四氢异喹啉衍生物的合成及抗真菌活性

目的 寻找新的抗真菌活性化合物。方法 采用Pictet-Spengler法合成四氢异喹啉，再通过氮直接烃化法合成目标化合物，并对目标化合物进行初步的体外抗真菌活性实验。结果 合成了18个新的四氢异喹啉衍生物，利用红外光谱、核磁共振谱进行了结构确认。结论 所合成的18个四氢异喹啉衍生物具有不同程度的抗真菌活性。

Syntheses and antifungal activities of the derivatives of tetrahydroisoquinoline

Aim To discover new active antifungal compounds. Methods Tetrahydroisoquinoline was synthesized through the Pictet-Spengler reaction,and the compounds were synthesized by way of alkylation.Preliminary antifungal activities were tested. Results The 18 compounds of 2-substituted-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline were synthesized and their structures were determined by IR and 1H-NMR and the antifungal activities in vitro were tested. Conclusion The results show that the compounds synthesized possess antifungal activities to a certain extent.