盐酸米托蒽醌与卡介苗膀胱灌注预防肿瘤复发的疗效

目的对比盐酸米托蒽醌与卡介苗膀胱灌注预防膀胱癌术后复发的效果。方法将100例膀胱癌经尿道电切除术后患者随机分成2组,一组患者膀胱灌注盐酸米托蒽醌,另一组膀胱灌注卡介苗,各组均灌注3～42个月,观察两组复发情况及不良反应。结果盐酸米托蒽醌组复发率为12%,不良反应率为8%,卡介苗组复发率为20%,不良反应率为64%;两组肿瘤复发率差异无统计学意义(P>0.05),但卡介苗不良反应发生率高于盐酸米托蒽醌(P<0.01)。结论盐酸米托蒽醌及卡介苗均能有效预防膀胱癌术后复发,但盐酸米托蒽醌膀胱灌注操作简单,不良反应小,是一种安全有效的膀胱局部化疗药物。     

动物源性再生型植入医疗器械社会合作网络分析：基于CNKI、万方、维普3大数据库中文文献研究

BACKGROUND: Tissue engineering involves many disciplines such as biology, material science, medicine and engineering, so, the collaboration among different research departments is becoming an important factor to enhancing research outputs with the rapid development of related sciences and technologies. OBJECTIVE: To draw the visualizing map of collaboration network of animal-derived regenerative implantable medical devices based on tissue engineering technology and describe its evolving process and current situation. METHODS: 2 518 Chinese literatures about the animal-derived regenerative implantable medical devices based on tissue engineering technology published before 31 December 2014 were searched in CNKI, WANFANG DATA and VIP. Subsequently, social network analysis was conducted on those literatures by utilizing UCINET software and SASI developed by Peking University. RESULTS AND CONCLUSION: The collaboration network of the animal-derived regenerative implantable medical devices has evolved from scattered to single-core dominated, and then to a core-edge one, characterized by increasing and extensive collaborations as well as decreasing network density and centralization. The core units from 2010 to 2014 include Tsinghua University, General Hospital of Chinese PLA and Affiliated Nanfang Hospital of South Medical University. Also, plenty of edge institutes exist. In conclusion, edge institutes should expand their scope of cooperation, while core institutes should improve their cooperation sustainability. Furthermore, cooperation among enterprises, research institutes and clinical hospitals should be strengthened to promote the industrialization of tissue engineering technology.     

京辽两地居民自由选择基本社会医保制度可行性分析调查报告

目的：通过对北京和辽宁两地居民基本社会医疗保险选择意愿的调查分析,对政府卫生支出进行估算,探索了经济发展水平不同地区建立城乡统筹的基本社会医疗保险的必要性和可行性。方法：运用2011年的实证调查数据,采用交叉列联表、线性回归、判别分析等统计方法,分析、对比了北京、辽宁居民对基本医疗保险的选择意愿及其人口学因素,估算了统筹城乡医保后两地政府卫生支出的变化。结果：按户籍和职业划分的医保只能满足部分居民的需求;户籍、受教育程度、上一年家庭医疗支出、年龄和是否有商业保险是影响两地居民医保种类选择的共性人口学变量;两地三类医保参加者均有提高报销比例的意愿,城镇职工和城镇居民希望降低起付线,新农合的起付线和缴费额度均存在提升空间;两地按居民期望达到北京市现有三大基本社会医疗保险的平均水平,且允许三大医保被居民自由选择时,北京市政府需多支出119．929亿元,辽宁省政府可节约36．214亿元。结论：在经济发展水平不同的京、辽两地将现行三种基本社会医疗保险制度转化为统一制度下的三种医保水平并允许居民自由选择,具有必要性和可行性。     

氟比洛芬酯用于无痛人工流产术疗效及安全性的临床研究

目的探讨氟比洛芬酯对无痛人工流产术麻醉及其术后镇痛的效果及安全性。方法 100例要求行人工流产者随机均分为2组。观察组先静脉注射氟比洛芬酯50 mg,10 min后静脉注射丙泊酚2 mg/kg;对照组先缓慢静脉注射芬太尼1μg/kg,10 min后静脉注射丙泊酚2 mg/kg。两组丙泊酚静注速率均为100 mg/min。记录两组用药前、睫毛反射消失时、术中、术毕时的SBP、HR、RR、SpO2,以及术毕清醒后1、5、15、30 min视觉模拟评分(VAS)值。记录手术时间、苏醒时间、丙泊酚总用药量、不良反应、术中麻醉效果。结果受术者睫毛反射消失时观察组SBP高于对照组(P<0.05);睫毛反射消失时及术中观察组RR、SpO2高于对照组(P<0.05),两组术中麻醉效果评定为优、良、差的例数及术毕清醒后1、5、15、30 min时下腹部疼痛VAS值比较,差异无统计学意义。结论在人工流产术中,氟比洛芬酯联合丙泊酚具有良好的术中麻醉及术后镇痛效果,对呼吸及循环抑制较轻,是一种较为安全有效的配伍方法。