姜黄素对高脂血症兔血液流变学、血小板聚集、抗氧化以及纤溶系统的影响

目的 观察姜黄素对高脂血症兔血液流变学、血小板聚集、抗氧化以及纤溶系统的影响。方法 新西兰兔摄取高脂饲料2周后,连续6周高脂饲料喂养并服用姜黄素。结果 各给药组兔的全血粘度、全血还原粘度、红细胞刚性指数和变型指数等指标有降低趋势,且随剂量的增加而增加(P<0.05, P<0.01),大剂量作用非常显著(P<0.01),对二磷酸腺苷(ADP)和胶原诱导的血小板聚集有一定的抑制作用,尤其大剂量组对胶原诱导的血小板聚集有明显的抑制作用(P<0.05),能使血清SOD水平显著提高,MDA和t-PA水平明显降低,对花生四稀酸诱导的血小板聚集未见明显影响。结论 姜黄素对高脂血症兔血液流变学可产生一定的有益作用,且具有抗氧化及促进纤溶的活性。

Effect of Curcumin on Hemorrheology, Platelet Aggregation, Anti-oxidation and Fibrinoly System of Hyperlipidemic Rabbit

OBJECTIVE To observe the effects of curcumin on hemorrheology, platelet aggregation, anti-oxidation and fibrinoly sestem of hyperlipidemic rabbits. METHODS Forty-eight rabbits randomly divided into 6 groups which including normal control, model, curcumin(10, 20, 40 mg·kg^-1) and Xuezhikang(32.5 mg·kg^-1) groups. After 8 weeks of high-fat food and 6 weeks of treatment of curcumin, blood rheology and oxygen free radical were measured in rabbits. RESULTS Blood reduction viscosity, red cell rigidity index and deformation index of the rabbit had the tendency of decrease. Curcumin also could inhibit the platelet aggregation, which induced by ADP and collagen. The levels of rabbit serum t-PA and MDA were lower, SOD was higher in curcumin group than that in hyperlipidemia group(P<0.01). CONCLUSION Curcumin can improve the hemorrheology of the hyperlipidemic rabbits. It possessed the ability of anti-oxidation and can improve the fibrinolsis system.