光敏剂在光动力治疗中的应用研究进展

光动力疗法（PDT）以其超高时空分辨率、非侵入性及低毒副作用的优点，被认为是治疗癌症和各种非恶性疾病的有效疗法之一。本文主要综述了几类光敏剂发展历史、主要结构、特点及研究进展，分析了高性能光敏剂的开发动态，包括化学修饰；与具有特定细胞受体的其他配体缀合成复合光敏剂；采取纳米技术，如纳米颗粒输送，基于富勒烯的光敏剂等。基于此，指出具有临床应用前景的高性能光敏剂的基本特征、设计原则及发展趋势。

Research Progress in Application of Photosensitizers in Photodynamic Therapy

Photodynamic therapy （PDT） is considered as an effective treatment of cancer and various non malignant diseases because of its advantages of super-high spatial-temporal resolution， non-invasive and low toxicity. In this paper， the development history， main structures， characteristics and research progress of several kinds of photosensitizers were reviewed. The developmental trends of high-performance photosensitizers were also analyzed， including chemical modification， compounding photosensitizers with other ligands that can be specifically received with cell， adopting nanotechnology such as nanoparticle transport， fullerene based photosensitizers， etc. Based on this， the basic characteristics， design principles and developmental trends of high-performance photosensitizers with clinical application values were pointed out.