| 杏仁肽对高脂血症大鼠辅助降血脂的功能研究 |
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| 引用本文： | 于兰兰,陈宇涵,刘 伟,周雅琳,李 雍,秦 勇,李睿珺,许雅君.杏仁肽对高脂血症大鼠辅助降血脂的功能研究[J].食品安全质量检测技术,2020,11(21):7849-7854. |
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| 作者姓名： | 于兰兰 陈宇涵 刘 伟 周雅琳 李 雍 秦 勇 李睿珺 许雅君 |
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| 作者单位： | 北京大学公共卫生学院营养与食品卫生学系,北京大学公共卫生学院营养与食品卫生学系,北京大学公共卫生学院营养与食品卫生学系,北京大学公共卫生学院营养与食品卫生学系,北京大学公共卫生学院营养与食品卫生学系,北京大学公共卫生学院营养与食品卫生学系,北京大学公共卫生学院营养与食品卫生学系,北京大学公共卫生学院营养与食品卫生学系;食品安全毒理学研究与评价北京市重点实验室 |
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| 基金项目： | 新疆维吾尔自治区重点研发计划项目(2017B03020-2) |
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| 摘 要： | 目的 探究杏仁肽对高脂血症模型大鼠是否具有辅助降血脂作用。方法 采用高脂饲料形成大鼠混合型高脂血症动物模型,将健康雄性40只SD大鼠随机分为5组,分别为空白对照组、高脂血症模型组和杏仁肽低、中、高剂量组(0.4、0.8和1.6 g/kg BW)。空白对照组每日给予维持饲料,其余各组每日给予高脂饲料。连续经口给予受试物30d,测定大鼠血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白(LDL-C)含量。结果 模型对照组和空白对照组比较,大鼠血清TG、TC及 LDL-C水平升高,差异均有统计学意义(P<0.05),判定混合型高脂血症动物模型成立。与模型对照组比较,杏仁肽低剂量组血清TC降低,差异具有统计学意义(P<0.05),同时杏仁肽各剂量组血清TG水平不显著高于模型对照组(P>0.05),杏仁肽各剂量组血清HDL-C水平不显著低于模型对照组(P>0.05)。结论 在一定剂量下,杏仁肽具有辅助降血脂功能。
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| 关 键 词： | 杏仁肽 高脂血症 血脂 |
| 收稿时间： | 2020/7/2 0:00:00 |
| 修稿时间： | 2020/10/17 0:00:00 |
Auxiliary hypolipidemic effect of almond peptides on rats with hyperlipidemia |
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| YU Lan-Lan,CHEN Yu-Han,LIU Wei,ZHOU Ya-Lin,LI Yong,QIN Yong,LI Rui-Jun,XU Ya-Jun.Auxiliary hypolipidemic effect of almond peptides on rats with hyperlipidemia[J].Food Safety and Quality Detection Technology,2020,11(21):7849-7854. |
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| Authors: | YU Lan-Lan CHEN Yu-Han LIU Wei ZHOU Ya-Lin LI Yong QIN Yong LI Rui-Jun XU Ya-Jun |
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| Affiliation: | Department of Nutrition and Food Hygiene, School of Public Health, Peking University,Department of Nutrition and Food Hygiene, School of Public Health, Peking University,Department of Nutrition and Food Hygiene, School of Public Health, Peking University,Department of Nutrition and Food Hygiene, School of Public Health, Peking University,Department of Nutrition and Food Hygiene, School of Public Health, Peking University,Department of Nutrition and Food Hygiene, School of Public Health, Peking University,Department of Nutrition and Food Hygiene, School of Public Health, Peking University,Department of Nutrition and Food Hygiene, School of Public Health, Peking University;Beijing Key Laboratory Toxicological Research and Risk Assessment for Food Safety, Peking University |
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| Abstract: | Objective To investigate the hypolipidemic effect of almond peptides on hyperlipidemia model of rats. Methods A high-fat diet was used to form a mixed animal model of hyperlipidemia in rats, and 40 healthy male SD rats were randomly divided into 5 groups, namely blank control group, hyperlipidemia model group and low dose, medium dose and high dose of almond peptides groups (0.4, 0.8 and 1.6 g/kg BW, respectively). The blank control group was given maintenance feed and the remaining groups were given high-fat diet daily. After the corresponding test substance was continuously administered orally for 30 days, the level of serum total serum cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein (LDL-C) were determined in rats. Results The serum TG, TC and LDL-C levels of the rats in the model control group significantly increased than the blank control group(P<0.05), suggesting the mixed hyper-lipidemia animal model was established. The serum TC level significantly decreased in the low-dose of al-mond peptides group than the model control, and the differences were statistically significant(P<0.05), and the serum TG level in each dose of almond peptides groups did not significantly decreased than the model con-trol group (P>0.05). The serum HDL-C level of in each dose of almond peptides groups did not significantly declined than the model control group (P>0.05). Conclusion At a certain dose, almond peptides have an aux-iliary effect of reducing blood lipid. |
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| Keywords: | almond peptides hypolipidemic blood lipid |
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