DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in regulating gene expression. The epigenetic component is strongly involved in aging-bone diseases, such as osteoporosis and osteoarthritis. Both are complex multi-factorial late-onset disorders that represent a globally widespread health problem, highlighting a crucial point of investigations in many scientific studies. In recent years, new findings on the role of DNA methylation in the pathogenesis of aging-bone diseases have emerged. The aim of this systematic review is to update knowledge in the field of DNA methylation associated with osteoporosis and osteoarthritis, focusing on the specific tissues involved in both pathological conditions.     

生姜主要病虫害及其防治技术分析

生姜的根状茎为使用部分,其中包含姜油酮、姜油醇、姜油酚、蛋白质、粗脂肪、糖,并且钙、铁的含量也较为丰富,是人们日常生活当中不可或缺的调味品,还能够加工成为姜片、糖姜片和盐姜片等诸多食品,其在医药方面的应用也较为广泛,备受人们的推崇与喜爱。我国在生姜栽培方面的历史较为悠久,技术也较为成熟,每年生姜出口贸易都能为我国带来非常可观的经济效益。     

The Pathophysiological Role of CoA

The importance of coenzyme A (CoA) as a carrier of acyl residues in cell metabolism is well understood. Coenzyme A participates in more than 100 different catabolic and anabolic reactions, including those involved in the metabolism of lipids, carbohydrates, proteins, ethanol, bile acids, and xenobiotics. However, much less is known about the importance of the concentration of this cofactor in various cell compartments and the role of altered CoA concentration in various pathologies. Despite continuous research on these issues, the molecular mechanisms in the regulation of the intracellular level of CoA under pathological conditions are still not well understood. This review summarizes the current knowledge of (a) CoA subcellular concentrations; (b) the roles of CoA synthesis and degradation processes; and (c) protein modification by reversible CoA binding to proteins (CoAlation). Particular attention is paid to (a) the roles of changes in the level of CoA under pathological conditions, such as in neurodegenerative diseases, cancer, myopathies, and infectious diseases; and (b) the beneficial effect of CoA and pantethine (which like CoA is finally converted to Pan and cysteamine), used at pharmacological doses for the treatment of hyperlipidemia.     

基于电源、地桥的电源网络布线后优化

随着集成电路规模的不断增大,电源网络的重要性日趋显著,电源网络的分布直接影响芯片的电压降(IR-drop)。一种布线后通过在空闲处插入电源桥和地桥的方法,可以在不增加芯片面积的情况下,改善IR-drop效应。实验结果表明在芯片布局利用率不高的情况下(70~75%),该方法可以使IR-drop得到明显的优化。     

SCB火工品的研究与发展

文章评述了半导体桥火工品问世以来的研究成果与发展趋势。主要内容有半导体桥作用机理、半导体桥的结构与封装、半导体桥火工品的特点、半导体桥火工品的应用、半导体桥火工品的研究和发展趋势。     

300km/h高速铁路PC槽型梁动力试验研究

介绍北方交通大学与比利时鲁汶大学、布鲁塞尔自由大学、比利时铁路公司合作,在巴黎至布鲁塞尔之间高速铁路线上的Antoing大桥进行的二次高速铁路桥梁动力试验。试验桥梁由跨度50m的多跨预应力混凝土简支槽型梁构成,试验中列车速度达265-310km/h。通过现场试验和实验结果分析,得到了桥梁的频率、振型、阻尼等自振特性,以及桥梁在高速列车作用下的动挠度、梁和桥墩的横向和竖向加速度、橡胶支座的相对位移、梁体的动应变等动力响应特性。试验经验和测试结果对于充实高速铁路桥梁动力分析理论、改进数值分析模型、验证计算结果、提高高速铁路桥梁的动力设计水平、保证行车安全,具有重要的意义。     

ㄇ形梁剪力滞效应的解析解

精确分析ㄇ形梁在纵横向荷载共同作用下,其横断面上正应力分布规律对于计算其有效宽度有重要意义,应用力法原理,先将ㄇ形梁和翼板截开成矩形截面梁和平面应力板,在截面上代之以赘余的分布剪力,对于平面应力板,通过利用板变形的对称性来简化其边界条件,然后假设一个满足板的控制方程的Airy应力函数求得板的应力和位移,再利用Timoshenko梁理论求得梁的挠度和转角,根据截面上梁与板的纵向位移相等的变形协调条件便可最终确定截面上的分布剪力,给出的数值算例验证了方法的有效性,并与铜陵长江公路大桥主梁的模型有限元结果和试验结果作了对比,解析解法还可用来检验其他各种数值计算方法的精度,并可推广到其他多跨薄壁结构梁桥的膜应力分析中。     

交通平衡分配下的公路桥收费策略

假定一个城市被一条河流分为两部分（如我国的武汉，重庆等市），河上至少架设了两座公路桥梁，本文研究在交通平衡状态下，怎样制定车辆过桥梁的收费水平，使获得的总收入最大，乘客的总行驶时间最少，对多车种问题，研究了等价的数学模型和算法。还对一个含两座桥梁与三种车型的简单算例，进行了计算与分析。     

胃肠道激光内镜应用技术

本文结合作者的体验和文献，详细介绍了激光光导纤维检查与准备，激光内镜在胃肠道疾病应用的技巧、方法和注意事项等，可为临床医生和相关技术人员提供帮助。