Feasibility study of large-scale mass customization 3D printing framework system with a case study on Nanjing Happy Valley East Gate

At present, the development and implementation of digital transformation are the keys to promoting high-quality industry development. The new digital fabrication method of robotic 3D printing is a research area being studied by many to tackle the issue of the declining productivity of traditional construction methods. Although many studies have been done, most of the current 3D printing projects are facing limitations in terms of scale. In order to bridge the gap, this article proposed a mass customization 3D printing framework system for large-scale projects. This article discusses how mass customization is made possible through the joint operation of the FUROBOT software and 3D printing hardware. By taking the east gate of Nanjing Happy Valley Plaza as a case study, the article demonstrates and studies the feasibility of the large-scale mass customization 3D printing framework system.     

Mass customization of medical devices and implants: state of the art and future directions

The medical field is one in which the need for customization can be clear cut, as providing tailored devices and implants for unique physiologies can provide for a better overall treatment than the use of 'off the shelf' devices and implants. Customization in the production of medical products can be roughly divided into consideration of medical devices, and of implantable parts or systems. The present paper outlines the current state of the art in both of these areas, presents details of projects that are ongoing at the University of Leeds and outlines future research directions.     

Interweaving genetic programming and genetic algorithm for structural and parametric optimization in adaptive platform product customization

An adaptive product platform offers high customizability for generating feasible product variants for customer requirements. Customization takes place not only to product platform structure but also to its relevant parameters. Structural and parametric optimization processes are interwoven with each other to achieve the total optimality. This paper presents an evolutionary method dealing with interwoven structural and parametric optimization of adaptive platform product customization. The method combines genetic programming and genetic algorithm for handling structural and parametric optimization, respectively. Efficient genetic representation and operation schemes are carefully adapted. While designing these schemes, features specific to structural and parameter customization are considered for the simplification of platform product management. The experimental results show that the performance of the proposed algorithm outperforms that of the tandem evolutionary algorithm in which a genetic algorithm for parametric optimization is totally nested in a genetic programming for structural optimization.     

提高定制产品物料需求预测的准确性

提高定制产品物料需求预测准确性是提高企业竞争能力的必由之路。通过某公司提高定制产品物料需求预测准确性的具体项目实践，介绍了关于提高物料需求预测准确性的具体措施。通过建立一种能为各部门所共同接受的产品语言来加强各部门的信息交流，并减少从客户的实际需求到物料预测之间的中间环节来提高整个物料预测的准确性，并以实例验证其有效性。     

面向大规模定制的虚拟设计研究

综述了大规模定制的范围经济性和面向大规模定制的基本设计方法，并提出了一个虚拟设计框架，该框架改变了传统的设计模式，利用先进的设计方法学和仿真支撑技术为产品开发提供了最大柔性和敏捷性。同时，它提供了一个多学科合作的设计环境，用户直接参与进设计循环中。最后，结合新型剑杆织机的开发，展示了一个能够支持新产品快速成功开发的虚拟设计环境。     

基于可拓学模型的大批量定制实施方法分析

简要阐述了当前企业环境的特点，分析了大批量定制及其可拓学模型；然后，从可拓学中的可拓工程出发，以“系列化”、“变型结构设计”和“变型工艺设计”为例，说明了可拓学在实施大批量定制中的应用，为企业寻找新的、有效的大批量定制实施方法提供料新的思路和工具。     

基于独立分量分析的图书馆个性化及时服务*

针对读者个性化服务质量的问题,提出了基于独立分量分析的图书馆个性化及时服务系统;简要给出了系统总体和个性化服务关键子系统的体系结构;重点讨论了利用独立分量分析方法改善系统个性化服务质量的问题.实验结果显示,利用此方法进行图书分类和读者群体聚类的效果较理想;读者群体和图书类别之间可产生随读者个性或图书主题变化而变化的动态映射关系,这种映射关系可以改善个性化服务质量.     

Nasal Epithelial Cell-Based Models for Individualized Study in Cystic Fibrosis

The emergence of highly effective CFTR modulator therapy has led to significant improvements in health care for most patients with cystic fibrosis (CF). For some, however, these therapies remain inaccessible due to the rarity of their individual CFTR variants, or due to a lack of biologic activity of the available therapies for certain variants. One proposed method of addressing this gap is the use of primary human cell-based models, which allow preclinical therapeutic testing and physiologic assessment of relevant tissue at the individual level. Nasal cells represent one such tissue source and have emerged as a powerful model for individual disease study. The ex vivo culture of nasal cells has evolved over time, and modern nasal cell models are beginning to be utilized to predict patient outcomes. This review will discuss both historical and current state-of-the art use of nasal cells for study in CF, with a particular focus on the use of such models to inform personalized patient care.     

面向网络化定制的产品族复合建模技术

在分析了网络化定制关键技术的基础上，针对性地对信息映射方法和产品族建进行了研究。提出了多层结构信息映射模型，以及综合类元件和参数化特征建模的双层复合产品族模型。结合本方法和以往网络化制造领域中所取得的成果，实现了较完整的基于Web的个性化定制过程。