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1.
Kevin Kyung Ho Choi Santosh Sanagapalli 《World journal of gastrointestinal oncology》2022,14(3):568-586
Barrett's esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC). Progression to cancer typically occurs in a stepwise fashion through worsening dysplasia and ultimately, invasive neoplasia. Established EAC with deep involvement of the esophageal wall and/or metastatic disease is invariably associated with poor long-term survival rates. This guides the rationale of surveillance of Barrett’s in an attempt to treat lesions at an earlier, and potentially curative stage. The last two decades have seen a paradigm shift in management of Barrett’s with rapid expansion in the role of endoscopic eradication therapy (EET) for management of dysplastic and early neoplastic BE, and there have been substantial changes to international consensus guidelines for management of early BE based on evolving evidence. This review aims to assist the physician in the therapeutic decision-making process with patients by comprehensive review and summary of literature surrounding natural history of Barrett’s by histological stage, and the effectiveness of interventions in attenuating the risk posed by its natural history. Key findings were as follows. Non-dysplastic Barrett’s is associated with extremely low risk of progression, and interventions cannot be justified. The annual risk of cancer progression in low grade dysplasia is between 1%-3%; EET can be offered though evidence for its benefit remains confined to highly select settings. High-grade dysplasia progresses to cancer in 5%-10% per year; EET is similarly effective to and less morbid than surgery and should be routinely performed for this indication. Risk of nodal metastases in intramucosal cancer is 2%-4%, which is comparable to operative mortality rate, so EET is usually preferred. Submucosal cancer is associated with nodal metastases in 14%-41% hence surgery remains standard of care, except for select situations. 相似文献
2.
Hajrunisa Cubro Karl A. Nath Sonja Suvakov Oscar Garcia-Valencia Santosh Parashuram Wendy M. White Tracey L. Weissgerber Meryl C. Nath Natasa M. Milic Fernando Sontag Livius V. d’Uscio Yi Zhu James L. Kirkland Tamar Tchkonia Mariam P. Alexander Reade A. Quinton Zvonimir S. Katusic Joseph P. Grande Vesna D. Garovic 《Kidney international》2021,99(3):646-656
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Hendrickx Gaelle De Roeck Veronique Russet Frdrick Dieleman Gwen Franic Tomislav Maras Athanasios McNicholas Fiona Paul Moli Santosh Paramala Schulze Ulrike Signorini Giulia Singh Swaran P. Street Cathy Tuomainen Helena Verhulst Frank Wolke Dieter Purper-Ouakil Diane Tremmery Sabine 《European child & adolescent psychiatry》2020,29(1):41-49
European Child & Adolescent Psychiatry - The majority of adolescents with mental health problems do not experience continuity of care when they reach the transition boundary of their child and... 相似文献
4.
Rodrguez-Quiroga A. Flamarique I. Castro-Fornieles J. Lievesley K. Buitelaar J. K. Coghill D. Daz-Caneja C. M. Dittmann R. W. Gupta A. Hoekstra P. J. Kehrmann L. Llorente C. Purper-Ouakil D. Schulze U. M. E. Zuddas A. Sala R. Singh J. Fiori F. Arango C. Santosh Paramala 《European child & adolescent psychiatry》2020,29(2):153-165
European Child & Adolescent Psychiatry - Suicidality in the child and adolescent population is a major public health concern. There is, however, a lack of developmentally sensitive valid and... 相似文献
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Subacute posttraumatic ascending myelopathy is a rare disorder, unrelated to syrinx formation or mechanical
instability, which may gradually emerge within the first 1-2 weeks after a spinal cord injury and may lead to diagnostic and prognostic dilemmas. We present a case of 24-year-old female with unstable wedge compression fracture of L1 vertebrae with signal changes in the upper lumbar cord causing complete paraplegia below D9 with bladder and bowel involvement. In the subsequent week, she developed a delayed progressively increasing neurological deficit with cord signal abnormality on MRI extending cephalad from the injury site to the upper dorsal cord. The patient had no initial clinical improvement initially but showed a delayed recovery over months. 相似文献
10.
A 41-year-old female patient presented with localized worsening subungual pain of her right index finger. Subsequent diagnostic evaluation revealed the presence of a glomus tumor. A glomus tumor is a rare tumor with a predilection for the hand. Classic symptoms include pain, pain with pressure, and pain with cold temperature. We present a completely updated literature review that addresses the epidemiology, pathology, presentation, diagnostic evaluation, classification, histology, genetics, and treatment options for glomus tumors. 相似文献