| 注射用复方维生素(4)的制备及质量考察 |
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| 引用本文： | 赵鹏,王东凯,邱志斌,张勖,陈婷,邓硕.注射用复方维生素(4)的制备及质量考察[J].中国新药杂志,2007,16(4):306-309. |
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| 作者姓名： | 赵鹏 王东凯 邱志斌 张勖 陈婷 邓硕 |
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| 作者单位： | 沈阳药科大学药学院,沈阳,110016 |
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| 摘 要： | 目的：制备注射用复方维生素（4）并考察其稳定性。方法：以含量、酸度为指标，筛选处方及制备工艺；并考察了3批样品的稳定性。结果：制剂最后处方为维生素A棕榈酸酯、维生素D2，维生素E，维生素K1加适宜的辅料制成，以该处方制备的3批样品在市售包装条件下经加速、室温留样试验考察，质量稳定。结论：处方设计合理，工艺可行。
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| 关 键 词： | 复方维生素 注射剂 制备 稳定性 |
| 文章编号： | 1003-3734（2007）04-0306-04 |
| 收稿时间： | 2006-06-08 |
| 修稿时间： | 2006-06-08 |
Preparation and quality control of vitamin compound for injection |
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| ZHAO Peng,WANG Dong-kai,QIU Zhi-bin,ZHANG Xu,CHEN Ting,DENG Shuo.Preparation and quality control of vitamin compound for injection[J].Chinese Journal of New Drugs,2007,16(4):306-309. |
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| Authors: | ZHAO Peng WANG Dong-kai QIU Zhi-bin ZHANG Xu CHEN Ting DENG Shuo |
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| Affiliation: | School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Objective:To study preparation and stability of vitamin compound for injection.Methods:The formula and preparation of vitamin compound for injection were optimized based on the contents and pH environment.Stabilities of 3 batches of the vitamin compound were investigated.Results:The optimal formula was consisted of Vitamin A palmitate,VitaminD2,Vitamin E,Vitamin K1 and appropriate excipients.The 3 batches of the samples in the commercial package were stable in the accelerated,room temperature storage tests.Conclusion:The optimal formula of vitamin compound for injection was achievable. |
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| Keywords: | vitamin compound injection preparation stability |
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