| 5-氟尿嘧啶衍生物的合成与抗肿瘤活性研究 |
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| 引用本文： | 张杰,潘晓艳,张彦民.5-氟尿嘧啶衍生物的合成与抗肿瘤活性研究[J].中南药学,2011,9(6):413-416. |
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| 作者姓名： | 张杰 潘晓艳 张彦民 |
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| 作者单位： | 西安交通大学医学院药物研究所,西安,710061 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的寻找新型、高效的5-氟尿嘧啶衍生物类抗肿瘤化合物。方法设计、合成4个5-氟尿嘧啶衍生物,利用MTT方法测定这些化合物对4株肿瘤细胞的增殖抑制活性。结果 4个5-氟尿嘧啶衍生物均显示了较好的肿瘤细胞增殖抑制活性。结论 4个目标化合物对肿瘤细胞有较好的抑制活性,值得进一步研究。
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| 关 键 词： | 5-氟尿嘧啶衍生物 抗肿瘤 抗增殖活性 肿瘤细胞株 |
Synthesis and anticancer activity of 5-fiulorourail derivatives |
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| ZHANG Jie,PAN Xiao-yan,ZHANG Yan-min.Synthesis and anticancer activity of 5-fiulorourail derivatives[J].Central South Pharmacy,2011,9(6):413-416. |
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| Authors: | ZHANG Jie PAN Xiao-yan ZHANG Yan-min |
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| Affiliation: | ZHANG Jie,PAN Xiao-yan,ZHANG Yan-min(Institute of Materia Medica,School of Medicine,Xi'an Jiaotong University,Xi'an 710061) |
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| Abstract: | Objective To develop new anticancer agents with high anticancer activity from 5-flulorourail(5-FU) derivatives.Methods Four 5-FU derivatives were designed and synthesized.The in vitro antiproliferative activity against 4 cancer cell lines was evaluated by MTT assay.Results All the four 5-FU derivatives exhibited potent antiproliferative activity against the cancer cell lines.Conclusion These 5-FU derivatives have potent anticancer activity,are worth of further reaserch. |
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| Keywords: | 5-flulorourail derivative anticancer antiproliferative activity cancer cell line |
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