| 前S1抗原作为乙肝病毒复制指标的临床应用价值 |
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| 引用本文： | 焦付丰,陈振祥.前S1抗原作为乙肝病毒复制指标的临床应用价值[J].医学检验与临床,2008,19(4). |
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| 作者姓名： | 焦付丰 陈振祥 |
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| 作者单位： | 高唐县人民医院检验科 |
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| 摘 要： | 目的观察前S1抗原(PreS1Ag)作为乙肝病毒复制指标的临床应用价值。方法对462名慢性乙型肝炎患者用ELISA法检测PreS1Ag和血清HBV标志物(HBV-M),用荧光定量PCR法测定HBV-DNA含量。结果462例HBsAg阳性患者中PreS1Ag阳性304人,阳性率65.8%,显著高于HBeAg阳性率(34%)(P<0.01)。HBsAg、HBeAg、HBcAb阳性组PreS1Ag阳性率为79.1%,HBsAg、HBeAb、HBcAb阳性组PreS1Ag阳性率为44.1%,两组差异有显著性(P<0.01)。PreS1Ag阳性率与HBV-DNA阳性率高度符合,阳性符合率达80%。结论前S1抗原能够敏感地反映乙型肝炎病毒复制情况,尤其可以反映HBeAg阴性患者是否有病毒复制。是对乙肝病毒标志物的有益补充,可作为临床常规检测指标。
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| 关 键 词： | 前S1抗原 乙型肝炎病毒 复制 指标 临床 应用价值 |
Clinical application value of Pre S1 antigen as a marker for replication for HBV |
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| Jiao Fufeng,Chen Zhenxiang.Clinical application value of Pre S1 antigen as a marker for replication for HBV[J].Medical Laboratory Science and Clinics,2008,19(4). |
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| Authors: | Jiao Fufeng Chen Zhenxiang |
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| Affiliation: | Jiao Fufeng; Chen Zhenxiang(Gaotang People s Hospital; Shandong Gaotang 252800; China); |
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| Abstract: | Objective To observes the clinical application value of Pre S1 antigen(Pres1Ag) as Marker for Replication of HBV.Methods The Pres1Ag,HBV-M were measured with EIA;HBV-DNA was measured with PCR in462 cases of chronic hepatitis B.Results Compared with HBeAg posetive rate(34%),Pres1Ag positive rate(65.8%) Significantly increased in HBsAg positive grorp (P<0.01).The posetive rate of PreS1Ag were 79.1% in HBsAg、HBeAg、HBcAb positive grorp;And in HBsAg、HBeAb、HbcAb positive grorp were 44.1%.There was a Significan... |
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| Keywords: | PreS1Ag HBV Replication Marker Clinical application value |
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