广西壮族自治区百色市高血压伴高尿酸血症患病率及其与超重血糖血脂血尿酸关系的研究

目的 探讨广西壮族自治区百色市高血压合并高尿酸血症(HUA)患病率及其与超重、血糖、血脂和血尿酸水平变化的关联性.方法 检测21 588名百色市居民身高、体质量、血压、血脂、血糖和血尿酸,进行探索性分析.采用方差分析、趋势x2检验、t检验以及Logistic回归等进行统计分析.结果 高血压患者6808例,患病率31.5％; HUA患者2592例,患病率12.0％；高血压伴HUA患者1260例,患病率5.8％.高血压伴HUA患者与血压、血尿酸正常者相比,其收缩压分别为(151±12)、(127±6) mm Hg]、舒张压分别为(84±10)、(72±6) mm Hg]、脉压分别为(50±12)、(37±8) mm Hg]、体质量指数(BMI)分别为(23.9±2.6)、(21.7±2.4) kg/m2],总胆固醇分别为(6.0±1.3)、(5.2±1.1) mmol/L],甘油三酯分别为(2.3±2.2)、(1.5±0.7) mmol/L],低密度脂蛋白胆固醇(LDL-C)分别为(3.4±1.3)、(3.0±1.1) mmol/L]均明显增高(P＜0.01),高密度脂蛋白胆固醇(HDL-C)分别为(1.2±0.4)、(1.5±0.5) mmol/L]明显降低(P＜0.01).高血压和HUA组患者,其舒张压、脉压、BMI、总胆固醇、甘油三酯和LDL-C均较健康组高(P＜0.01),HDL-C均值较健康组低(P＜0.01)；血压和血尿酸水平与BMI、血糖、总胆固醇、甘油三酯、HDL-C和LDL-C均有交互性(P＜0.01或P＜0.05)；血尿酸或血压水平增高者,其血压、肥胖和糖脂代谢观察指标的异常率高(P＜0.01),年龄、BMI、血糖、总胆固醇、甘油三酯和LDL-C都是高血压和HUA的独立危险因素；HUA者发生高血压的风险是血尿酸正常者的3.1倍,高血压患者HUA发病的风险是血压正常者的2.6倍.结论 百色市居民高血压和HUA患病率高,肥胖、糖脂代谢紊乱是高血压和HUA的共同病变基础,HUA与高血压可能存在着互为因果、相互作用的关系.

Study on the relevance between hypertension and serum uric acid in residents in Baise City of Guang-xi

Objective To realize the relevance between hypertension and serum uric acid (SUA) in residents in Baise City.Methods Twenty one thousand,five hundred and eighty eight Baise residents were examined.The body weight,height,waist circumference,hip circumference,blood pressure (BP) were recorded and blood lipidlevels,blood glucoseand serum uric acid (SUA) were tested.The relevance between hypertension and hyperuricemia (HUA) was analyzed by multi-factor variance analysis,x2 test,t test,linear regression and Logistic regression analysis.Results Hypertension prevalence rate was 31.5％,the frequency of HUA was 12.0％,and 5.8％ residents had both.For patients with both hypertension and HUA,when compared to those with normal serum uric level,their mean diastolic blood pressure (DBP) was (84±10),(72±6) mm Hg res-pectively,there mean systolic blood pressure (SBP) was (151±12),(127±6) mm Hg respectively,and pulse pressure (PP) was (50±12),(37±8) mm Hg respectively.The average BMI of those two groups was (23.9±2.6),(21.7±2.4) kg/m2 respectively.The average TC level was (6.0±1.3),(5.2±1.1)mmol/L respectively,the average TG level was (2.3±2.2),(1.5±0.7) mmol/L respectively,and the average LDL-C level was (3.4±1.3),(3.0±1.1) mmol/L respectively.All these parameters were higher than those people without hypertension or HUA (P＜0.01).However,the situation of HDL-C (1.2±0.4),(1.5±0.5)mmol/L] was the opposite (P＜0.01).Regression analysis had shown that age,BMI,waist-hip ratio,SUA,blood glucose,TC,TG,HDL-C and LDL-C were independent risk factors for hypertension,while people with HUA was 3.1 times more when compared to those without HUA.The prevalence rate of HUA in people with hypertension was 2.6 times higher than that of the control group.Conclusion Hypertension and HUA are two public health problems that prevalent in the residents in Baise City.Obesity,high blood glucose level and hyperlipidemia are thebasis for the development of hypertension and HUA.Hypertension can be the cause of HUA and verse versa.They may have mutual interactions.The adverse effect of HUA on-cardiovascular system should be taken into consideration clinically.