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| 替莫唑胺多晶型的制备及其热稳定性 | |
| 引用本文： | 王海钠,庞华,董蓬,张君仁.替莫唑胺多晶型的制备及其热稳定性[J].中国医药工业杂志,2003,34(4):178-180. |
| 作者姓名： | 王海钠 庞华 董蓬 张君仁 |
| 作者单位： | 1. 山东大学药学院 2. 山东大学化学院 3. 山东省药品检验所,山东,济南,250012 |
| 摘 要： | 替莫唑胺在不同条件下进行了重结晶，经熔点、红外光谱、差热分析和粉末X—射线衍射法鉴定，确认替莫唑胺存在A、B两种晶型和一种粒状固体C，采用差热分析法对A、B和C的热稳定性进行了测定和比较。 |
| 关 键 词： | 替莫唑胺 热稳定性 X－射线衍射法 多晶型 制备 抗肿瘤药 |
| 文章编号： | 1001-8255(2003)04-0178-03 |
| 修稿时间： | 2002年9月10日 |
Preparation and Thermostability of Polymorphs of Temozolomide |
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| Authors: | WANG Hai-Na PANG Hua DONG Peng ZHANG Jun-Ren |
| Affiliation: | WANG Hai-Na1,PANG Hua2,DONG Peng3,ZHANG Jun-Ren 1 |
| Abstract: | The polymorphs A and B as well as a granular solid C of temozolomide were prepared by recrystallization from different solvents. Their characteristics were discussed by means of melting point, infrared spectrophotometry and X\|ray. In addition, the thermostability of A, B and C was studied by the differential scanning calorimetry. |
| Keywords: | temozolomide polymorph thermostability X-ray |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
