葛丹蓝胶囊制备工艺研究

目的确定葛丹蓝胶囊提取、成型的最佳工艺。方法以干膏量、总黄酮为指标,采用正交实验优化葛丹蓝胶囊的最佳提取工艺;单因素考察成型工艺。结果人参粉碎以净粉量投料;葛根、丹参、桑叶、绞股蓝用体积分数为70%的乙醇回流提取2次,每次加12倍量溶剂,1.5h,制成干膏粉备用;人参细粉与上述干膏粉混匀后用体积分数为85%的乙醇制软材,16目筛制粒,装0号胶囊,即得。结论葛丹蓝胶囊的制备工艺合理,为其进一步药效和临床研究奠定了基础。

Study on the preparation of Gedanlan Capsules

Objective To optimize the extraction and preparation process of Gedanlan Capsules .Method An orthogonal experimental design was used to optimize the parameters of the extraction process on the basis of the dry extract yield and flavonoid contents , and the single factor experiment was used to optimize the parameters of the preparation process .Results Ginseng was crushed and the resulting powder was used . Pueraria lobata radix ,Salvia miltiorrhiza ,Lolium mori and Gynostemma pentaphyllum were extracted for two times with 70% ethanol ,the ratio of solvent to material was 12 ,the extraction time was 1 .5 h ,and the resulting extraction liquid was condensed into a dry paste for use .The ginseng powder and the dry paste powder were mixed with 85% eth‐anol for soft material ,and the granule was prepared by 16 mesh sieve and filled into the No .0 capsule for Gedanlan Capsules . Conclusion The preparation of Gedanlan Capsules is feasible .