酯达稳态时对丙戊酸钠药动学的影响[J].中国医院药学杂志,2010(3). |
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| 作者姓名： | 何继红 许飞 孙红斌 |
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| 作者单位： | 绍兴市人民医院神经内科;四川省医学科学院.人民医院神经内科; |
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| 摘 要： | 目的:研究托吡酯(TPM)达稳态时添加单剂量丙戊酸钠(VPA)与单剂量VPA在血清及脑脊液(CSF)中药动学的主要药动学参数的变化,探索TPM达稳态时对单剂量VPA存在的药物相互作用及意义。方法:8只Beagle犬,随机分成2组,采取平行对照。A组给予单剂量VPA;B组给予TPM达稳态后添加单剂量VPA。采用气相色谱-质谱法检测TPM的药物浓度,荧光偏振免疫分析法检测VPA的药物浓度。结果:当TPM达稳态时添加单剂量VPA后,血清中VPA的MRT上升、tmax上升、Cmax下降,差异有显著性(P<0.05),在CSF中VPA的MRT上升t、max上升,差异有显著性(P<0.05),其余参数差异无显著性(P>0.05)。结论:TPM达稳态时添加单剂量VPA后,TPM可加快VPA在血清及CSF中的代谢,降低其药物浓度,可能在临床上具有当两药联合应用时需对剂量进行调整的指导意义。
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| 关 键 词： | 托吡酯 丙戊酸钠 药物相互作用 犬 脑脊液 |
Influence of toipramate reaching steady state on the pharmacokinetics of sodium valpration |
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| HE Ji-hong,XU Fei,SUN Hong-bin.Influence of toipramate reaching steady state on the pharmacokinetics of sodium valpration[J].Chinese Journal of Hospital Pharmacy,2010(3). |
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| Authors: | HE Ji-hong XU Fei SUN Hong-bin |
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| Affiliation: | HE Ji-hong1,XU Fei2,SUN Hong-bin2(1.Department of Neurology,shaoxing People\'s Hospital,Zhejiang Shaoxing 312000,China,2.Department of Neurology,Sichuan Academy of Medical Sciences Sichuan Provincial People\'s Hospital,Sichuan Chengdu 610072,China) |
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| Abstract: | OBJECTIVE To study the influence of topiramate(TPM) reaching steady state on the changes of pharmacokinetics of single dose of sodium valproate(VPA),and the concentration of sodium valproate in the serum and the cerebrospinal fluid for exploring the significance of sodium valpration when topiramate reached steady-state.METHODS 8 Beagle dogs(female4,male4)were randomly and averagely divided into two groups,using parallel control.The experiment design was as follows:group A:administrated single dose of VPA;gr... |
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| Keywords: | topiramate sodium valpration drugs interaction Beagle dogs cerebrospinal fluid |
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