依达拉奉注射液联合脑心通胶囊用于高血压脑出血术后的疗效观察

目的:观察依达拉奉注射液联合脑心通胶囊用于高血压脑出血立体定向微创术后的疗效。方法:采用随机对照法将124例高血压脑出血术后患者分为对照组(32例)、依达拉奉组(30例)、脑心通组(30例)和联合用药组(32例),对照组给予常规治疗,其余各组在常规治疗基础上给与相应药物。各组疗程均为28d。记录4组治疗前,治疗后14、28d格拉斯哥昏迷量表(GCS)评分,治疗前、后临床神经功能缺损程度评分,4组治疗后生活能力状态、脑水肿程度及不良反应发生情况。结果:治疗28d后,联合用药组GCS评分较对照组、依达拉奉组、脑心通组显著升高(P<0.01),依达拉奉组较对照组亦显著升高(P<0.05);治疗28d后联合用药组总有效率优于对照组、依达拉奉组和脑心通组(P<0.05);依达拉奉组优于脑心通组和对照组(P<0.05);各组脑水肿程度改善表明联合用药组优于对照组、依达拉奉组和脑心通组(P<0.01);依达拉奉组优于对照组(P<0.01)。治疗期间各组均未见明显不良反应。结论:依达拉奉注射液联合脑心通胶囊用于高血压脑出血微创术后的疗效与安全性较好,具有显著促进受损脑组织恢复、减轻脑水肿、改善预后的作用。

Efficacy Observation of Edaravone Injection Combined with Naoxintong Capsule for Hypertensive Cerebral Hemorrhage after Surgery

OBJECTIVE:To observe the therapeutic efficacy of Edaravone injection combined with Naoxintong capsule in the treatment of hypertensive cerebral hemorrhage after stereotactic mini-invasive surgery.METHODS:124 patients with hypertensive cerebral hemorrhage after surgery were randomly divided into control group(n=32),edaravone group(n=30),naoxintong group(n=30) and drug combination group(n=32).Patients in the control group were treated with routine therapy.Patients in the other three groups were treated with relevant drugs based on the routine therapy for 28 days.The Glasgow coma scales(GCS) before and 14 and 28 days after treatment,neurological deficit score before and after treatment,living ability state,the degree of cerebral edema and ADR after treatment were compared among 4 groups.RESULTS:GCS of drug combination group increased significantly 28 days after treatment,compared with control group,edaravone group,naoxintong group(P<0.01),there was significant difference between edaravone group and control group(P<0.05).The total effective rate of drug combination group was superior to control group,edaravone group and naoxintong group 28 days later(P<0.05),edaravone group was superior to naoxintong group and control group(P<0.05);the improvement of cerebral edema in drug combination group was better than that of control group,edaravone group and naoxintong group(P<0.01),and edaravone group was superior to control group(P<0.01).CONCLUSIONS:Edaravone injection combined with Naoxintong capsule contribute to relieve cerebral damage and cerebral edema,and promote the prognoses in patients with hypertensive cerebral hemorrhage after mini-invasive surgery.