| 电离辐射与活性氧诱发人淋巴细胞姊妹染色单体交换与抑制细胞增殖率指数 |
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| 引用本文： | 罗黎明,郑荣梁,林念芸,金一尊.电离辐射与活性氧诱发人淋巴细胞姊妹染色单体交换与抑制细胞增殖率指数[J].辐射研究与辐射工艺学报,1995(2). |
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| 作者姓名： | 罗黎明 郑荣梁 林念芸 金一尊 |
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| 作者单位： | 兰州大学生物系，中国科学院辐射化学开放研究实验室，上海原子核所，上海医科大学放射医学研究所 |
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| 摘 要： | 电高辐射、超氧阴离子自由基和羟自由基都能分别引起人淋巴细胞姊妹染色单体交换（ＳＣＥ）频率增加和细胞增殖率指数降低。ＳＣＥ与增殖率指数间密切负相关。推测电离辐射的上述生物学效应正是由辐照细胞生成的超氧阴离子和羟自由基引起的。
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| 关 键 词： | 电离辐射，羟自由基，超氧阴离子自由基，姊妹染色单体交换，细胞增殖率指数 |
SISTER CHROMATID EXCHANGE AND INHIBITION OF CELL PROLIFERATION RATIO INDEX BY IONIZING IRRADIATION AND ACTIVE OXYGEN SPECIES |
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| Luo Liming, Zheng Rongliang.SISTER CHROMATID EXCHANGE AND INHIBITION OF CELL PROLIFERATION RATIO INDEX BY IONIZING IRRADIATION AND ACTIVE OXYGEN SPECIES[J].Journal of Radiation Research and Radiation Processing,1995(2). |
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| Authors: | Luo Liming Zheng Rongliang |
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| Abstract: | Sister chromatid exchange (SCE) and inhibition of cell proliferation ratio index (PRI) in human lympbocytes were induced by ionizing irradiation,superoxide anions and hydroxyl radical. There was a negative relationship betweenSCE and PRI. It was suggested that those biological effects were caused by superoxide anions and hydroxyl radicals produced in irradiated cells. |
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| Keywords: | Ionizing irradiation Hydroxyl radical Superoxide anion Sisterchromatid exchange Cell proliferation ratio index |
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