Effects of Electroacupuncture at Different Points on Colorectal Distention-induced Changes in Blood Pressure, Electrogastrogram, Gastric Tension and Gastric Blood Flow

Objective: To investigate the specificity of the effects of electroacupuncture (EA) at different acupoints on gastric functional activity and gastric blood flow after colorectal distension (CRD) in the rat. Methods: Fifty Wistar rats were randomly divided into 5 groups: a control group, a Zusanli group, a non-point group, a Taichong group and a Neiguan group. Rats were anesthetized after 18 h of fasting, and a rat model of nociceptive blood pressure elevation and abnormal electrogastrogram (EGG) and gastric tension (GT) was prepared by gasbag-induced CRD. EA was given bilaterally, and its effects on gastric blood flow (GBF) of the arcus vasculosi of the greater omentum, blood pressure, EGG fast wave properties, and gastric smooth muscle tension (GT) were quantified. Results: CRD induced an increase in blood pressure that was significantly inhibited by EA at all points (all P<0.05), and the inhibitory effects were greater in the Zusanli and Neiguan groups compared to the non-point group (both P<0.05). CRD also caused reductions in GT and GBF, and in the amplitude, frequency and duration of EGG waves (all P<0.05). These effects were also reversed by EA. The effects of EA on EGG wave amplitude, GT, and GBF were superior in the Zusanli group compared to the Taichong group, Neiguan group, and the non-point group. Conclusion: EA significantly counteracted CRD-induced changes in blood pressure, GBF, EGG, and GT. The effects of stimulation at Zusanli (ST 36) were significantly greater compared to other points, indicating relative specificity of this acupoint.     

家兔和大鼠在检测左心室内压时操作方法的差异

左心室内压(LVP)，左心室内压变化率(dp／dt)及左心室终末舒张压(LEDP)等是评价左心室功能的重要指标，这一指标的检测主要依赖于左心导管的插入。而大鼠、兔因对心血管药物反应敏感，且经济、易饲养、易获得，故在这类指标的相关研究中应用最多。在实际工作中发现，对这两种动物于颈动脉行左心导管插入术时，其难易程度并不完全取     

International Neuroscience Symposium for the 10^th Anniversary of the Hong Kong University of Science and Technology and the 4th Biennial Meeting of the Chinese Society for Neuroscience was held in Hong Kong

From 29th of September to 3rd of March of 2001, the International Neuroscience Symposium for the 10th Anniver-sary of tbe Hong Kong University of Science and Technology and tbe 4th Biennial Meeting of the Chinese Society forNeuroscience was held in Hong Kong. This meeting was organized mainly by Chinese Society for Neuroscience, NorthAmerican Medical Association of Hong Kong and tbe Department of Biology of Hong Kong University of Science andTechnique. More than 300 scholars atten…     

复发性口腔溃疡的中医药治疗进展

复发性口腔溃疡属于中医的"口疮"范畴。目前临床西医对该病的治疗尚无特效药物。中医认为该病可辨为心脾两经积热,脾虚清阳不升,阴虚火旺等证。中药在治疗复发性口腔溃疡方面有独特优势,有人偏重于清热解毒、滋阴降火,有人偏重于强调活血化瘀、益气养阴、补肾健脾等,只要辨证精准都可以取得肯定疗效。针灸、针药结合、穴位贴附、埋线疗法等中医特色治疗也是可行的选择。本文从复发性口腔溃疡的病因病机、中医药的内服外治法等方面进行浅析。     

新疆喀什地区健康教育与健康促进的难点与对策

新疆喀什地区是维吾尔族人口占98％以上的民族聚居地区，维吾尔族群众健康状况的好坏，直接关系到喀什地区总体健康教育水平的提高，并在相当程度上决定了喀什地区健康教育与健康促进的发展与未来。     

近10年来针灸学术的发展与思考

通过对近10年来针灸学术发展的梳理,实事求是地、客观地反映针灸学科在针灸基础、临床、器材、教学和标准化等方面的发展状况,展示针灸学术发展的科技进步成果和亮点,分析针灸学术发展进程中的瓶颈与困难.结果表明,目前针灸研究主要存在针灸理论研究规模小、投入少,基础研究与临床应用脱节,经穴-脏腑相关性有待系统深入研究,穴位主治作用的临床研究设计水平有待提高等问题.今后应遵循中医药传统理论和整体思维方法等固有规律,探索和发现针灸学术发展的新规律,以适应新的历史时期的需要,全面推进针灸学术事业可持续协调发展.     

脊髓小胶质细胞Toll样受体4和κ阿片受体的相互作用参与针刺镇痛的机制研究

目的:观察电针对慢性神经病理性疼痛大鼠脊髓小胶质细胞Toll样受体4(TLR4)和κ阿片受体(KOR)表达的影响,探讨脊髓小胶质细胞自身受体的相互作用参与电针镇痛的机制。方法:Wistar大鼠随机分为正常组、模型组、电针组和电针+抑制剂组,每组18只。结扎大鼠坐骨神经造成慢性压迫性损伤(CCI)疼痛模型。电针组、电针+抑制剂组于CCI术后第8天开始电针双侧"足三里""阳陵泉"(1 mA,2 Hz/15 Hz),30 min/次,1次/d,连续5 d;电针+抑制剂组于首次电针前给予大鼠腹腔注射KOR抑制剂JDTic(10 mg/kg)。用足底测痛仪测定大鼠双足对热刺激的缩足反应潜伏期(PWL);用免疫荧光法检测脊髓腰(L)2—L4段中小胶质细胞的形态和数量;用放射免疫法检测脊髓中强啡肽的含量;免疫磁珠法分离脊髓L2—L4段中的小胶质细胞后,用荧光定量PCR法检测脊髓和小胶质细胞中CD68和KOR mRNA的表达;用Western blot法检测小胶质细胞中TLR4蛋白的表达。结果:与正常组比较,模型组大鼠患健侧PWL差值(PWLD)明显增大(P<0.01),脊髓背角小胶质细胞标志物...     

针刺和蓖麻子油药针对大鼠流产和孕激素的影响

将毫针和蓖麻子油药针刺入大鼠涌泉穴观察对流产的影响,测定血浆黄体酮及雌二醇水平。结果:①针刺组和药针组的流产作用相似。②两组黄体酮水平均未见明显变化。③如果在第3,4,5天治疗,药针组动物血浆雌二醇显著降低;如果第15,16,17天治疗,两实验组的雌二醇水平均显著降低。针刺和蓖麻子油药针对大鼠流产和孕激素的影响@刘俊岭~~     

电针“内关”对心肌缺血所致兔胸髓背角神经元电活动反应的影响

在乌拉坦-氯醛糖麻醉兔上，用玻璃微电极细胞记录外背角神经元电活动，观察了胸髓（T2-T3）背角在整合电体“内关”和急性心肌缺血（AMI）信息中的作用。结果为：①AMI后，83个背角神经元中，18个放电频率明显增加，14个明显减少，其余51个没明显变化；②AMI引起兴奋反应的10个神经元中，电针“内关”后，有9个被抑制，1个仍呈兴奋状态；AMI引起抑制反应的8个神经元中，电针“内关”后有7个被解除抑制，另1个仍维持抑制状态；③检查了83个背角神经元的感受野及其反应的生理学类型。结果表明，电针“内关”与AMI的信息可在胸髓背角发生会聚性反应，背角参与电针“内关”与AMI的整合过程，因而亦是内关-心脏联系的环节之一。     

内关-心脏相关及孤束核的调控作用

经络学说是中医理论的重要内容,经络-脏腑相关是其核心。本文以心包经内关-心脏相关为主题,应用现代电生理学技术,外周与中枢相结合,在家兔急性心肌缺血模型上,证明电针“内关”可纠正缺血心肌电紊乱现象;双向调整急性心肌缺血所导致的孤束核、下丘脑后区基本活动过程的变化。提示这2个结构是内关-心脏相关联系的重要中枢环节。赋予经络-脏腑相关理论新的实验佐证,为临床针刺治疗缺血性心脏病提供了电生理学基础。