| 生物还原剂的作用机理研究概况 |
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| 引用本文： | 陈晓晶,金一尊.生物还原剂的作用机理研究概况[J].辐射研究与辐射工艺学报,2003,21(2):83-87. |
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| 作者姓名： | 陈晓晶 金一尊 |
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| 作者单位： | 复旦大学放射医学研究所,上海,200032 |
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| 基金项目： | 国家自然科学基金(30100042)资助 |
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| 摘 要： | 乏氧现象存在于多数实体肿瘤中。生物还原剂是一种具有肿瘤乏氧靶向性的前药，它会在还原性环境中被还原产生具有细胞毒性的代谢物。目前，生物还原剂主要有硝基杂环类、杂环氮氧类、醌类等几类。生物还原剂不仅可以作为放射增敏剂、化学增敏剂，还可以用于基因向导的酶前药治疗(GDEPT)。总之生物还原剂的研究对未来恶性肿瘤治疗有很大的意义。
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| 关 键 词： | 生物还原剂 作用机理 乏氧现象 基因向导酶前药治疗 恶性肿瘤 硝基杂环化合物 氮氧化合物 醌类化合物 |
| 修稿时间： | 2002年3月4日 |
A REVIEW ON THE STUDY OF BIOREDUCTIVE DRUGS |
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| CHEN Xiaojing,JIN Yizun.A REVIEW ON THE STUDY OF BIOREDUCTIVE DRUGS[J].Journal of Radiation Research and Radiation Processing,2003,21(2):83-87. |
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| Authors: | CHEN Xiaojing JIN Yizun |
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| Abstract: | Hypoxia is a feature that exists in most solid tumors. Bio-reductive drugs are pro-drugs that can selectively target the hypoxia cells in tumors. In reductive environment, they are reductively metabolized to generate toxic species. There are 3 main classes of bio-reductive drugs: the nitro-aromatics, N-oxides and quinones. Recently, bio-reductive drugs were combined with GDEPT for the treatment of cancer, in addition to radiation and the chemotherapeutic agents. Bio-reductive drugs will play a significant role in future cancer therapy. |
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| Keywords: | Bio-reductive drugs Hypoxia Reductive enzymes Gene-directed enzyme pro-drug therapy (GDEPT) Nitro-aromatics N-oxides Quinones |
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