多项指标联合检测在诊断及预防2型糖尿病早期肾损伤中的价值

目的探讨多项指标联合检测在诊断及预防2型糖尿病早期肾损伤中的价值。方法收集医院内分泌科150例2型糖尿病住院患者（包括高血糖组74例及低血糖组76例）,同时选取本院健康体检者75例,对其进行尿β2-微球蛋白（β2-MG）、尿微量清蛋白（mAlb）、尿素氮（BUN）、血清肌酐（SCr）、胱抑素C（Cys C）、超敏C-反应蛋白（hs-CRP）、糖化血红蛋白（HbA1c）的检测,并进行统计学分析。结果高血糖组β2-MG、mAlb、Cys C、hs-CRP、HbA1c分别为（2.45±0.80）mg/L、（30.23±10.05）mg/L、（1.35±0.53）mg/L、（8.45±4.03）mg/L、（14.05±3.35）%,明显高于低血糖组（P〈0.05）及健康对照组（P〈0.01）,差异均有统计学意义。结论 2型糖尿病患者应定期检测HbA1c、hs-CRP、Cys C及相关肾功能指标,有利于早期发现2型糖尿病并发的肾损害。

Diagnostic and preventive value of combined multiple indexes detection on early kidney injury in type 2 diabetes

Objective To discuss the diagnostic and preventive value of combined multiple indexes detection on early kidney injury in type 2 diabetes mellitus(T2DM).Methods 150 patients with T2DM were collected from our hospital,including 74 cases of hyperglycemia and 76 cases of hypoglycemia,then 75 individuals with healthy physical examination were as control group.The levels of β2-MG,mAlb,BUN,SCr,Cys C,hs-CRP,HbA1c were detected in the three groups and performed the statistical analysis on the results.Results The levels of β2-MG,mAlb,Cys C,hs-CRP,HbA1c in the hyperglycemia group were(2.45±0.80)mg/L,(30.23±10.05)mg/L,(1.35±0.53)mg/L,(8.45±4.03)mg/L and(14.05±3.35)%,which were obviously higher than those in the hypoglycemia group(P<0.05) and the healthy control group(P<0.01),with statistical differences.Conclusion Periodical detection of HbA1c,hs-CRP,CysC and the related indexes of renal function is beneficial to discover the early kidney injury in T2DM.