| 总状蕨藻盾叶变种多糖对小鼠T细胞亚群及NK细胞免疫功能的调节 |
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| 引用本文： | 庹菁菁,郭国庆,沈伟哉,黄日明.总状蕨藻盾叶变种多糖对小鼠T细胞亚群及NK细胞免疫功能的调节[J].暨南大学学报,2007,28(2):129-131. |
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| 作者姓名： | 庹菁菁 郭国庆 沈伟哉 黄日明 |
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| 作者单位： | 1. 暨南大学医学院人体解剖教研室,广东,广州,510632
2. 暨南大学生命科学技术学院化学系,广东,广州,510632 |
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| 基金项目： | 广东省自然科学基金
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广东省中医药管理局科研项目
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广东省广州市科技局资助项目 |
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| 摘 要： | 目的:观察总状蕨藻盾叶变种多糖对正常小鼠T细胞亚群及NK细胞的免疫调节作用.方法:腹腔注射总状蕨藻盾叶变种多糖溶液,用流式细胞仪检测血中免疫参数(CD3 ,CD4 ,CD8 T细胞亚群百分比)和脾脏NK细胞百分比,并测定胸腺、脾脏指数.结果:总状蕨藻盾叶变种多糖能明显降低小鼠血中CD3 ,CD4 ,CD8 百分比(P＜0.05),同时增强脾脏NK细胞百分比(P＜0.05),并显著降低胸腺指数(P＜0.05),增加脾脏指数(P＜0.05).结论:总状蕨藻盾叶变种多糖对小鼠T细胞亚群和NK细胞具有双向的免疫调节作用.
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| 关 键 词： | 总状蕨藻盾叶变种 多糖 T淋巴细胞亚群 NK细胞 免疫调节 总状蕨藻 多糖溶液 正常小鼠 细胞亚群 免疫功能 免疫调节作用 mice Natural killer cell T lymphocyte polysaccharides effect 胸腺指数 增强 结果 脾脏指数 测定 百分比 免疫参数 流式细胞仪检测 腹腔注射 |
| 文章编号： | 1000-9965(2007)02-0129-03 |
| 修稿时间： | 01 5 2006 12:00AM |
The immune modulatory effect of the Caulerpa racemosa var peltata polysaccharides on T lymphocyte subgroup and Natural killer cell in mice |
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| TUO Jing-jing,GUO Guo-qing,SHEN Wei-zai,HUANG Ri-ming.The immune modulatory effect of the Caulerpa racemosa var peltata polysaccharides on T lymphocyte subgroup and Natural killer cell in mice[J].Journal of Jinan University(Natural Science & Medicine Edition),2007,28(2):129-131. |
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| Authors: | TUO Jing-jing GUO Guo-qing SHEN Wei-zai HUANG Ri-ming |
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| Affiliation: | 1. Department of Anatomy, Medical College; 2. Department of Chemistry, Life Science and Technology College, Jinan University, Guangzhou 510632, China |
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| Abstract: | Aim:To investigate the immune modulatory effect of the Caulerpa racemosa var peltata poly-saccharides on T lymphocyte subgroup and NK cell in normal mice. Methods: The blood immunity parameter(CD+3,CD+4,CD+8 T lymphocyte subgroup percentage) and the NK cell percentage from spleen were detected with flow cytometry,the thymus index and spleen index were measured, after celiac injection of this alga polysaccharides liquor.Results: The significant differences from control group were found,the marked reduction in percentage of CD+3,CD+4,CD+8 in peripheral blood lymphocyte(P<0.05) was concomitant with the obvious increase in the percentage of NK cell in spleen lymphocyte(P<0.05).The results of immune apparatus weigh showed that the thymus index decreased(P<0.05) and the spleen index increased(P<0.05) noticeably.Conclusion:The data indicated that the Caulerpa racemosa var peltata polysaccharides may modulate the T lymphocyte subgroup and NK cell bilaterally in mice. |
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| Keywords: | Caulerpa racemosa var peltata polysaccharides T lymphocyte subgroup natural killer cell immune modulate |
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