INFLUENCE OF “SHUGANJIEYU” (舒肝解郁) HERBS ON CHOLERETIC FUNCTION IN ANESTHETIZED RATS

Experimental results of the choleretic ef-fect and influence on bile constituents of“Shuganjieyu (舒肝解郁)” herbs are reported.The evidence was that of the nine individuallytested herbs given 10 gm/kg via the duodenum,Lignum Aquilariae Resinatum,PericarpiumCitri Reticulatae Viride,Rhizoma Cyperi andPericarpium Citri Reticulatae markedly in-creased hepatic bile flow,for 3-4 hrs or longer.Radix Bupleuri,Fructus Aurantii and RadixCurcumae were also choleretic,though thesewere not so dramatically so.Compared withthe control,Fructus Aurantii and PericarpiumCitri Reticulatae Viride markedly and correspon-dingly elevated the cholic acid content and solidscomponent of bile.Bilirubin excretion increasedafter administration of Radix Aucklandiae.Two hrs after administering Fructus MeliaeToosendan the biliary lecithin level dropped toless than the control,though the drop was notstatistically significant.It is possible that“Shuganjieyu” exerts therapeutic action partlythrough choleresis,and that the so-calledGanyu (肝郁)symptoms mentioned in ancientChinese medical literature represent thepathologic processes of biliary excretion distur-bance.The pharmacological actions of “Shugan-jieyu” herbs as discussed may make the herbsbeneficial in enhancing liver function,prevent-ing cholesterol stone formation,diminishing in-trahepatic cholestatic jaundice risk,promotingabsorption of fat-soluble substances in the gut,and preventing steatorrhea.     

舒肝解郁药对麻醉大鼠泌胆功能的观察

舒肝解郁药(以下简称舒肝药)是用来解除肝郁病象的药物。祖国医学认为,肝有升发(疏)和透泄(泄)的功能,一旦肝失条达,疏泄失常,则引起肝气郁结,临床表现为胁肋胀痛、食欲不振,消化不良、胸闷不舒……等症状。本文以肝脏泌胆功能为观察指标,对临床常用的9种舒肝药进行观察,借此探讨中医解郁治疗的部分作用机理。