| 几种海洋生物多糖对疫苗免疫效果的影响比较 |
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| 引用本文： | 张慧,朱伟,王学辉,沈俊,章建程,刘永德.几种海洋生物多糖对疫苗免疫效果的影响比较[J].海军医学杂志,2008,29(4):291-294. |
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| 作者姓名： | 张慧 朱伟 王学辉 沈俊 章建程 刘永德 |
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| 作者单位： | 1. 海军医学研究所,上海,200433
2. 上海交通大学农生院,上海,201104 |
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| 基金项目： | 海军医学研究所科研基金(05HY51) |
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| 摘 要： | 目的：探讨羊栖菜岩藻聚糖硫酸酯、珠母贝糖胺聚糖、乌贼墨肽聚糖等粉剂和注射液的免疫增强作用。方法：分别用3种多糖的粉剂和注射液饲喂和注射试验鸡。经鸡新城疫（ND）油乳剂疫苗免疫后，在第7、14、21天分别采集静脉血分离血清，采用J8微量血凝抑制试验（HI）检测NDHI抗体效价。结果：在饲喂多糖实验中，免疫后14d，肽聚糖组、岩藻聚糖组鸡NDHI抗体效价显著高于对照组（P〈0．05）；免疫后21d，岩藻聚糖组鸡NDHI抗体效价显著高于对照组（P〈0．05）。在注射多糖实验中，疫苗免疫后14、21d，岩藻聚糖50mg／妇体质量组NDHI抗体效价显著高于对照组（P〈0．05）；免疫后7、14、21d，岩藻聚糖100mg／kg体质量组NDHI抗体效价显著、极显著高于对照组（P〈0．05或P〈0．01）。结论：饲喂和注射实验显示，在3种多糖中，岩藻聚糖具有显著的免疫增强作用，且起效较快，维持的时间较长。
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| 关 键 词： | 海洋生物多糖 鸡新城疫 油乳剂疫苗 增强免疫 |
Effects of several halobios amylose extracts with Newcastle disease vaccine on the immunity |
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| ZHANG Hui,ZHU Wei,WANG Xue-hui,SHEN Jun,ZHANG Jian-cheng,LIU Yong-de.Effects of several halobios amylose extracts with Newcastle disease vaccine on the immunity[J].Journal of Navy Medicine,2008,29(4):291-294. |
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| Authors: | ZHANG Hui ZHU Wei WANG Xue-hui SHEN Jun ZHANG Jian-cheng LIU Yong-de |
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| Affiliation: | ZHANG Hui, ZH Wei, WANG Xue - hui, SHEN Jun, ZHANG Jian - cheng, LIU Yong - de (Naval Medical Research Institute, Shanghai 200433, China ) |
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| Abstract: | Objective: To investigate the effects of several halobios amylose powder and injection,including polysaccharide sulfate from alga S.fusiforme(Harv.) Setch],glycosaminoglycan from Pinctada margaritifera and peptidoglycan from Sepia on the immune response to Newcastle disease(ND) vaccine in chickens.Methods: Amylose extracts injections were respectively mixed with ND vaccine to form three variant ND vaccine injection and stabilities of the mixtures were all tested.And amylose extracts powders were respective... |
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| Keywords: | halobios amylose polycose Newcastle disease vaccine immunity |
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