新抗生素莫西沙星国内外研究应用最新进展

莫西沙星(moxifloxacin)属第四代氟喹诺酮类抗菌药物。莫西沙星通过抑制细菌的DNA螺旋酶A亚单位和拓扑异构酶IV的活性,阻断DNA的复制,从而发挥杀菌作用。对革兰阴性菌、阳性菌均有强大的抗菌能力,对支原体、衣原体、军团菌有效,对厌氧菌感染有效,尤其对某些临床常见的耐药菌有效。临床应用莫西沙星治疗社区获得性肺炎、急性细菌性鼻窦炎、泌尿生殖系感染、继发性腹膜炎、肺结核的早期及延长早期间治疗、强直性脊椎炎和皮肤、皮下组织感染的治疗。

Recent Progress on Application of a New Antibiotic Moxifloxacin

Moxifloxacin is one of the newly applied antibiotics fourth belonging to the forth generation of fluoroquinolone druds.This antibiotic can kill bacteria by inhibiting the activities of DNA helicase subunit A and topoismerase IV and blocking DNA reproduce copy.The moxifloxacin has a powerful ability against both the Gram-negative and Gram-positive bacteria including Mycoplasma,Chlamydia and Legionella.It has fine therapeutic effects to anaerobic infections and especially to some common drug resistant bacterial infections.In clinic,moxifloxacin was applied to treat community acquired pneumonia,acute bacterial sinusitis,urogenital system infections,secondary peritonitis,early and extended pulmonary tuberculosis,ankylosing spondylitis,skin and subcutaneous tissue infections.