| 隐丹参酮抗肿瘤药理作用机制研究进展 |
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| 引用本文： | 王加茹,徐宛婷,刘畅,孟令旗,李金钱,张翼,罗英花,金成浩.隐丹参酮抗肿瘤药理作用机制研究进展[J].现代药物与临床,2018,41(6):1160-1163. |
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| 作者姓名： | 王加茹 徐宛婷 刘畅 孟令旗 李金钱 张翼 罗英花 金成浩 |
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| 作者单位： | 黑龙江八一农垦大学 生命科学技术学院, 黑龙江 大庆 163319,黑龙江八一农垦大学 生命科学技术学院, 黑龙江 大庆 163319,黑龙江八一农垦大学 生命科学技术学院, 黑龙江 大庆 163319,黑龙江八一农垦大学 生命科学技术学院, 黑龙江 大庆 163319,黑龙江八一农垦大学 生命科学技术学院, 黑龙江 大庆 163319,黑龙江八一农垦大学 生命科学技术学院, 黑龙江 大庆 163319,黑龙江八一农垦大学 生命科学技术学院, 黑龙江 大庆 163319,黑龙江八一农垦大学 生命科学技术学院, 黑龙江 大庆 163319 |
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| 基金项目： | 黑龙江省科学基金资助项目（LC2015036）；黑龙江省大学生创新创业训练计划项目（201710223001） |
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| 摘 要： | 隐丹参酮是从中药丹参里提取的一种天然活性成分，具有多种药理作用，不仅能预防和治疗缺血性疾病、冠状动脉疾病和阿尔茨海默氏症，还具有良好的抗肿瘤活性。它通过抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抑制肿瘤转移和侵袭、抗新血管生成及调控活性氧水平等途径发挥抗肿瘤作用。对近年来研究的隐丹参酮的抗肿瘤活性和作用机制进行综述。
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| 关 键 词： | 隐丹参酮 抗肿瘤 细胞增殖 细胞凋亡 |
| 收稿时间： | 2017/10/28 0:00:00 |
Research progress on anti-cancer pharmacological mechanism of cryptotanshinone |
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| WANG Jiaru,XU Wanting,LIU Chang,MENG Lingqi,LI Jinqian,ZHANG Yi,LUO Yinghua and JIN Chenghao.Research progress on anti-cancer pharmacological mechanism of cryptotanshinone[J].Drugs & Clinic,2018,41(6):1160-1163. |
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| Authors: | WANG Jiaru XU Wanting LIU Chang MENG Lingqi LI Jinqian ZHANG Yi LUO Yinghua and JIN Chenghao |
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| Affiliation: | College of Life Science & Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China,College of Life Science & Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China,College of Life Science & Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China,College of Life Science & Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China,College of Life Science & Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China,College of Life Science & Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China,College of Life Science & Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China and College of Life Science & Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China |
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| Abstract: | Cryptotanshinone is a natural compound isolated from the plant Salvia miltiorrhiza Bunge. It has many pharmacological effects, including prevention and treatment of acute ischemic stroke, coronary artery disease, Alzheimer''s disease and anti-cancer. Recent studies have been shown that cryptotanshinone also could inhibit proliferation and induce apoptosis of cancer cells, inhibit migration, invasion and angiogenesis of tumor cells, and regulating the levels of reactive oxygen species to exert antitumor pharmacological activity. This study will review the antitumor pharmacological activity and the mechanism of cryptotanshinone. |
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| Keywords: | cryptotanshinone anti-tumor cell proliferation cell apoptosis |
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