| 正交试验法优选盐酸对氯苯肼的合成工艺 |
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| 引用本文： | 金戈,郑威,马珂.正交试验法优选盐酸对氯苯肼的合成工艺[J].华西药学杂志,2002,17(5):358-359. |
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| 作者姓名： | 金戈 郑威 马珂 |
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| 作者单位： | 浙江省人民医院药剂科,浙江,杭州,310014 |
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| 摘 要： | 目的：优选一种盐酸对氯苯肼合成工艺。方法：采用正交设计，以对氯苯肼合成工艺中滴加盐酸时的温度（A），滴加盐酸所用时间（B）还原反应温度（C）和还原反应时间（D）为4个因素，每因素选取3个水平进行试验，测定样品中杂质苯肼的含量。结果：因素A和 C对杂质苯肼的含量均有显著影响，因素B和D影响不显著。优化合成工艺为A2B1C3D1。结论：用正交试验法优选盐酸对氯苯肼合成工艺可行。
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| 关 键 词： | 正交试验 苯肼 对氯苯肼 合成 |
| 文章编号： | 1006-0103(2002)05-0358-02 |
| 修稿时间： | 2001年7月1日 |
OPTIMIZATION OF SYNTHETIC TECHNOLOGY OF p-CHLOROPHENYL-HYDRAZINE HYDROCHLORIDE BY ORTHOGONAL TEST |
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| JIN Ge,ZHENG Wei,MA Ke.OPTIMIZATION OF SYNTHETIC TECHNOLOGY OF p-CHLOROPHENYL-HYDRAZINE HYDROCHLORIDE BY ORTHOGONAL TEST[J].West China Journal of Pharmaceutical Sciences,2002,17(5):358-359. |
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| Authors: | JIN Ge ZHENG Wei MA Ke |
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| Affiliation: | JIN Ge,ZHENG Wei,MA Ke Department of Pharmaceutics,Zhejiang Prvincial People's Hospital,Hangzhou 310014,China |
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| Abstract: | OBJECTIVE To seek the optimal synthetic technology of p-chlorophenylhydrazine hydrochloride by orthogonal test.METHODS According to the L 9(3 4)orthogonal table,four factors were selected.The temperature and the extended time of hydrocholoride dropping were factor A and B, respectively. The temperature and the expended time of reductive reaction were the factor C and D,respectively.Three levels of each factor were chosen and the contents of phenylhydrazine were assessed.RESULTS The factor A and C had significant effect on the content of phenylhydrazine,and the optimeal synthetic technology was A 2B 1C 3D 1.CONCLUSION It was feasible to select the optimal synthetic technology of p-chlorophenylhydrazine hydrochloride by orthogonal test. |
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| Keywords: | Orthogonal test Phenylhydrazine p-Chlorophenylhydrazing hydrochloride Synthesis |
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