| N-(3-三氟甲基苯基)维甲酰胺对人肺腺癌A549细胞分化和骨桥蛋白表达的影响 |
| |
| 引用本文： | 程英,王银凤,桂淑玉,周青,陈飞虎,汪渊.N-(3-三氟甲基苯基)维甲酰胺对人肺腺癌A549细胞分化和骨桥蛋白表达的影响[J].安徽医科大学学报,2011,46(1):1-5. |
| |
| 作者姓名： | 程英 王银凤 桂淑玉 周青 陈飞虎 汪渊 |
| |
| 作者单位： | 安徽医科大学第一附属医院呼吸内科,合肥,230022;安徽医科大学分子生物学实验室、生物化学教研室,安徽省/省部共建教育部重要遗传病基因资源利用和抗炎免疫药理重点实验室,合肥,230032;安徽医科大学药学院,合肥,230032 |
| |
| 基金项目： | 安徽省自然科学基金(编号:090413116); 国家自然科学基金(编号:30971226) |
| |
| 摘 要： | 目的 分析新合成的全反式维甲酸(ATRA)衍生物N-(3-三氟甲基苯基)维甲酰胺(NTFMP)对人肺腺癌细胞株A549体外增殖、分化及骨桥蛋白表达的影响.方法 以人肺腺癌细胞株A549为研究对象,分别给予不同浓度的ATRA及NTFMP进行干预,应用四甲基偶氮唑蓝比色(MTT)法测定A549细胞的增殖情况;酶动力学法检测...
|
| 关 键 词： | 肺肿瘤 腺癌 细胞增殖/药物作用 细胞分化/药物作用 骨桥蛋白质 癌胚抗原 信号传导 |
Effects of N-(3-trifluoromethyl-phenyl)retinamide on differentiation and expression of osteopontin of human pulmonary adenocarcinoma A549 cells |
| |
| Cheng Ying,Wang Yinfeng,Gui Shuyu,et al.Effects of N-(3-trifluoromethyl-phenyl)retinamide on differentiation and expression of osteopontin of human pulmonary adenocarcinoma A549 cells[J].Acta Universitis Medicinalis Anhui,2011,46(1):1-5. |
| |
| Authors: | Cheng Ying Wang Yinfeng Gui Shuyu |
| |
| Affiliation: | Cheng Ying,Wang Yinfeng,Gui Shuyu,et al(Dept of Respiratory Medicine,The First Affiliated Hospital of Anhui Medical University,Hefei 230022) |
| |
| Abstract: | Objective To investigate the effects of ATRA derivant N-(3-trifluoromethyl-phenyl)-retinamide(NTFMP)on the differentiaton and expression of osteopontin(OPN)of human pulmonary adenocarcinoma A549 cells.Methods A549 cells were treated with ATRA and NTFMP,respectively.The proliferation of A549 cells was observed by MTT assay.The morphology of A549 was observed by light microscope and the diversity of carcinoembryonic antigen(CEA)was detected by kinetics analysis cytometry.The related protein expression was ana... |
| |
| Keywords: | lung neoplasms adenocarcinoma cell proliferation/drug effects cell differentiation/drug effects osteopontin carcinoembryonic antigen signal transduction |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
