| 热休克蛋白70大鼠脑弥漫性轴索损伤后神经元保护及修复作用研究 |
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| 引用本文： | 李红旗,章翔,费舟,吴景文,贺晓生,白红民.热休克蛋白70大鼠脑弥漫性轴索损伤后神经元保护及修复作用研究[J].中国组织工程研究与临床康复,2002,6(8):1136-1137. |
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| 作者姓名： | 李红旗 章翔 费舟 吴景文 贺晓生 白红民 |
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| 作者单位： | 解放军第四军医大学西京医院,陕西,西安,710032 |
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| 基金项目： | 军队重点学科基金资助项目(99-Z-146)，国家自然科学基金资助项目(39970266) |
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| 摘 要： | 目的探讨大鼠脑弥漫性轴索损伤(diffuseaxonalinjuries,DAI)后不同时期脑皮层组织中热休克蛋白(heatshockproteins,HSP)70的表达,为临床治疗脑损伤寻求有效手段。方法制作大鼠DAI模型,分别在伤后6、24、48、72h,7d以免疫组织化学方法检测大鼠脑皮层成纤维细胞生长因子(bFGF)的表达,分析其含量变化特点。结果DAI后24hHSP表达增加,48h达高峰,7d后仍维持较高水平。结论bFGF在各时间点表达有明显差异,提示其参与脑损伤后神经元保护及修复过程。
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| 关 键 词： | 弥漫性轴索损伤 热休克蛋白70 免疫组织化学 |
| 文章编号： | 1671-5926(2002)08-1136-02 |
| 修稿时间： | 2002年2月25日 |
Investigations on neuron protection and repairing effect of heat shock protein 70 after diffuse axis-cylinder injury of rats |
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| LI Hong qi,ZHANG Xiang,FEI Zhou,et al..Investigations on neuron protection and repairing effect of heat shock protein 70 after diffuse axis-cylinder injury of rats[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2002,6(8):1136-1137. |
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| Authors: | LI Hong qi ZHANG Xiang FEI Zhou |
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| Affiliation: | LI Hong qi,ZHANG Xiang,FEI Zhou,et al.Xijing Hospital,Fourth Military Medical University,Xi`an 710032,China |
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| Abstract: | Objective To study the expression and its roles of HSP in the cerebral contex of rats with diffuse axonal injuries in order to find a new method to treat brain injuries.Methods Diffuse axonal injuries were produced by DAI model. And the changes of bFGF expression in cerebral contex were detected by immunohistochemistry from 6 h to 7 d after injuries.Results The expression of HSP was increased at 24 h after DAI(P< 0.01).And its expression reached the highest level at 48h(P< 0.01),and still in a high level at 7d after injuries(P< 0.01).Conclusion Statistical analysis showed a significant difference in the expression of HSP after DAI in rats,which suggests that HSP plays an important role in the neuronal protection and repair after brain injuries. |
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| Keywords: | diffuse axonal injuries(DAI) heat shock proteins(HSP) immunohistochemistry |
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