| GHbA1c和hsCRP与高血压患者颈动脉粥样硬化程度的关系 |
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| 引用本文： | 李旭亮,王先梅,杨丽霞,周靓,郭传明,齐峰.GHbA1c和hsCRP与高血压患者颈动脉粥样硬化程度的关系[J].岭南心血管病杂志,2009,15(1). |
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| 作者姓名： | 李旭亮 王先梅 杨丽霞 周靓 郭传明 齐峰 |
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| 作者单位： | 1. 昆明医学院,昆明,650031
2. 成都军区昆明总医院心血管内科,昆明,650032 |
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| 摘 要： | 目的 研究糖化血红蛋白A1c(glycosylated hemoglobin A1c,GHbA1c)和高敏C反应蛋白(highsensitivity reactive protein C,hsCRP)与原发性高血压患者颈动脉粥样硬化程度的关系.方法 对152例原发性高血压3级患者进行颈动脉超声检查,并检测GHbA1c和hsCRP.按不同颈动脉超声结果分组后比较各组的CHbA1c和hsCRP乘积.结果 颈动脉超声检查结果合并颈动脉内膜增厚,尤其合并颈动脉斑块形成的原发性高血压患者血清hsCRP和HbA1c的乘积显著高于无颈动脉内膜增厚患者(F=8.893,P=0.001):血清hsCRP和HbA1c的乘积与原发性高血压患者颈动脉粥样硬化(IMT增厚或斑块形成)呈正相关(r=0.459,P=0.001).结论 糖耐量异常和炎症反应的联合作用,加重了原发性高血压患者动脉粥样硬化的程度.
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| 关 键 词： | 血红蛋白A 糖基化 C反应蛋白质 颈动脉疾病 高血压 |
Combined effects of glycohemoglobin A1c and high-sensitivity C-reactive protein on the carotid atherosclerosis in hypertensive Subjects |
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| Li Xu-liang,WANG Xian-mei,YANG Li-xia,ZHOU Liang,GUO Chuan-ming,QI Feng.Combined effects of glycohemoglobin A1c and high-sensitivity C-reactive protein on the carotid atherosclerosis in hypertensive Subjects[J].South China Journal of Cardiovascular Diseases,2009,15(1). |
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| Authors: | Li Xu-liang WANG Xian-mei YANG Li-xia ZHOU Liang GUO Chuan-ming QI Feng |
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| Affiliation: | 1.Kunming Medical College;Kunming 650031;China;2.Cardiovascular Department of Kunming General Hospital in Chengdu Military Area;Kunming 650032;China |
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| Abstract: | Objectives To investigate the joint effects of glycosylated hemoglobin A1c ( GHbA1c) and high-sensitivity C reactive protein (hsCRP) on carotid atherosclerosis in hypertensive subjects. Methods A total of 152 inpatients ( mean age 65 years) diagnosed grade 3 hypertension were enrolled. They underwent ultrasonographic evaluation of the carotid arteries. Measurements of hsCRP and HbA1c were performed in addition to common risk factors. According to the difference results of ultrasonographic evaluation of the ... |
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| Keywords: | glycosylated hemoglobin A1c high-sensitivity C-reactive protein carotid disease hypertension |
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