氟比洛芬酯联合曲马多用于腹腔镜胆囊切除术术后镇痛

目的观察氟比洛芬酯联合应用曲马多用于腹腔镜胆囊切除术多模式镇痛的作用效果。方法60例行腹腔镜胆囊切除术的患者,随机分成3组,每组20例。A组与B组术前15min静注氟比洛芬酯1mg/kg,C组手术结束前10min静注氟比洛芬酯1mg/kg;术毕A组静注生理盐水20mL,B组与C组静注曲马多1mg/kg。分别记录术毕给药后30min、1、2、4、8、12、24h的视觉模拟评分(VAS评分),不良反应及患者对镇痛治疗的总体满意度。结果B组切口痛、内脏痛、肩背痛VAS评分在术后24h内各时间点均低于A组和C组(P<0.05)。3组术后不良反应无显著差异(P>0.05)。患者对镇痛治疗总体满意度B组与A组、C组比较均有统计学意义(P<0.05)。结论氟比洛芬酯术前应用具有超前镇痛作用,同时联合应用曲马多,可以提高镇痛质量,是腹腔镜胆囊切除术患者术后镇痛的良好选择。

Effect of flurbiprofen axetil on multimodal analgesia in patients undergoing laparoscopic cholecystectomy

Objective To assess the multimodal analgesia effect of flurbiprofen axetil with tramadol for patients undergoing laparoscopic cholecystectomy.Methods Sixty patients were randomly allocated to three groups:15 minutes before operation,the patients in group A and B received intravenous of flurbiprofen 1 mg/kg,group C received flurbiprofen 1 mg/kg,10 min before the end of operation;and postoperatively group A received normal saline 20 mL,group B and C received tramadol 1 mg/kg.The effects of analgesia were assessed by visual analogue scale(VAS)at 30 min and 1,2,4,8,12,24 h after operation,and side effects,the overall satisfaction on analgesic therapy were assessed.Results Incisional pain,visceral pain and shoulder-tip pain VAS in group B were lower than those of A and C during 24 h after operation(P<0.05).Side effects in 3 groups were similar(P>0.05).The overall satisfaction on analgesic therapy were better in group B than that in group A and C(P<0.05).Conclusion Flurbiprofen axetil can produce preemptive analgesia,associated with tramadol postoperatively can lead to higher patients′ satisfaction,and is a good choice for the patients after laparoscopic cholecystectomy in multimodal analgesia.