踝臂指数改善对心血管危险人群主要心血管事件发生率的影响

目的 评价踝臂指数（ankle-brachial index,ABI）的改善对患者主要心血管事件（major adverse cardiac events,MACE）发生率的影响.方法 选取2009年1月至2009年12月在成都军区昆明总医院行ABI检测异常的131例患者,根据其6个月之内ABI改善与否分组.随访两年,对两组患者2年的MACE发生情况进行分析.结果 在所有131例患者中,失访5例,有效入组例数126例,2年内共发生MACE事件22例.随访6个月时的△ABI＞0％患者入选68例（53.9％）为改善组,随访6个月时的△ABI≤0％患者58例（46.1％）入选未改善组.2年内,未改善组MACE事件为17例（29.3％）,改善组MACE事件为5例（7.4％）,两组比较,差异有统计学意义（P＜0.001）.结论 ABI的改变能够影响患者心血管疾病的发生率,提示ABI的持续监测对心血管危险患者心血管疾病发生率有重要的预测价值.

Effect of improvement in ankle brachial index on rates of major adverse cardiac events in patients with risk of cardiovascular disease

Objectives To assess the effect of improvement in ankle brachial index （ABI） on the rates of major adverse cardiac events （MACEs） in patients with risk of cardiovascular disease. Methods A total of 131 patients undergone ABI measurements from January 2009 to December 2009 in Chinese PLA Kunming General Hospital were enrolled in this study. They were divided into 2 groups according to the improvement of ABI in 6 months. After 2 years＇ follow-up, end- points of MACEs were recorded. Results During the 2-year follow-up period, 5 patients missed. Of the rest 126 patients, 22 patients experienced MACEs. After 6 months＇ follow-up, ABI had improved （△ABI〉0%） in 68 （53.9%） patients （improved group）, whereas it had not improved （△ABI ≤ 0% ） in 58 （46.1% ） patients （non-improved group）. During the follow-up, we observed 5 （7.4%） cardiovascular events in improved group and 17 （29.3%） events in non- improved group, the difference was significant （P〈0.001）. Conclusions An improvement in ABI can affect the rates of MACEs, which indicates that continually monitoring ABI has an important value in predicting rates of MACEs in patients with risk of cardiovascular disease.