| 超高效液相色谱-四极杆飞行时间质谱测定动物饲料中3种巴比妥类违禁药物 |
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| 引用本文： | 张峰,丁菲,储晓刚,李范珠,雍炜,王秀娟,吕泉福,许成保.超高效液相色谱-四极杆飞行时间质谱测定动物饲料中3种巴比妥类违禁药物[J].分析化学,2011,39(6):788-792. |
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| 作者姓名： | 张峰 丁菲 储晓刚 李范珠 雍炜 王秀娟 吕泉福 许成保 |
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| 作者单位： | 张峰,储晓刚,雍炜,王秀娟,ZHANG Feng,CHU Xiao-Gang,YONG Wei,WANG Xiu-Juan(中国检验检疫科学研究院,北京,100123);丁菲,DING Fei(中国检验检疫科学研究院,北京,100123;浙江中医药大学,杭州,310053);李范珠,LI Fan-Zhu(浙江中医药大学,杭州,310053);吕泉福,L(U) Quan-Fu(中国检验检疫科学研究院,北京,100123;西南大学,重庆,400715);许成保,XU Cheng-Bao(中国检验检疫科学研究院,北京,100123;河北农业大学,保定,071060) |
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| 基金项目： | 国家科技支撑计划，质检公益性行业科研项目，国家质检总局科技计划，北京市科技计划 |
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| 摘 要： | 建立了超高效液相色谱-四极杆飞行时间质谱(UPLC-O-TOF-MS)快速检测动物饲料中违禁添加的巴比妥、苯巴比妥和异戊巴比妥3种药物的分析方法.样品经甲醇振荡提取,再用C18固相萃取柱净化处理后,采用UPLC-O-TOF-MS分析检测.在电喷雾负离子模式和飞行时间模式下,以20mDa为提取离子窗口,输入各化合物的精确...
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| 关 键 词： | 液相色谱 四极杆-飞行时间质谱 饲料 巴比妥 |
Simultaneous Determination of Three Barbitals in Feeds by Ultra-Performance Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry |
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| ZHANG Feng,DING Fei,CHU Xiao-Gang,LI Fan-Zhu,YONG Wei,WANG Xiu-Juan,L Quan-Fu,XU Cheng-Bao.Simultaneous Determination of Three Barbitals in Feeds by Ultra-Performance Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry[J].Chinese Journal of Analytical Chemistry,2011,39(6):788-792. |
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| Authors: | ZHANG Feng DING Fei CHU Xiao-Gang LI Fan-Zhu YONG Wei WANG Xiu-Juan L Quan-Fu XU Cheng-Bao |
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| Affiliation: | ZHANG Feng,DING Fei,CHU Xiao-Gang,LI Fan-Zhu,YONG Wei,WANG Xiu-Juan,L(U) Quan-Fu,XU Cheng-Bao |
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| Abstract: | A method using ultra-performance liquid chromatography(UPLC) quadrupole-time-of-flight mass spectrometry(Q-TOF-MS) was developed for screening and confirmation of 3 barbital drugs,barbital,phenobarbital,amobarbital,in feeds.After homogenization,the samples were extracted with methanol,and then the extracts were directly purified through C18 cartridge.Identification and detection were achieved in the negative electrospray ionization(ESI) mode using Q-TOF-MS.Accurate mass measurements were performed at a mass... |
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| Keywords: | Ultra-performance liquid chromatography Quadrupole-time-of-flight mass spectrometry Feeds Barbital drugs |
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