生、制首乌醇提物对小鼠肝脏的影响

目的:观察炮制对何首乌醇提物不同剂量长期给药对小鼠肝脏的影响。方法:生首乌醇提物、制首乌醇提物按大、中、小剂量灌胃,连续60 d,对受试动物进行血液生化指标及病理组织学的检测。结果:生首乌醇提物小剂量肝指数、病理学积分与空白组比较差异有统计学意义(P<0.01),其他各给药组仅见趋势;生、制首乌醇提物各剂量组血液生化指标与空白组相比差异无统计学意义(P>0.05)。结论:生首乌醇提物临床等效量连续给药60d,对小鼠肝脏存在损伤。

Influence of ethanol extract of raw and processed Polygonum multiflorum on mice liver

Objective： To observe influence of ethanol extract of Polygonum multiflorum on mice liver before and after processing.Methods： Ethanol extracts of raw and processed Polygonum multiflorum at large,medium and small dosages were repeat administered to mice for a consecutive 60 days,then blood and tissues of the sacrificed animals were detected and compared.Results： Compared with the control group,the liver index and pathology of small dosage group were significantly different from that of the negative control group,while other groups only showed similar tendency.No significant difference was observed between the negative control group and other groups regarding to the biochemical indicators.Conclusions： Consecutive administration of ethanol extract of raw Polygonum multiflorum for 60 days can induce liver damages in health mouse.