| 镰形棘豆提取物抗肿瘤活性的体外实验研究 |
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| 引用本文： | 张芳芳,杨光明,王 栋,王明艳,蔡宝昌.镰形棘豆提取物抗肿瘤活性的体外实验研究[J].药学与临床研究,2010,18(2):135-138. |
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| 作者姓名： | 张芳芳 杨光明 王 栋 王明艳 蔡宝昌 |
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| 作者单位： | 南京中医药大学,江苏省中药炮制重点实验室,国家中医药管理局中药炮制标准重点实验室,南京,210029 |
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| 基金项目： | 国家自然科学基金项目，江苏省中医药局项目 |
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| 摘 要： | 目的：对从镰形棘豆中分离得到的5种提取物进行体外抗肿瘤活性筛选。方法：采用四甲基偶氮唑盐（MTT）法观察镰形棘豆挥发油、总黄酮、总多糖、总生物碱及总皂苷对HepG2、MGC-803、LOVO、MCF-7、HeLa等5种人癌细胞株增殖的影响。结果：挥发油和总黄酮可以不同程度地抑制人癌细胞株的增殖。并呈现出一定的量效关系。结论：镰形棘豆的挥发油和总黄酮是抗肿瘤活性的主要部位．值得进一步深入地探讨和研究。
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| 关 键 词： | 镰形棘豆 癌细胞株 抗肿瘤 MTT法 |
| 收稿时间： | 2009/11/11 0:00:00 |
| 修稿时间： | 2009/12/24 0:00:00 |
Study on Anti-tumor Activity of Extracts of Oxytropis falcata in vitro |
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| ZHANG Fang-fang,YANG Guang-ming,WANG Dong,WANG Ming-yan and CAI Bao-chang.Study on Anti-tumor Activity of Extracts of Oxytropis falcata in vitro[J].Pharmacertical and Clinical Research,2010,18(2):135-138. |
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| Authors: | ZHANG Fang-fang YANG Guang-ming WANG Dong WANG Ming-yan and CAI Bao-chang |
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| Affiliation: | Nanjing University of TCM, Jiangsu Key Laboratory of Chinese Medicine Processing, State Key Laboratory of Standardization for Chinese Medicine Processing of State Administration of TCM of P.R.C., Nanjing 210029, China;Nanjing University of TCM, Jiangsu Key Laboratory of Chinese Medicine Processing, State Key Laboratory of Standardization for Chinese Medicine Processing of State Administration of TCM of P.R.C., Nanjing 210029, China;Nanjing University of TCM, Jiangsu Key Laboratory of Chinese Medicine Processing, State Key Laboratory of Standardization for Chinese Medicine Processing of State Administration of TCM of P.R.C., Nanjing 210029, China;Nanjing University of TCM, Jiangsu Key Laboratory of Chinese Medicine Processing, State Key Laboratory of Standardization for Chinese Medicine Processing of State Administration of TCM of P.R.C., Nanjing 210029, China;Nanjing University of TCM, Jiangsu Key Laboratory of Chinese Medicine Processing, State Key Laboratory of Standardization for Chinese Medicine Processing of State Administration of TCM of P.R.C., Nanjing 210029, China |
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| Abstract: | Objective: To investigate the cytotoxic activity of five extracts of Oxytropis falcata Bunge in vitro against HepG2, MGC-803, LOVO, MCF-7 and HeLa, so as to screen the main antitumor active extracts. Methods: Five extracts obtained from O |
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