| 银杏叶提取物对异丙肾上腺素诱导的大鼠心肌肥厚的影响 |
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| 引用本文： | 苟怀宇,陈艳秋,黄晶,邓昌明,刘地川,江永红.银杏叶提取物对异丙肾上腺素诱导的大鼠心肌肥厚的影响[J].重庆医科大学学报,2010,35(2). |
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| 作者姓名： | 苟怀宇 陈艳秋 黄晶 邓昌明 刘地川 江永红 |
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| 作者单位： | 重庆市渝北区人民医院心内科,重庆,401120;重庆医科大学附属第二医院心内科,重庆,400010 |
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| 摘 要： | 目的:研究银杏叶提取物(Extract of ginkgo biloba,EGb)对异丙肾上腺素(Isoprenaline,Iso)诱导的大鼠心肌肥厚的影响.方法:大鼠30只分为正常对照组、ISO模型组和EGb治疗组.测定全心重量指数(Heartweight/Body weight,HW/BW)、左心室重量指数(Left ventricle weight index,LVI);检测左心室心肌组织中丙二醛(Malondialdehyde,MDA)和超氧化物歧化酶(Superoxide dismutase,SOD)、谷光苷肽过氧化酶(Glutathione-SH pexoxidase,GSH-Px)、一氧化氮合成酶(Nitric oxide synthetase,NOS)活性.结果:ISO模型组的HW/BW、LVI、左心室MDA含量和诱生型NOS(Inducible nitric oxide synthase,iNOS)活性显著高于正常对照组(P<0.05),SOD、GSH-Px及结构型NOS(Constitutive nitric oxide synthase,cNOS)活性比正常对照组低(P<0.05);EGb治疗组左心室MDA含量、iNOS活性和心脏重量指数比ISO模型组低(P<0.05),SOD、GSH-Px和cNOS活性明显高于ISO模型组(P<0.05).结论:EGb对ISO诱导的心肌肥厚的发生有预防作用.
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| 关 键 词： | 银杏叶提取物 异丙肾上腺素 心肌肥厚 |
Effect of EGb on cardiac hypertrophy induced by isoproterenol in rat |
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| GOU Huai-yu,et al.Effect of EGb on cardiac hypertrophy induced by isoproterenol in rat[J].Journal of Chongqing Medical University,2010,35(2). |
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| Authors: | GOU Huai-yu |
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| Affiliation: | GOU Huai-yu,et al (Department of Cardiology,the People\'s Hospital of Yubei District in Chongqing) |
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| Abstract: | Objective:To study the effect of EGb on cardiac hypertrophy induced by isoproterenol in rats.Methods:30 rats were randomly divided into 3 groups:normal control group,ISO model group and EGb treatment group.The ratio of HW/BW and LVI were measured.MDA content of left ventricle and the level of SOD,GSH-Px and NOS activities in left ventricle were determined.Results:Compared with normal control group,the ratio of HW/BW,LVI and the content of MDA and iNOS activity in left ventricle were significantly increased(... |
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| Keywords: | Extract of ginkgo biloba Isoproterenol Cardiac hypertrophy |
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