| 米托蒽醌聚乳酸缓释毫微粒针剂的制备 |
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| 引用本文： | 徐超群,廖工铁.米托蒽醌聚乳酸缓释毫微粒针剂的制备[J].中国医药工业杂志,1999,30(5):207-209. |
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| 作者姓名： | 徐超群 廖工铁 |
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| 作者单位： | 华西医科大学药学院 |
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| 摘 要： | 在单因素实验的基础上用均匀设计优化了米托蒽醌聚乳酸缓释微粒的制备方法。空白和载药微粒的平均粒径分别为１２９．９６和１３３．１５ｎｍ；包封率为９９．２３％；载药量为１３．５６％；制备收率为９９．３％。以乳和支架剂制得的冻干针剂外型美观、理化性质稳定，再分散后平均粒径为１５２．０２ｎｍ。用动态透析系统考察了不同分子量聚乳酸毫微粒冻干针剂的体外释药特性，结果显示高分子量聚乳酸微粒的释药速度明显慢于低分子
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| 关 键 词： | 米托蒽醌 缓释 聚乳酸 毫微粒 冻干针剂 制备 |
PREPARATION OF MITOXANTRONE POLYLACTIC ACID EXTENDED RELEASE NANOPARTICLE
LYOPHILIZATION INJECTION |
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| Authors: | XU Chao Qun LIAO Gong Tie ZHANG Zhi Rong |
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| Abstract: | The
preparation of DHAQ PLA NP colloidal solution was optimized by uniform design test on the
base of single factor experiment.The drug loading and embedding ratio were 13.56% and
99.23% respectively.The yield was 99.3%.The corresponding lyophilization injection was
prepared by using lactose as the supporting reagent.The lyophilization injection was stable in
chemical and physical properties.The average diameters of the nanoparticles in colloidal
solution and lyophilization injection were 133 nm and 155 nm respectively. |
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| Keywords: | mitoxantrone precipitate method polylactic acid embedding ratio and drug loading lyophilization injection |
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