| 声化学激活血卟啉对瘤细胞K562作用的研究 |
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| 引用本文： | 宋存牛.声化学激活血卟啉对瘤细胞K562作用的研究[J].声学技术,2003,22(3):141-142,156. |
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| 作者姓名： | 宋存牛 |
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| 作者单位： | 长安大学基础课部,西安,710064 |
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| 摘 要： | 文章研究了超声激活血卟啉对人体肿瘤细胞K562的作用以及声辐照剂量和血卟啉浓度对瘤细胞杀伤率的影响。结果表明，声辐射剂量和血卟啉浓度和瘤细胞杀伤率呈正相关系。当频率为1．8MHz、声强度为1．5W／cm^2、作用时间为60s、血卟啉浓度为200μg／mL时，超声激活血卟啉对K562肿瘤作用效果较佳，杀伤率达98％，超声单独作用仅为42％，单纯血卟啉无抗肿瘤效应。
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| 关 键 词： | 血卟啉 肿瘤细胞K562 超声激活 抗肿瘤 杀伤率 声化学激活 |
| 文章编号： | 1000-3630(2003)03-0141-02 |
| 收稿时间： | 2002/2/28 0:00:00 |
| 修稿时间： | 2002/8/2 0:00:00 |
Effect of hematoporphyrin irradiated by ultrasound on tumor cell K562 |
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| SONG Cun-niu.Effect of hematoporphyrin irradiated by ultrasound on tumor cell K562[J].Technical Acoustics,2003,22(3):141-142,156. |
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| Authors: | SONG Cun-niu |
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| Abstract: | This paper studies the effect of hematoporphyrin(HP)irradiated by ultrasound on cell killing rate and the effect of both a-coustic parameter and HP concentration on cell killing rate. The results show that the cell-damaging rate rises with increasing HP concentration and acoustic dose. HP irradiated by ultrasound of 1. 8MHz at intensity 1. 5W/cm2 causes damage to 98% of the tumor cells in 60 seconds. However ultrasound alone only causes damage to 42% of the tumor cells, and HP alone has no anti-tumor effect. |
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| Keywords: | ultrasound hematoporphyrin anti tumor killing rate |
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