脑震荡患者血清神经元特异性烯醇化酶的浓度和伤情分析

目的研究脑震荡患者血清神经元特异性烯醇化酶(NSE)的浓度是否可反映其伤情状况及预后.方法对69例临床确诊为脑震荡患者,用酶联免疫吸附测试法测定其血清NSE伤后24h内、3d NSE的浓度.患者随访至伤后3周,了解伤后有无脑震荡后综合症的存在,并对数据进行分析.结果伤后24h内血清NSE正常31例,发生脑震荡后综合症6例(19.3%);伤后24h内血清NSE增高38例,发生脑震荡后综合症31例(81.6%);伤后72h内血清NSE仍增高6例,发生脑震荡后综合症6例(100%).发生脑震荡综合症组血清NSE的浓度明显高于未发生组,差别有统计学意义(P<0.000).结论脑震荡患者血清神经元特异性烯醇化酶(NSE)的浓度可作为伤情判断及预后的生化指标.

The Analysis of the Lever of Serum Neuron-specific Enolase and Prognosis of Cerebral Concussion Patient

Objective The aim of this study was to investigate the connection between the lever of serum neuron-specific enolase（NSE） and prognosis of cerebral concussion patient. Methonds Sixty nine patients with cerebral concussion were included in this prospective study. Venous blood samples for NSE were taken within 24 hours after injury and 72 hours after injury and was test by Elisa test method, and the patient was monitor by follow-up visit until 3 weeks after the injury to confirm if post concussion syndrome happens or not. Results 6 cases with post concussion syndrome was found in the group of normal lever of NSE within 24 hours after injury which was 19.3% in 31 cases. But 31 cases was found in the grope of high lever of NSE which was 81.6% in 38 cases. There was 6 cases in the group of high lever NSE 72 hours after injury was found which showed 100% in 6 cases. And the concentration of NSE in the patient with post concussion syndrome was significantly higher than in those without post concussion syndrome which revealed a statistically significant association（P〈0.000）. Conclusion Serum concentration of NSE can be a biochemical criterion for determining condition and prognosis of cerebral concussion patient.